Dock7
Gene Detail

Symbol Name ID

Dock7 dedicator of cytokinesis 7 MGI:1914549

Synonyms

3110056M06Rik, LOC242555, m, mKIAA1771

Feature Type

protein coding gene

Genetic Map

Chromosome 4

45.60 cM, cytoband C6
Detailed Genetic Map ± 1 cM


Mapping data(29)

Sequence Map

Chr4:98936675-99120860 bp, - strand From VEGA annotation of GRCm38   184186 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:23566  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Dock7

Human homologs

Human Homolog		DOCK7, dedicator of cytokinesis 7
NCBI Gene ID		85440
neXtProt AC		NX_Q96N67
Human Synonyms		ZIR2
Human Chr (Location)		1p31.3; chr1:62920397-63153969 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(11) : Targeted(2) Gene trapped(7) Spontaneous(2)
 

Mice homozygous for mutations of this gene exhibit coat color dilution, white tail tip, and on some genetic backgrounds a white belly spot.

 
Human Diseases Modeled Using Mouse Dock7 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (17 annotations)

Process	activation of Rac GTPase activity, axonogenesis, ...
Component	cell projection, signalosome
Function	guanyl-nucleotide exchange factor activity, Rac GTPase binding

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (73)    Tissues (41)    Images (23)
Theiler Stages: 19, 23, 28

Assay Type	Results
RNA in situ	73

cDNA source data(146)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(146) cDNA(146)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000008703 (Evidence)
Ensembl Gene Model	ENSMUSG00000028556 (Evidence)
Entrez Gene	67299 (Evidence)
UniGene	260623
DFCI	TC1576852, TC1589063, TC1605446, TC1610428, TC1614650, TC1630135, TC1668761, TC1767741
NIA Mouse Gene Index	U025288
Consensus CDS Project	CCDS38816.1
International Mouse Knockout Project Status	Dock7

Sequences

Length	Strain/Species
genomic	OTTMUSG00000008703	VEGA Gene Model | MGI Sequence Detail	184186	C57BL/6J
transcript	OTTMUST00000019759	VEGA | MGI Sequence Detail	7068	Not Applicable
polypeptide	OTTMUSP00000009053	VEGA | MGI Sequence Detail	2128	Not Applicable

All sequences(80) RefSeq(2) UniProt(8)

Polymorphisms

SNPs(909 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR026791	Dedicator of cytokinesis
InterPro	IPR026798	Dedicator of cytokinesis C
InterPro	IPR027007	Dedicator of cytokinesis C2 domain
InterPro	IPR021816	Dedicator of cytokinesis C/D, N-terminal
InterPro	IPR010703	Dedicator of cytokinesis C-terminal
Protein Ontology	PR:000006624	dedicator of cytokinesis protein 7

References

(Earliest) J:12159 Woolley GW, "Misty," a new coat color dilution in the mouse, Mus musculus. Am Naturalist. 1941;75:507-508
(Latest) J:194766 Zhong X, et al., miR-21 is a key therapeutic target for renal injury in a mouse model of type 2 diabetes. Diabetologia. 2013 Mar;56(3):663-74
All references(94)

Other accession IDs

MGD-MRK-12089, MGI:2685276, MGI:96903