Vstm2b Gene Detail

Summary

• Symbol
  Vstm2b
• Name
  V-set and transmembrane domain containing 2B
• Synonyms
  2900093B09Rik

• Feature Type
  protein coding gene
• IDs
  MGI:1914525
  NCBI Gene: 58188
• Alliance
  gene page
• Transcription Start Sites
  6 TSS

Location &
Maps

• Sequence Map
  Chr7:40547334-40579468 bp, + strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 7, 27.88 cM, cytoband B2
• Mapping Data
  2 experiments

Strain
Comparison

• SNPs within 2kb
  444 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914525	protein coding gene	Chr7:40547334-40580018 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0032105	protein coding gene	Chr7:40548381-40581304 (+)
A/J	MGP_AJ_G0032085	protein coding gene	Chr7:39611794-39643967 (+)
AKR/J	MGP_AKRJ_G0032018	protein coding gene	Chr7:40786513-40818749 (+)
BALB/cJ	MGP_BALBcJ_G0032092	protein coding gene	Chr7:39861556-39896306 (+)
C3H/HeJ	MGP_C3HHeJ_G0031809	protein coding gene	Chr7:41397710-41431024 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0032570	protein coding gene	Chr7:42544586-42576837 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029603	protein coding gene	Chr7:40117749-40149450 (+)
CAST/EiJ	MGP_CASTEiJ_G0031144	protein coding gene	Chr7:32537940-32572398 (+)
CBA/J	MGP_CBAJ_G0031777	protein coding gene	Chr7:43878384-43911887 (+)
DBA/2J	MGP_DBA2J_G0031929	protein coding gene	Chr7:39530428-39564593 (+)
FVB/NJ	MGP_FVBNJ_G0031882	protein coding gene	Chr7:39267844-39300317 (+)
LP/J	MGP_LPJ_G0032008	protein coding gene	Chr7:40941288-40974466 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0031923	protein coding gene	Chr7:42655616-42689495 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0032584	protein coding gene	Chr7:40136561-40173024 (+)
PWK/PhJ	MGP_PWKPhJ_G0030866	protein coding gene	Chr7:32536293-32569612 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0030702	protein coding gene	Chr7:28855345-28888658 (+)
WSB/EiJ	MGP_WSBEiJ_G0031254	protein coding gene	Chr7:40579296-40611728 (+)

Homology

• Human Ortholog
  VSTM2B, V-set and transmembrane domain containing 2B

• Vertebrate Orthologs
  3

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  VSTM2B, V-set and transmembrane domain containing 2B
  
• Links
  HGNC:33595

  NCBI Gene ID: 342865

  neXtProt AC: NX_A6NLU5

  UniProt: A6NLU5

  
  
• Chr Location
  19q12; chr19:29525431-29564555 (+)  GRCh38.p7

---

• Alliance of Genome Resources
  Vstm2b stringent orthology
  1 human;1 mouse;1 rat;1 zebrafish
  
• HCOP
  vertebrate homology predictions: VSTM2B
• Gene Tree
  Vstm2b
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  1 phenotype reference
  

• All Mutations and Alleles
  2
• Targeted
  2
• Incidental Mutations
  Mutagenetix , APF , CvDC
• Find Mice (IMSR)
  10 strains or lines available

Gene Ontology
(GO)
Classifications

• All GO Annotations
  2
• GO References
  2

Expression

• Assay Results
  719
• Tissues
  8
• cDNA Data
  7
• Literature Summary
  2

Images

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase vstm2b

Interactions

• Vstm2b interacts with 100 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

Sequences &
Gene Models

• All Sequences
  51
• RefSeq
  16
• UniProt
  3
• CCDS
  CCDS21160.1

• Ensembl
  ENSMUSG00000039257 (Evidence)
• NCBI Gene
  58188

Representative Sequences			Length	Strain/Species
genomic	58188	NCBI Gene Model | MGI Sequence Detail	32135	C57BL/6J
transcript	NM_021387	RefSeq | MGI Sequence Detail	1455	C57BL/6
polypeptide	Q9JME9	UniProt | EBI | MGI Sequence Detail	285	Not Applicable

Protein
Information

• UniProt
  3 Sequences
• Protein Ontology
  PR:000032077 V-set and transmembrane domain-containing protein 2B
  (term hierarchy)
• InterPro Domains
  IPR007110 Immunoglobulin-like domain
  IPR036179 Immunoglobulin-like domain superfamily
  IPR013783 Immunoglobulin-like fold
  IPR003599 Immunoglobulin subtype
  IPR013106 Immunoglobulin V-set domain

Molecular
Reagents

• All nucleic 8

  cDNA 7

  Other 1

  
  

  Microarray probesets 3

Other
Accession IDs

MGI:1927557

References

• Summaries
  All 25

  Developmental Gene Expression 2

  Gene Ontology 2

  Phenotypes 1
• Earliest
  J:64911 Inoue S, et al., Growth suppression of Escherichia coli by induction of expression of mammalian genes with transmembrane or ATPase domains. Biochem Biophys Res Commun. 2000 Feb 16;268(2):553-61
• Latest
  J:229257 Gu Z, et al., Expression of the immunoglobulin superfamily cell adhesion molecules in the developing spinal cord and dorsal root ganglion. PLoS One. 2015;10(3):e0121550

TSS for Vstm2b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr65959	Chr7:40547608-40547637 (+)	289 bp
Tssr65960	Chr7:40548171-40548202 (+)	853 bp
Tssr65961	Chr7:40548207-40548243 (+)	891 bp
Tssr65962	Chr7:40548356-40548367 (+)	1,028 bp
Tssr65963	Chr7:40548371-40548384 (+)	1,044 bp
Tssr65964	Chr7:40552042-40552061 (+)	4,718 bp