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Dock7
Gene Detail
 Symbol
Name
ID
Dock7
dedicator of cytokinesis 7
MGI:1914549
Synonyms 3110056M06Rik, LOC242555, m, mKIAA1771
Feature Type protein coding gene
Genetic Map
Chromosome 4
45.60 cM, cytoband C6
Detailed Genetic Map ± 1 cM


Mapping data(29)
Sequence Map
Chr4:98936675-99120860 bp, - strand
From VEGA annotation of GRCm38

  184186 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:23566  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Dock7

Human
homologs
Human Homolog DOCK7, dedicator of cytokinesis 7
NCBI Gene ID 85440
neXtProt AC  NX_Q96N67
Human Synonyms  EIEE23, ZIR2
Human Chr (Location)  1p31.3; chr1:62454726-62688368 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human DOCK7
Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Gene trapped(7) Spontaneous(2) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for mutations of this gene exhibit coat color dilution, white tail tip, and on some genetic backgrounds a white belly spot.
 
Human Diseases Modeled Using Mouse Dock7 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(1)
Interactions
Dock7 interacts with 214 markers (Mir15b, Mir18b, Mir22, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process activation of Rac GTPase activity, axonogenesis, ...
Component cell projection, COP9 signalosome
Function guanyl-nucleotide exchange factor activity, Rac GTPase binding
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (79)    Tissues (46)    Images (24)
Theiler Stages: 4, 9, 15, 17, 19, 23, 28
Assay TypeResults
RNA in situ 73
RT-PCR 6
cDNA source data(149)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(150) cDNA(149) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000008703 (Evidence)
Ensembl Gene ModelENSMUSG00000028556 (Evidence)
Entrez Gene67299 (Evidence)
UniGene260623
DFCITC1576852, TC1589063, TC1605446, TC1610428, TC1614650, TC1630135, TC1668761, TC1767741
NIA Mouse Gene IndexU025288
Consensus CDS ProjectCCDS38816.1, CCDS71425.1
International Mouse Knockout Project StatusDock7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008703 VEGA Gene Model | MGI Sequence Detail 184186 C57BL/6J ±  kb
transcript OTTMUST00000019759 VEGA | MGI Sequence Detail 7068 Not Applicable 
polypeptide OTTMUSP00000009053 VEGA | MGI Sequence Detail 2128 Not Applicable 

For the selected sequences
All sequences(103) RefSeq(25) UniProt(8)
Polymorphisms SNPs within 2kb(1273 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR026791 Dedicator of cytokinesis
InterPro IPR021816 Dedicator of cytokinesis C/D, N-terminal
InterPro IPR010703 Dedicator of cytokinesis C-terminal
InterPro IPR027007 DHR-1 domain
InterPro IPR027357 DHR-2 domain
Protein Ontology PR:000006624 dedicator of cytokinesis protein 7
References (Earliest) J:12159 Woolley GW, "Misty," a new coat color dilution in the mouse, Mus musculus. Am Naturalist. 1941;75:507-508
(Latest) J:208560 Neuhofer A, et al., Impaired local production of proresolving lipid mediators in obesity and 17-HDHA as a potential treatment for obesity-associated inflammation. Diabetes. 2013 Jun;62(6):1945-56
All references(104)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-12089, MGI:2685276, MGI:96903

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory