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Slc25a19
Gene Detail
Symbol

Name
ID
Slc25a19
solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19
MGI:1914533
Synonyms
2900089E13Rik, DNC, MUP1, TPC
Feature Type
protein coding gene
Genetic Map
Chromosome 11
80.91 cM, cytoband E2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:115614178-115628281 bp, - strand
From VEGA annotation of GRCm38

  14104 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:5982  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SLC25A19
Gene Tree: Slc25a19

Human
homologs
SLC25A19, solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 60386
neXtProt AC: NX_Q9HC21

Human Synonyms: DNC, MCPHA, MUP1, THMD3, THMD4, TPC

Human Chr (Location): 17q25.3; chr17:75272980-75289957 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human SLC25A19

Mutations,
alleles, and
phenotypes
All mutations/alleles(49) : Gene trapped(45) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in lethality by E12, neural tube closure defects resulting in exencephaly and microcephaly, growth arrest, anemia, elevated alpha-ketoglutarate in amniotic fluid, and reduced thiamine pyrophosphate content in mitochondria.
 
Human Diseases Modeled in Mice Using Slc25a19 (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(2)
Interactions
Slc25a19 interacts with 126 markers (Mir17, Mir19a, Mir19b-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process positive regulation of defense response to virus by host, transmembrane transport, ...
Component integral component of membrane, membrane, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (6)    Tissues (5)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 6
cDNA source data(15)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase slc25a19 ; ZFIN slc25a19    NEW 
Molecular
reagents
All nucleic(17) cDNA(16) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000003476 (Evidence)
Ensembl Gene Model ENSMUSG00000020744 (Evidence)
Entrez Gene 67283 (Evidence)
Consensus CDS Project CCDS25644.1, CCDS56819.1
International Mouse Phenotyping Consortium Status Slc25a19
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000003476 VEGA Gene Model | MGI Sequence Detail 14104 C57BL/6J ±  kb
transcript OTTMUST00000007425 VEGA | MGI Sequence Detail 2307 Not Applicable 
polypeptide OTTMUSP00000003574 VEGA | MGI Sequence Detail 318 Not Applicable 

For the selected sequences
All sequences(77) RefSeq(14) UniProt(7)
Polymorphisms
SNPs within 2kb(116 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023395 Mitochondrial carrier domain
InterPro IPR002067 Mitochondrial carrier protein
InterPro IPR018108 Mitochondrial substrate/solute carrier
Protein Ontology PR:000015014 mitochondrial thiamine pyrophosphate carrier
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(37)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory