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Zswim6 Gene Detail
Summary
  • Symbol
    Zswim6
  • Name
    zinc finger SWIM-type containing 6
  • Synonyms
    2900036G02Rik, mKIAA1577
Location & Maps
more
  • Sequence Map
    Chr13:107724617-107890064 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      165448 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 59.39 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    ZSWIM6, zinc finger SWIM-type containing 6
  • Vertebrate Orthologs
    8
  • Human Ortholog
    ZSWIM6, zinc finger SWIM-type containing 6
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AFND, NEDMAGA
  • Links
    NCBI Gene ID: 57688
    neXtProt AC: NX_Q9HCJ5
    UniProt: Q9HCJ5

  • Chr Location
    5q12.1; chr5:61332273-61546172 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human ZSWIM6 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit partial postnatal lethality, decreased striatal volume, abnormal medium spiny neuron morphology, and altered motor control including hyperactivity, impaired rotarod performance, repetitive movements, and behavioral hyperresponsiveness to amphetamine.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    • All Sequences
    • RefSeq
    • UniProt
    • UniGene
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 67263 NCBI Gene Model | MGI Sequence Detail 165448 C57BL/6J ±  kb
    transcript NM_145456 RefSeq | MGI Sequence Detail 5473 Not Specified  
    polypeptide Q80TB7 UniProt | EBI | MGI Sequence Detail 1207 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      976 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 35
      cDNA 34
      Other 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 32
      Developmental Gene Expression 4
      Gene Ontology 4
      Phenotypes 9
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:259070 Tischfield DJ, et al., Loss of the neurodevelopmental gene Zswim6 alters striatal morphology and motor regulation. Neurobiol Dis. 2017 Jul;103:174-183

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory