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Eri1 Gene Detail
Summary
  • Symbol
    Eri1
  • Name
    exoribonuclease 1
  • Synonyms
    3110010F15Rik, Eri1, Thex1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914526
    NCBI Gene: 67276
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:35932419-35962687 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 8, 21.16 cM, cytoband B1.1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    322 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914526
protein coding gene Chr8:35932407-35963350 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033538
protein coding gene Chr8:34082335-34106460 (-)
A/J MGP_AJ_G0033518
protein coding gene Chr8:32711801-32735958 (-)
AKR/J MGP_AKRJ_G0033442
protein coding gene Chr8:33744991-33769116 (-)
BALB/cJ MGP_BALBcJ_G0033514
protein coding gene Chr8:32848560-32872685 (-)
C3H/HeJ MGP_C3HHeJ_G0033226
protein coding gene Chr8:34092900-34117996 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034030
protein coding gene Chr8:35354639-35378943 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030979
protein coding gene Chr8:29687355-29709240 (-)
CAST/EiJ MGP_CASTEiJ_G0032553
protein coding gene Chr8:33557192-33585225 (-)
CBA/J MGP_CBAJ_G0033204
protein coding gene Chr8:36747372-36771493 (-)
DBA/2J MGP_DBA2J_G0033357
protein coding gene Chr8:32669047-32693169 (-)
FVB/NJ MGP_FVBNJ_G0033302
protein coding gene Chr8:32330925-32355443 (-)
LP/J MGP_LPJ_G0033447
protein coding gene Chr8:34033962-34058086 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033344
protein coding gene Chr8:36182025-36206428 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034049
protein coding gene Chr8:33862782-33886924 (-)
PWK/PhJ MGP_PWKPhJ_G0032264
protein coding gene Chr8:32213525-32240292 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032095
protein coding gene Chr8:33122231-33146409 (-)
WSB/EiJ MGP_WSBEiJ_G0032669
protein coding gene Chr8:34043228-34067352 (-)



Homology
more
  • Human Ortholog
    ERI1, exoribonuclease 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ERI1, exoribonuclease 1
  • Synonyms
    3'HEXO, HEXO, HXAL, SEMDGC, SEMDGS, THEX1
  • Links
    NCBI Gene ID: 90459
    neXtProt AC: NX_Q8IV48
    UniProt: Q8IV48

  • Chr Location
    8p23.1; chr8:9002147-9116746 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit postnatal lethality, decreased body size beginning at E15.5, and decreased proliferation of mouse embryonic fibroblasts.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 67276 NCBI Gene Model | MGI Sequence Detail 30269 C57BL/6J ±  kb
    transcript NM_026067 RefSeq | MGI Sequence Detail 5067 C57BL/6  
    polypeptide Q7TMF2 UniProt | EBI | MGI Sequence Detail 345 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 79
      cDNA 78
      Primer pair 1

      Microarray probesets 5
    References
    more
    • Summaries
      All 35
      Developmental Gene Expression 2
      Gene Ontology 7
      Phenotypes 8
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:247390 Hoefig KP, et al., Eri1 degrades the stem-loop of oligouridylated histone mRNAs to induce replication-dependent decay. Nat Struct Mol Biol. 2013 Jan;20(1):73-81

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory