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Nde1
Gene Detail
Symbol

Name
ID
Nde1
nuclear distribution gene E homolog 1 (A nidulans)
MGI:1914453
Synonyms
2810027M15Rik, mNudE
Feature Type
protein coding gene
Genetic Map
Chromosome 16
9.70 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr16:14163275-14192928 bp, + strand
From VEGA annotation of GRCm38

  29654 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32354  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: NDE1
Gene Tree: Nde1

Human
homologs
NDE1, nudE neurodevelopment protein 1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 54820
neXtProt AC: NX_Q9NXR1

Human Synonyms: HOM-TES-87, LIS4, MHAC, NDE, NUDE, NUDE1

Human Chr (Location): 16p13.11; chr16:15643267-15726353 (+)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human NDE1

Mutations,
alleles, and
phenotypes
All mutations/alleles(52) : Gene trapped(48) Targeted(4)
Incidental mutations (data from Mutagenetix , CvDC )
 
Homozygous null mutants have a small brain with fewer neurons in the cerebral cortex and very thin superficial cortical layers.
 
Interactions
Nde1 interacts with 190 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (49 annotations)
Process cell cycle, cell differentiation, ...
Component cell, centrosome, ...
Function identical protein binding, microtubule binding, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (291)    Tissues (18)    Images (26)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 276
Western blot 12
RT-PCR 3
cDNA source data(111)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase nde1    NEW 
Molecular
reagents
All nucleic(112) cDNA(111) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000027034 (Evidence)
Ensembl Gene Model ENSMUSG00000022678 (Evidence)
Entrez Gene 67203 (Evidence)
UniGene 24105
DFCI TC1676319, TC1710685, TC1594596, TC1689631, TC1572834
DoTS DT.110726689, DT.40179647, DT.94148831, DT.491142
NIA Mouse Gene Index U188509, U016840
Consensus CDS Project CCDS37263.2, CCDS49770.1, CCDS70688.1
International Mouse Phenotyping Consortium Status Nde1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027034 VEGA Gene Model | MGI Sequence Detail 29654 C57BL/6J ±  kb
transcript OTTMUST00000066825 VEGA | MGI Sequence Detail 2287 Not Applicable 
polypeptide OTTMUSP00000033544 VEGA | MGI Sequence Detail 344 Not Applicable 

For the selected sequences
All sequences(79) RefSeq(10) UniProt(3)
Polymorphisms
SNPs within 2kb(165 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006964 NUDE protein, C-terminal
Protein Ontology PR:000011051 nuclear distribution protein nudE homolog 1
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:218049 Houlihan SL, et al., The scaffold protein Nde1 safeguards the brain genome during S phase of early neural progenitor differentiation. Elife. 2014;3:e03297
All references(55)
Other
accession IDs
MGI:2146576, MGI:2146676

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory