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Eif2s2 Gene Detail
Summary
  • Symbol
    Eif2s2
  • Name
    eukaryotic translation initiation factor 2, subunit 2 (beta)
  • Synonyms
    2810026E11Rik, 38kDa, D2Ertd303e, EIF2, EIF2B
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914454
    NCBI Gene: 67204
  • Gene Overview
    MyGene.info: EIF2S2
Location & Maps
more
  • Sequence Map
    Chr2:154871410-154892935 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      21526 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 76.89 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    EIF2S2, eukaryotic translation initiation factor 2 subunit beta
  • Vertebrate Orthologs
    9
  • Human Ortholog
    EIF2S2, eukaryotic translation initiation factor 2 subunit beta
    Orthology source: HomoloGene
  • Synonyms
    EIF2, EIF2B, eIF-2-beta, EIF2beta, PPP1R67
  • Links
    NCBI Gene ID: 8894
    neXtProt AC: NX_P20042

  • Chr Location
    20q11.2; chr20:34088309-34112279 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 1 allele in 2 genetic backgrounds
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    98
  • Chemically and radiation induced
    1
  • Gene trapped
    95
  • Targeted
    2
  • Genomic Mutations
    1 involving Eif2s2
  • Incidental Mutations
Mice homozygous for a gene trap allele exhibit embryonic lethallity prior to E8.5. Mice heterozygous for a gene trap allele exhibit reduced incidence of testicular germ cell tumors.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015977 VEGA Gene Model | MGI Sequence Detail 21526 C57BL/6J ±  kb
transcript OTTMUST00000038021 VEGA | MGI Sequence Detail 2542 Not Applicable  
polypeptide OTTMUSP00000017054 VEGA | MGI Sequence Detail 331 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    121 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000006972 eukaryotic translation initiation factor 2 subunit 2
  • InterPro Domains
    IPR002735 Translation initiation factor IF2/IF5
    IPR016189 Translation initiation factor IF2/IF5, N-terminal
    IPR016190 Translation initiation factor IF2/IF5, zinc-binding
Molecular
Reagents
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  • All nucleic 26
    cDNA 23
    Primer pair 2
    Other 1

    Microarray probesets 9
Other
Accession IDs
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MGI:1098790, MGI:2138753, MGI:2138795, MGI:2138820, MGI:2139418
References
more
  • Summaries
    All 41
    Developmental Gene Expression 3
    Gene Ontology 5
    Phenotypes 31
  • Earliest
    J:2300 Charles CH, et al., cDNA sequence of a growth factor-inducible immediate early gene and characterization of its encoded protein. Oncogene. 1992 Jan;7(1):187-90
  • Latest
    J:174767 Tang F, et al., Deterministic and stochastic allele specific gene expression in single mouse blastomeres. PLoS One. 2011;6(6):e21208

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory