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Myl12a Gene Detail
Summary
  • Symbol
    Myl12a
  • Name
    myosin, light chain 12A, regulatory, non-sarcomeric
  • Synonyms
    2900073G15Rik, brain specific myosin regulatory light chain, NMDA receptor-interacting protein
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914518
    NCBI Gene: 67268
  • Gene Overview
    MyGene.info: MYL12A
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:70993793-71002533 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 41.87 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    79 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914518
protein coding gene Chr17:70993656-71002878 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024003
protein coding gene Chr17:73418813-73432137 (-)
A/J MGP_AJ_G0023961
protein coding gene Chr17:71174674-71183810 (-)
AKR/J MGP_AKRJ_G0023930
protein coding gene Chr17:72157203-72169014 (-)
BALB/cJ MGP_BALBcJ_G0023962
protein coding gene Chr17:71101492-71110628 (-)
C3H/HeJ MGP_C3HHeJ_G0023726
protein coding gene Chr17:73118693-73128512 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024408
protein coding gene Chr17:76080207-76096811 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021853
protein coding gene Chr17:66956236-66965587 (-)
CAST/EiJ MGP_CASTEiJ_G0023207
protein coding gene Chr17:73532430-73547124 (-)
CBA/J MGP_CBAJ_G0023701
protein coding gene Chr17:79268787-79277923 (-)
DBA/2J MGP_DBA2J_G0023830
protein coding gene Chr17:69868028-69877163 (-)
FVB/NJ MGP_FVBNJ_G0023796
protein coding gene Chr17:69333825-69342961 (-)
LP/J MGP_LPJ_G0023912
protein coding gene Chr17:74174959-74185137 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023824
protein coding gene Chr17:79148201-79157337 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024452
protein coding gene Chr17:72675166-72686797 (-)
PWK/PhJ MGP_PWKPhJ_G0022953
protein coding gene Chr17:69164488-69173938 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022764
protein coding gene Chr17:69385314-69399533 (-)
WSB/EiJ MGP_WSBEiJ_G0023274
protein coding gene Chr17:73485662-73497252 (-)



Homology
more
  • Human Ortholog
    MYL12A, myosin light chain 12A
  • Vertebrate Orthologs
    11
  • Human Ortholog
    MYL12A, myosin light chain 12A
    Orthology source: HGNC
  • Synonyms
    HEL-S-24, MLC-2B, MLCB, MRCL3, MRLC3, MYL2B
  • Links
    NCBI Gene ID: 10627
    neXtProt AC: NX_O14950, NX_P19105
    UniProt: P19105

  • Chr Location
    18p11.31; chr18:3247482-3256237 (+)  GRCh38.p7

  • Human Ortholog
    MYL12B, myosin light chain 12B
    Orthology source: HomoloGene
  • Synonyms
    MLC-B, MRLC2
  • Links
    NCBI Gene ID: 103910
    neXtProt AC: NX_O14950
    UniProt: O14950

  • Chr Location
    18p11.31; chr18:3262113-3278284 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 67268 NCBI Gene Model | MGI Sequence Detail 8741 C57BL/6J ±  kb
transcript NM_026064 RefSeq | MGI Sequence Detail 1779 C57BL/6  
polypeptide NP_001344749 RefSeq | MGI Sequence Detail 178 C57BL/6  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 18
    cDNA 18

    Microarray probesets 5
Other
Accession IDs
less
MGI:2146927, MGI:2147135
References
more
  • Summaries
    All 30
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 5
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:213780 Garg A, et al., KLHL40 deficiency destabilizes thin filament proteins and promotes nemaline myopathy. J Clin Invest. 2014 Aug 1;124(8):3529-39

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory