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Nprl2 Gene Detail
Summary
  • Symbol
    Nprl2
  • Name
    nitrogen permease regulator-like 2
  • Synonyms
    2810446G01Rik, G21, NPR2L, NPRL2, Tusc4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914482
    NCBI Gene: 56032
  • Gene Overview
    MyGene.info: NPRL2
Location & Maps
more
  • Sequence Map
    Chr9:107542226-107545706 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3481 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 58.12 cM, cytoband F1
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    NPRL2, NPR2-like, GATOR1 complex subunit
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NPRL2, NPR2-like, GATOR1 complex subunit
    Orthology source: HGNC, HomoloGene
  • Synonyms
    NPR2, NPR2L, TUSC4
  • Links
    NCBI Gene ID: 10641
    neXtProt AC: NX_Q8WTW4

  • Chr Location
    3p21.3; chr3:50347487-50351055 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 4771
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: NPRL2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotype references
  • All Mutations and Alleles
    3
  • Gene trapped
    1
  • Targeted
    2
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000050748 VEGA Gene Model | MGI Sequence Detail 3481 C57BL/6J ±  kb
transcript OTTMUST00000128609 VEGA | MGI Sequence Detail 1441 Not Applicable  
polypeptide OTTMUSP00000069163 VEGA | MGI Sequence Detail 380 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    52 from dbSNP Build 142
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000016841 tumor suppressor candidate 4
  • InterPro Domains
    IPR009348 Nitrogen permease regulator 2
Molecular
Reagents
less
  • All nucleic 61
    cDNA 61

    Microarray probesets 3
References
more
  • Summaries
    All 28
    Developmental Gene Expression 1
    Gene Ontology 1
    Phenotypes 5
  • Earliest
    J:66052 Lerman MI, et al., The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium [In Process Citation]. Cancer Res. 2000 Nov 1;60(21):6116-33
  • Latest
    J:224837 Dutchak PA, et al., Regulation of Hematopoiesis and Methionine Homeostasis by mTORC1 Inhibitor NPRL2. Cell Rep. 2015 Jul 21;12(3):371-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory