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Eri1 Gene Detail
Summary
  • Symbol
    Eri1
  • Name
    exoribonuclease 1
  • Synonyms
    3110010F15Rik, Eri1, Thex1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914526
    NCBI Gene: 67276
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:35932419-35962687 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 21.16 cM, cytoband B1.1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    823 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914526
 protein coding gene Chr8:35932407-35963350 (-)
129S1/SvImJ ENSMUSG00200007085
 protein coding gene Chr8:31026326-31049158 (-)
A/J ENSMUSG00195005749
 protein coding gene Chr8:31528394-31551229 (-)
AKR/J ENSMUSG00220005569
 protein coding gene Chr8:31291105-31313937 (-)
BALB/cJ ENSMUSG00180003100
 protein coding gene Chr8:31071765-31094598 (-)
C3H/HeJ ENSMUSG00175014442
 protein coding gene Chr8:31234327-31257159 (-)
C57BL/6NJ ENSMUSG00215006483
 protein coding gene Chr8:31001480-31032423 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030979
 protein coding gene Chr8:29687355-29709240 (-)
CAST/EiJ ENSTCUG00005005465
 protein coding gene Chr8:31192564-31223566 (-)
CBA/J ENSMUSG00210012733
 protein coding gene Chr8:31057294-31080127 (-)
DBA/2J ENSMUSG00185002124
 protein coding gene Chr8:36983562-37006394 (-)
FVB/NJ ENSMUSG00205002284
 protein coding gene Chr8:30269893-30292727 (-)
JF1/MsJ ENSUMUG00000007249
 protein coding gene Chr8:38677438-38708380 (-)
LP/J ENSMUSG00230009177
 protein coding gene Chr8:40631813-40656021 (-)
NOD/ShiLtJ ENSMUSG00190015322
 protein coding gene Chr8:31105202-31128034 (-)
NZO/HlLtJ ENSMUSG00225014387
 protein coding gene Chr8:44235592-44259822 (-)
PWK/PhJ ENSLUMG00010012359
 protein coding gene Chr8:30901028-30931963 (-)
SPRET/EiJ ENSMSPG00010004417
 protein coding gene Chr8:31633269-31656501 (-)
WSB/EiJ ENSIUOG00005005426
 protein coding gene Chr8:31866715-31887905 (-)



Homology
more
  • Human Ortholog
    ERI1, exoribonuclease 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ERI1, exoribonuclease 1
  • Synonyms
    3'HEXO, HEXO, HXAL, SEMDGC, SEMDGS, THEX1
  • Links
    NCBI Gene ID: 90459
    UniProt: Q8IV48

  • Chr Location
    8p23.1; chr8:9002147-9116746 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit postnatal lethality, decreased body size beginning at E15.5, and decreased proliferation of mouse embryonic fibroblasts.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    35
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    607
  • Tissues
    10
  • cDNA Data
    78
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 67276 NCBI Gene Model | MGI Sequence Detail 30269 C57BL/6J ±  kb
    transcript NM_026067 RefSeq | MGI Sequence Detail 5067 C57BL/6  
    polypeptide Q7TMF2 UniProt | EBI | MGI Sequence Detail 345 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 79
      cDNA 78
      Primer pair 1

      Microarray probesets 5
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 2
      Gene Ontology 10
      Phenotypes 10
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:360951 Guo L, et al., Null and missense mutations of ERI1 cause a recessive phenotypic dichotomy in humans. Am J Hum Genet. 2023 Jul 6;110(7):1068-1085
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory