About   Help   FAQ
Nprl2 Gene Detail
Summary
  • Symbol
    Nprl2
  • Name
    NPR2 like, GATOR1 complex subunit
  • Synonyms
    2810446G01Rik, G21, NPR2L, NPRL2, Tusc4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914482
    NCBI Gene: 56032
  • Gene Overview
    MyGene.info: NPRL2
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:107542226-107545706 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 58.12 cM, cytoband F1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    52 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914482
protein coding gene Chr9:107542206-107545706 (.)
129S1/SvImJ MGP_129S1SvImJ_G0035255
protein coding gene Chr9:109417727-109421206 (+)
A/J MGP_AJ_G0035234
protein coding gene Chr9:105439222-105442701 (+)
AKR/J MGP_AKRJ_G0035166
protein coding gene Chr9:108071352-108074831 (+)
BALB/cJ MGP_BALBcJ_G0035228
protein coding gene Chr9:105108489-105111968 (+)
C3H/HeJ MGP_C3HHeJ_G0034938
protein coding gene Chr9:108470512-108473991 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035748
protein coding gene Chr9:112409223-112412703 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032646
protein coding gene Chr9:102868016-102871654 (+)
CAST/EiJ MGP_CASTEiJ_G0034249
protein coding gene Chr9:108403151-108406636 (+)
CBA/J MGP_CBAJ_G0034906
protein coding gene Chr9:116382284-116385764 (+)
DBA/2J MGP_DBA2J_G0035067
protein coding gene Chr9:104892899-104896379 (+)
FVB/NJ MGP_FVBNJ_G0035015
protein coding gene Chr9:103657770-103661249 (+)
LP/J MGP_LPJ_G0035143
protein coding gene Chr9:109623837-109627357 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035054
protein coding gene Chr9:117995368-117998847 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035769
protein coding gene Chr9:108342816-108346295 (+)
PWK/PhJ MGP_PWKPhJ_G0033956
protein coding gene Chr9:105212298-105216303 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033791
protein coding gene Chr9:108398852-108402324 (+)
WSB/EiJ MGP_WSBEiJ_G0034370
protein coding gene Chr9:108225952-108229431 (+)



Homology
more
  • Human Ortholog
    NPRL2, NPR2 like, GATOR1 complex subunit
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NPRL2, NPR2 like, GATOR1 complex subunit
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FFEVF2, NPR2, NPR2L, TUSC4
  • Links
    NCBI Gene ID: 10641
    neXtProt AC: NX_Q8WTW4
    UniProt: Q8WTW4

  • Chr Location
    3p21.31; chr3:50347487-50351055 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 4771
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: NPRL2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit reduced embryo size, microphthalmia, occaional anophthalmia, pale liver, reduced fetal liver hematopoiesis, impaired erythropoiesis and reduced methionine synthesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000010057 Ensembl Gene Model | MGI Sequence Detail 3481 C57BL/6J ±  kb
transcript ENSMUST00000010201 Ensembl | MGI Sequence Detail 1441 Not Applicable  
polypeptide ENSMUSP00000010201 Ensembl | MGI Sequence Detail 380 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 62
    cDNA 62

    Microarray probesets 3
References
more
  • Summaries
    All 31
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 6
  • Earliest
    J:66052 Lerman MI, et al., The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium [In Process Citation]. Cancer Res. 2000 Nov 1;60(21):6116-33
  • Latest
    J:224837 Dutchak PA, et al., Regulation of Hematopoiesis and Methionine Homeostasis by mTORC1 Inhibitor NPRL2. Cell Rep. 2015 Jul 21;12(3):371-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/13/2018
MGI 6.13
The Jackson Laboratory