About   Help   FAQ
Plekho1
Gene Detail
 Symbol
Name
ID
Plekho1
pleckstrin homology domain containing, family O member 1
MGI:1914470
Synonyms 2810052M02Rik, CKIP-1, Jza2, JZA-20
Feature Type protein coding gene
Genetic Map
Chromosome 3
41.65 cM, cytoband F2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr3:95988429-95996001 bp, - strand
From VEGA annotation of GRCm38

  7573 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9448  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Plekho1

Human
homologs
Human Homolog PLEKHO1, pleckstrin homology domain containing, family O member 1
NCBI Gene ID 51177
neXtProt AC  NX_Q53GL0
Human Synonyms  CKIP-1, OC120
Human Chr (Location)  1q21.2; chr1:150149980-150159630 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit age-dependent increase in bone volume and increased osteoblast activity.
 
Interactions
Plekho1 interacts with 79 markers (Mir24-1, Mir24-2, Mir30c-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (3 annotations)
Component cytoplasm, membrane, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(68)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(68) cDNA(68)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000022186 (Evidence)
Ensembl Gene ModelENSMUSG00000015745 (Evidence)
Entrez Gene67220 (Evidence)
UniGene458147
DFCITC1577843
NIA Mouse Gene IndexU024376
Consensus CDS ProjectCCDS17627.1
International Mouse Knockout Project StatusPlekho1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022186 VEGA Gene Model | MGI Sequence Detail 7573 C57BL/6J ±  kb
transcript OTTMUST00000052703 VEGA | MGI Sequence Detail 1931 Not Applicable 
polypeptide OTTMUSP00000025022 VEGA | MGI Sequence Detail 408 Not Applicable 

For the selected sequences
All sequences(42) RefSeq(4) UniProt(4)
Polymorphisms SNPs within 2kb(26 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
Protein Ontology PR:000012865 pleckstrin homology domain-containing family O member 1
References (Earliest) J:33282 Chevray PM, et al., Protein interaction cloning in yeast: identification of mammalian proteins that react with the leucine zipper of Jun. Proc Natl Acad Sci U S A. 1992 Jul 1;89(13):5789-93
(Latest) J:204422 Zhang L, et al., Integrated analysis of genomics and proteomics reveals that CKIP-1 is a novel macrophage migration regulator. Biochem Biophys Res Commun. 2013 Jul 5;436(3):382-7
All references(33)
Other
accession IDs
MGD-MRK-35895, MGI:107424

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/09/2014
MGI 5.19
The Jackson Laboratory