Prpf18 MGI Mouse Gene Detail - MGI:1914479 - pre-mRNA processing factor 18

Symbol

Prpf18
Name

pre-mRNA processing factor 18
Synonyms

2810441A10Rik

Feature Type

protein coding gene
IDs

MGI:1914479
NCBI Gene: 67229
Alliance

genome feature page
Transcription Start Sites

2 TSS

Sequence Map

Chr2:4626869-4656924 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 2.79 cM, cytoband A1
Mapping Data

2 experiments

SNPs within 2kb

888 from dbSNP Build 142
Strain Annotations

29

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914479	protein coding gene	Chr2:4626869-4656946 (-)
129S1/SvImJ	ENSMUSG00200030985	protein coding gene	Chr2:1483552-1512923 (-)
A/J	ENSMUSG00195015325	protein coding gene	Chr2:1602306-1603782 (-)
A/J	ENSMUSG00195015307	protein coding gene	Chr2:1603262-1632335 (-)
AKR/J	ENSMUSG00220005583	protein coding gene	Chr2:1593851-1595327 (-)
AKR/J	ENSMUSG00220005577	protein coding gene	Chr2:1594807-1623878 (-)
BALB/cJ	ENSMUSG00180029158	protein coding gene	Chr2:1696600-1725672 (-)
BALB/cJ	ENSMUSG00180029192	protein coding gene	Chr2:1695644-1697120 (-)
C3H/HeJ	ENSMUSG00175015514	protein coding gene	Chr2:1592313-1593789 (-)
C3H/HeJ	ENSMUSG00175015496	protein coding gene	Chr2:1593269-1622338 (-)
C57BL/6NJ	ENSMUSG00215012207	protein coding gene	Chr2:1717916-1746989 (-)
C57BL/6NJ	ENSMUSG00215012276	protein coding gene	Chr2:1716960-1718436 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023143	protein coding gene	Chr2:1455820-1487901 (-)
CAST/EiJ	ENSTCUG00005004783	protein coding gene	Chr2:1560717-1592093 (-)
CBA/J	ENSMUSG00210027262	protein coding gene	Chr2:1632600-1634076 (-)
CBA/J	ENSMUSG00210027245	protein coding gene	Chr2:1633556-1662631 (-)
DBA/2J	ENSMUSG00185011731	protein coding gene	Chr2:1592083-1593559 (-)
DBA/2J	ENSMUSG00185011723	protein coding gene	Chr2:1593039-1622110 (-)
FVB/NJ	ENSMUSG00205024911	protein coding gene	Chr2:1579445-1580921 (-)
FVB/NJ	ENSMUSG00205024729	protein coding gene	Chr2:1580401-1609473 (-)
JF1/MsJ	ENSUMUG00000001281	protein coding gene	Chr2:1563700-1593411 (-)
LP/J	ENSMUSG00230002392	protein coding gene	Chr2:3531576-3560947 (-)
NOD/ShiLtJ	ENSMUSG00190005522	protein coding gene	Chr2:1594240-1595716 (-)
NOD/ShiLtJ	ENSMUSG00190005517	protein coding gene	Chr2:1595196-1624274 (-)
NZO/HlLtJ	ENSMUSG00225001459	protein coding gene	Chr2:11269421-11298493 (-)
NZO/HlLtJ	ENSMUSG00225001463	protein coding gene	Chr2:11268465-11269941 (-)
PWK/PhJ	ENSLUMG00010026709	protein coding gene	Chr2:1611148-1642238 (-)
SPRET/EiJ	ENSMSPG00010024802	protein coding gene	Chr2:1589588-1616844 (-)
WSB/EiJ	ENSIUOG00005022490	protein coding gene	Chr2:1578359-1607732 (-)

Human Ortholog

PRPF18, pre-mRNA processing factor 18

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PRPF18, pre-mRNA processing factor 18
Synonyms

hPrp18, PRP18
Links

HGNC:17351

NCBI Gene ID: 8559

UniProt: Q99633
Chr Location

10p13; chr10:13586939-13668445 (+) GRCh38

MGI Vertebrate Homology

Prpf18 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PRPF18
Gene Tree

Prpf18

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

2
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

14 strains or lines available

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All GO Annotations

8
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

810
Tissues

80
cDNA Data

85
Literature Summary

5

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase prpf18

ZFIN prpf18

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All Sequences

65
RefSeq

4
UniProt

5
CCDS

CCDS15657.1

Ensembl

ENSMUSG00000039449 (Evidence)
NCBI Gene

67229

			Length	Strain/Species	Flank
genomic	ENSMUSG00000039449	Ensembl Gene Model \| MGI Sequence Detail	30056	C57BL/6J	± kb
transcript	ENSMUST00000035721	Ensembl \| MGI Sequence Detail	3522	Not Applicable
polypeptide	ENSMUSP00000041428	Ensembl \| MGI Sequence Detail	342	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000013276 pre-mRNA-splicing factor 18

(term hierarchy)
InterPro Domains

IPR014906 Pre-mRNA processing factor 4 (PRP4)-like

IPR039979 Pre-mRNA-splicing factor 18

IPR004098 Prp18

IPR036285 PRP4-like superfamily

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All nucleic 87

cDNA 85

Primer pair 2

Microarray probesets 2

Summaries

All 34

Developmental Gene Expression 5

Gene Ontology 4

Phenotypes 7
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Prpf18:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr22387	Chr2:4656898-4656951 (-)	-1 bp
Tssr22386	Chr2:4656871-4656888 (-)	44 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24