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Med18 Gene Detail
Summary
  • Symbol
    Med18
  • Name
    mediator complex subunit 18
  • Synonyms
    2810046C01Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914469
    NCBI Gene: 67219
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:132458731-132463921 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 65.40 cM, cytoband D3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    102 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914469
protein coding gene Chr4:132458729-132463921 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028871
protein coding gene Chr4:134618621-134623798 (-)
A/J MGP_AJ_G0028830
protein coding gene Chr4:129020454-129025649 (-)
AKR/J MGP_AKRJ_G0028783
protein coding gene Chr4:132648374-132653565 (-)
BALB/cJ MGP_BALBcJ_G0028853
protein coding gene Chr4:129632489-129637684 (-)
C3H/HeJ MGP_C3HHeJ_G0028567
protein coding gene Chr4:132912868-132918063 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029295
protein coding gene Chr4:139478828-139484018 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026566
protein coding gene Chr4:122093770-122099770 (-)
CAST/EiJ MGP_CASTEiJ_G0028000
protein coding gene Chr4:130989871-130996833 (-)
CBA/J MGP_CBAJ_G0028533
protein coding gene Chr4:143052738-143057951 (-)
DBA/2J MGP_DBA2J_G0028682
protein coding gene Chr4:129441610-129446596 (-)
FVB/NJ MGP_FVBNJ_G0028649
protein coding gene Chr4:128290402-128295369 (-)
LP/J MGP_LPJ_G0028783
protein coding gene Chr4:134774487-134779677 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028675
protein coding gene Chr4:147647996-147653191 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029333
protein coding gene Chr4:133057308-133063895 (-)
PWK/PhJ MGP_PWKPhJ_G0027721
protein coding gene Chr4:126127028-126132668 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027547
protein coding gene Chr4:128910102-128915132 (-)
WSB/EiJ MGP_WSBEiJ_G0028080
protein coding gene Chr4:133241023-133247475 (-)



Homology
more
  • Human Ortholog
    MED18, mediator complex subunit 18
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MED18, mediator complex subunit 18
    Orthology source: HomoloGene, HGNC
  • Synonyms
    p28b, SRB5
  • Links
    NCBI Gene ID: 54797
    neXtProt AC: NX_Q9BUE0
    UniProt: Q9BUE0

  • Chr Location
    1p35.3; chr1:28329002-28335967 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 9756
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: MED18
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000066042 Ensembl Gene Model | MGI Sequence Detail 5191 C57BL/6J ±  kb
transcript ENSMUST00000102567 Ensembl | MGI Sequence Detail 1675 Not Applicable  
polypeptide ENSMUSP00000099627 Ensembl | MGI Sequence Detail 208 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 10
    cDNA 10

    Microarray probesets 3
References
more
  • Summaries
    All 40
    Gene Ontology 7
    Phenotypes 13
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:237787 Liu X, et al., Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA. BMC Immunol. 2016 Aug 02;17(1):25

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory