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Zfp422 Gene Detail
Summary
  • Symbol
    Zfp422
  • Name
    zinc finger protein 422
  • Synonyms
    2900028O21Rik, KOX15, Krox25, Krox-25-2, Krox26, Krox-26
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914505
    NCBI Gene: 67255
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:116600977-116605960 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 53.83 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    24 from dbSNP Build 142
  • Strain Annotations
    15
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914505
 protein coding gene Chr6:116600977-116605960 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031173
 protein coding gene Chr6:119309982-119315415 (-)
A/J MGP_AJ_G0031143
 protein coding gene Chr6:114740078-114745057 (-)
AKR/J MGP_AKRJ_G0031073
 protein coding gene Chr6:117820804-117824315 (-)
BALB/cJ MGP_BALBcJ_G0031153
 protein coding gene Chr6:114536439-114541614 (-)
C3H/HeJ no annotation
C57BL/6NJ no annotation
CAROLI/EiJ MGP_CAROLIEiJ_G0028776
 protein coding gene Chr6:111744744-111749897 (-)
CAST/EiJ MGP_CASTEiJ_G0030260
 protein coding gene Chr6:118205560-118211440 (-)
CBA/J MGP_CBAJ_G0023227
 protein coding gene Chr17:35826713-35828458 (-)
DBA/2J MGP_DBA2J_G0030993
 protein coding gene Chr6:113656486-113661030 (-)
FVB/NJ MGP_FVBNJ_G0030945
 protein coding gene Chr6:112830678-112837068 (-)
LP/J MGP_LPJ_G0031071
 protein coding gene Chr6:119337321-119345689 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030979
 protein coding gene Chr6:131341537-131348833 (-)
NZO/HlLtJ no annotation
PWK/PhJ MGP_PWKPhJ_G0029976
 protein coding gene Chr6:112670635-112677014 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029804
 protein coding gene Chr6:116597815-116601805 (-)
WSB/EiJ MGP_WSBEiJ_G0030343
 protein coding gene Chr6:118130388-118135344 (-)



Homology
more
  • Human Ortholog
    ZNF22, zinc finger protein 22
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZNF22, zinc finger protein 22
  • Synonyms
    HKR-T1, KOX15, Zfp422, ZNF422
  • Links
    NCBI Gene ID: 7570
    neXtProt AC: NX_P17026
    UniProt: P17026

  • Chr Location
    10q11.21; chr10:45000923-45005326 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 3 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for one null allele display increased grip strength. Mice with conditional loss in muscle cells display impaired muscle cell differentiation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1221
  • Tissues
    143
  • cDNA Data
    13
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 67255 NCBI Gene Model | MGI Sequence Detail 4984 C57BL/6J ±  kb
    transcript NM_001302440 RefSeq | MGI Sequence Detail 3411 C57BL/6  
    polypeptide Q9ERU3 UniProt | EBI | MGI Sequence Detail 237 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 13
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2146997
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 9
      Gene Ontology 8
      Phenotypes 8
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:297035 Nie Y, et al., Zfp422 promotes skeletal muscle differentiation by regulating EphA7 to induce appropriate myoblast apoptosis. Cell Death Differ. 2020 May;27(5):1644-1659
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory