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Nde1 Gene Detail
Summary
  • Symbol
    Nde1
  • Name
    nudE neurodevelopment protein 1
  • Synonyms
    2810027M15Rik, mNudE
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914453
    NCBI Gene: 67203
  • Gene Overview
    MyGene.info: NDE1
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:14163275-14192928 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 9.70 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    164 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914453
protein coding gene Chr16:14163275-14192928 (.)
129S1/SvImJ MGP_129S1SvImJ_G0022542
protein coding gene Chr16:11211893-11241231 (+)
A/J MGP_AJ_G0022504
protein coding gene Chr16:10573087-10602549 (+)
AKR/J MGP_AKRJ_G0022480
protein coding gene Chr16:11043252-11072891 (+)
BALB/cJ MGP_BALBcJ_G0022508
protein coding gene Chr16:10749031-10778853 (+)
C3H/HeJ MGP_C3HHeJ_G0022275
protein coding gene Chr16:11140822-11170618 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022957
protein coding gene Chr16:11356871-11391237 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020477
protein coding gene Chr16:10664934-10695377 (+)
CAST/EiJ MGP_CASTEiJ_G0021802
protein coding gene Chr16:11157563-11191275 (+)
CBA/J MGP_CBAJ_G0022244
protein coding gene Chr16:11912297-11941882 (+)
DBA/2J MGP_DBA2J_G0022375
protein coding gene Chr16:10574533-10604065 (+)
FVB/NJ MGP_FVBNJ_G0022351
protein coding gene Chr16:10556660-10586272 (+)
LP/J MGP_LPJ_G0022443
protein coding gene Chr16:11092883-11123431 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022373
protein coding gene Chr16:11529340-11559149 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022970
protein coding gene Chr16:11014847-11046505 (+)
PWK/PhJ MGP_PWKPhJ_G0021544
protein coding gene Chr16:10828437-10859462 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021373
protein coding gene Chr16:11002466-11034308 (+)
WSB/EiJ MGP_WSBEiJ_G0021850
protein coding gene Chr16:11030305-11060561 (+)



Homology
more
  • Human Ortholog
    NDE1, nudE neurodevelopment protein 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NDE1, nudE neurodevelopment protein 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HOM-TES-87, LIS4, MHAC, NDE, NUDE, NUDE1
  • Links
    NCBI Gene ID: 54820
    neXtProt AC: NX_Q9NXR1
    UniProt: Q9NXR1

  • Chr Location
    16p13.11; chr16:15643267-15726353 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 32354
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: NDE1
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human NDE1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    8 phenotypes from multigenic genotypes
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mutants have a small brain with fewer neurons in the cerebral cortex and very thin superficial cortical layers.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 67203 NCBI Gene Model | MGI Sequence Detail 29654 C57BL/6J ±  kb
    transcript NM_001285503 RefSeq | MGI Sequence Detail 2422 C57BL/6  
    polypeptide Q9CZA6 UniProt | EBI | MGI Sequence Detail 344 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 113
      cDNA 112
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2146576, MGI:2146676
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 10
      Gene Ontology 16
      Phenotypes 14
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:226332 Maskey D, et al., Cell cycle-dependent ubiquitylation and destruction of NDE1 by CDK5-FBW7 regulates ciliary length. EMBO J. 2015 Oct 1;34(19):2424-40

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory