Slc25a19 MGI Mouse Gene Detail - MGI:1914533 - solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19

Slc25a19 Gene Detail

Symbol

Slc25a19
Name

solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19
Synonyms

2900089E13Rik, DNC, MUP1, TPC

Feature Type

protein coding gene
IDs

MGI:1914533
NCBI Gene: 67283
Gene Overview

MyGene.info: SLC25A19

Sequence Map

Chr11:115614178-115628281 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

14104 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 80.91 cM, cytoband E2
Mapping Data

2 experiments

Human Ortholog

SLC25A19, solute carrier family 25 member 19

Vertebrate Orthologs

10

Human Ortholog

SLC25A19, solute carrier family 25 member 19
Orthology source: HomoloGene, HGNC
Synonyms

DNC, MCPHA, MUP1, THMD3, THMD4, TPC
Links

HGNC:14409

NCBI Gene ID: 60386

neXtProt AC: NX_Q9HC21

UniProt: Q9HC21
Chr Location

17q25.1; chr17:75272980-75289957 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 5982
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: SLC25A19
Gene Tree

Slc25a19

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Phenotype Summary

15 phenotypes from 1 allele in 1 genetic background
2 images
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

49
Gene trapped

45
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

29 strains or lines available

Homozygous mutation of this gene results in lethality by E12, neural tube closure defects resulting in exencephaly and microcephaly, growth arrest, anemia, elevated alpha-ketoglutarate in amniotic fluid, and reduced thiamine pyrophosphate content in mitochondria.

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All GO Annotations

11
GO References

6

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

6
Tissues

5
cDNA Data

15
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase slc25a19

ZFIN slc25a19

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Slc25a19 interacts with 126 markers (Mir17, Mir19a, Mir19b-1, ...) View All

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All Sequences

79
RefSeq

16
UniProt

7
CCDS

CCDS25644.1, CCDS56819.1

			Length	Strain/Species	Flank
genomic	OTTMUSG00000003476	VEGA Gene Model \| MGI Sequence Detail	14104	C57BL/6J	± kb
transcript	OTTMUST00000007425	VEGA \| MGI Sequence Detail	2307	Not Applicable
polypeptide	OTTMUSP00000003574	VEGA \| MGI Sequence Detail	318	Not Applicable

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SNPs within 2kb

115 from dbSNP Build 142

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UniProt

7 Sequences
Protein Ontology

PR:000015014 mitochondrial thiamine pyrophosphate carrier

(term hierarchy)
InterPro Domains

IPR023395 Mitochondrial carrier domain

IPR002067 Mitochondrial carrier protein

IPR018108 Mitochondrial substrate/solute carrier

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All nucleic 17

cDNA 16

Primer pair 1

Microarray probesets 4

Summaries

All 38

Developmental Gene Expression 2

Gene Ontology 6

Phenotypes 8
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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