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Smc6 Gene Detail
Summary
  • Symbol
    Smc6
  • Name
    structural maintenance of chromosomes 6
  • Synonyms
    2810489L22Rik, 3830418C19Rik, Smc6l1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914491
    NCBI Gene: 67241
  • Gene Overview
    MyGene.info: SMC6
Location & Maps
more
  • Sequence Map
    Chr12:11265886-11319785 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      53900 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 5.58 cM, cytoband A2
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    SMC6, structural maintenance of chromosomes 6
  • Vertebrate Orthologs
    11
  • Human Ortholog
    SMC6, structural maintenance of chromosomes 6
    Orthology source: HomoloGene, HGNC
  • Synonyms
    hSMC6, SMC-6, SMC6L1
  • Links
    NCBI Gene ID: 79677
    neXtProt AC: NX_Q96SB8

  • Chr Location
    2p24.2; chr2:17663812-17753829 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    21 phenotypes from 3 alleles in 2 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    15
  • Gene trapped
    10
  • Targeted
    5
  • Incidental Mutations
Mice homozygous for a gene trap allele exhibit poor embryonic development and embryonic lethality by E105. Mice homozygous for a hypomorphic allele exhibit decreased body weight and weight, decreased litter size and partial lethality. Mice homozygous for a point mutation exhibit a milder phenotype.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 67241 NCBI Gene Model | MGI Sequence Detail 53900 C57BL/6J ±  kb
transcript NM_025695 RefSeq | MGI Sequence Detail 5603 C57BL/6  
polypeptide Q924W5 UniProt | EBI | MGI Sequence Detail 1097 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    264 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000015275 structural maintenance of chromosomes protein 6
  • InterPro Domains
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR003395 RecF/RecN/SMC, N-terminal
    IPR033268 Structural maintenance of chromosomes protein 5/6
    IPR027132 Structural maintenance of chromosomes protein 6
Molecular
Reagents
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  • All nucleic 24
    cDNA 24

    Microarray probesets 8
Other
Accession IDs
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MGI:1913919, MGI:2144945, MGI:2145054
References
more
  • Summaries
    All 36
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 9
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:220422 Ju L, et al., SMC6 is an essential gene in mice, but a hypomorphic mutant in the ATPase domain has a mild phenotype with a range of subtle abnormalities. DNA Repair (Amst). 2013 May 1;12(5):356-66

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory