Nde1
Gene Detail

Symbol Name ID

Nde1 nuclear distribution gene E homolog 1 (A nidulans) MGI:1914453

Synonyms

2810027M15Rik, mNudE

Feature Type

protein coding gene

Genetic Map

Chromosome 16

9.70 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr16:14163275-14192928 bp, + strand From VEGA annotation of GRCm38   29654 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:32354  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Nde1

Human homologs

Human Homolog		NDE1, nudE nuclear distribution E homolog 1 (A. nidulans)
NCBI Gene ID		54820
neXtProt AC		NX_Q9NXR1
Human Synonyms		HOM-TES-87, LIS4, NUDE, NUDE1
Human Chr (Location)		16p13.11; chr16:15737124-15820210 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human NDE1

Alleles and phenotypes

All alleles(52) : Targeted(4) Gene trapped(48)
 

Homozygous null mutants have a small brain with fewer neurons in the cerebral cortex and very thin superficial cortical layers.

 

Gene Ontology (GO) classifications

All GO classifications: (34 annotations)

Process	cell cycle, cell differentiation, ...
Component	centrosome, chromosome, ...
Function	identical protein binding, microtubule binding, ...

External Resources: FuncBase

Expression

Literature Summary: (8 records)
Data Summary: Results (291)    Tissues (18)    Images (26)
Theiler Stages: 1, 5, 23, 24, 28

Assay Type	Results
RNA in situ	276
Western blot	12
RT-PCR	3

cDNA source data(14)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(15) cDNA(14) Primer pair(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000027034 (Evidence)
Ensembl Gene Model	ENSMUSG00000022678 (Evidence)
Entrez Gene	67203 (Evidence)
DFCI	TC1572834, TC1594596, TC1676319, TC1689631, TC1710685
DoTS	DT.110726689, DT.40179647, DT.491142, DT.94148831
NIA Mouse Gene Index	U016840, U188509
Consensus CDS Project	CCDS37263.2, CCDS49770.1
International Mouse Knockout Project Status	Nde1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000027034	VEGA Gene Model | MGI Sequence Detail	29654	C57BL/6J
transcript	OTTMUST00000066825	VEGA | MGI Sequence Detail	2287	Not Applicable
polypeptide	OTTMUSP00000033544	VEGA | MGI Sequence Detail	344	Not Applicable

All sequences(73) RefSeq(4) UniProt(3)

Polymorphisms

SNPs(110 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR006964	NUDE protein, C-terminal
Protein Ontology	PR:000011051	nuclear distribution protein nudE 1

References

(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:184033 Pawlisz AS, et al., Three-dimensional regulation of radial glial functions by Lis1-Nde1 and dystrophin glycoprotein complexes. PLoS Biol. 2011 Oct;9(10):e1001172
All references(49)

Other accession IDs

MGI:2146576, MGI:2146676