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Med31 Gene Detail
Summary
  • Symbol
    Med31
  • Name
    mediator complex subunit 31
  • Synonyms
    3110004H13Rik, l11Jus15
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914529
    NCBI Gene: 67279
  • Gene Overview
    MyGene.info: MED31
Location & Maps
more
  • Sequence Map
    Chr11:72211724-72215592 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3869 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 43.93 cM, cytoband B4
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    MED31, mediator complex subunit 31
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MED31, mediator complex subunit 31
    Orthology source: HomoloGene, HGNC
  • Synonyms
    3110004H13Rik, CGI-125, Soh1
  • Links
    NCBI Gene ID: 51003
    neXtProt AC: NX_Q9Y3C7

  • Chr Location
    17p13.1; chr17:6643313-6651634 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 9368
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: MED31
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    19 phenotypes from 1 allele in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    1
  • Gene trapped
    4
  • Targeted
    1
  • Genomic Mutations
    2 involving Med31
  • Incidental Mutations
Mice homozygous for an ENU-induced allele exhibit developmental delay, reduced cell proliferation, reduced ossification and chondrogenesis, and death during late-gestation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006102 VEGA Gene Model | MGI Sequence Detail 3869 C57BL/6J ±  kb
transcript OTTMUST00000013789 VEGA | MGI Sequence Detail 1161 Not Applicable  
polypeptide OTTMUSP00000006390 VEGA | MGI Sequence Detail 131 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    75 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 51
    cDNA 50
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:2671283
References
more
  • Summaries
    All 32
    Developmental Gene Expression 3
    Gene Ontology 7
    Phenotypes 11
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:199738 Mauldin JP, et al., A link between the cytoplasmic engulfment protein Elmo1 and the Mediator complex subunit Med31. Curr Biol. 2013 Jan 21;23(2):162-7

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory