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Peli1 Gene Detail
Summary
  • Symbol
    Peli1
  • Name
    pellino 1
  • Synonyms
    2810468L03Rik, A930031K15Rik, D11Ertd676e
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914495
    NCBI Gene: 67245
  • Gene Overview
    MyGene.info: PELI1
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:21091324-21150327 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 13.81 cM, cytoband A3.2
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    223 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914495
protein coding gene Chr11:21091291-21150327 (.)
129S1/SvImJ MGP_129S1SvImJ_G0018070
protein coding gene Chr11:18675161-18739471 (+)
A/J MGP_AJ_G0018043
protein coding gene Chr11:18012512-18072378 (+)
AKR/J MGP_AKRJ_G0018007
protein coding gene Chr11:18659985-18721380 (+)
BALB/cJ MGP_BALBcJ_G0018011
protein coding gene Chr11:18132554-18191374 (+)
C3H/HeJ MGP_C3HHeJ_G0017825
protein coding gene Chr11:18545018-18605326 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018463
protein coding gene Chr11:19518267-19580316 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016121
protein coding gene Chr11:16989830-17048625 (+)
CAST/EiJ MGP_CASTEiJ_G0017386
protein coding gene Chr11:18532115-18595750 (+)
CBA/J MGP_CBAJ_G0017799
protein coding gene Chr11:20355324-20420827 (+)
DBA/2J MGP_DBA2J_G0017909
protein coding gene Chr11:17963578-18023167 (+)
FVB/NJ MGP_FVBNJ_G0017901
protein coding gene Chr11:17727963-17786428 (+)
LP/J MGP_LPJ_G0017980
protein coding gene Chr11:18823736-18887522 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017927
protein coding gene Chr11:20770803-20834588 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018504
protein coding gene Chr11:18737501-18794884 (+)
PWK/PhJ MGP_PWKPhJ_G0017167
protein coding gene Chr11:17977380-18038226 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016964
protein coding gene Chr11:18466284-18522557 (+)
WSB/EiJ MGP_WSBEiJ_G0017440
protein coding gene Chr11:18389974-18451594 (+)



Homology
more
  • Human Ortholog
    PELI1, pellino E3 ubiquitin protein ligase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PELI1, pellino E3 ubiquitin protein ligase 1
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 57162
    neXtProt AC: NX_Q96FA3
    UniProt: Q96FA3

  • Chr Location
    2p14; chr2:64092652-64144471 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 23243
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: PELI1
  • Protein SuperFamily
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    33 phenotypes from 3 alleles in 3 genetic backgrounds
    1 images
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit reduced proinflammatory cytokine production, B cell proliferation, and mortality following treatment with LPS or pIpC.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 67245 NCBI Gene Model | MGI Sequence Detail 59004 C57BL/6J ±  kb
    transcript NM_023324 RefSeq | MGI Sequence Detail 3501 C57BL/6  
    polypeptide Q8C669 UniProt | EBI | MGI Sequence Detail 418 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 106
      cDNA 103
      Primer pair 2
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1277131, MGI:1925214, MGI:2144003, MGI:2144230
    References
    more
    • Summaries
      All 65
      Developmental Gene Expression 5
      Gene Ontology 7
      Phenotypes 21
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:263339 Choi SW, et al., PELI1 Selectively Targets Kinase-Active RIP3 for Ubiquitylation-Dependent Proteasomal Degradation. Mol Cell. 2018 Jun 7;70(5):920-935.e7

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory