About   Help   FAQ
Nde1
Gene Detail
 Symbol
Name
ID
Nde1
nuclear distribution gene E homolog 1 (A nidulans)
MGI:1914453
Synonyms 2810027M15Rik, mNudE
Feature Type protein coding gene
Genetic Map
Chromosome 16
9.70 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr16:14163275-14192928 bp, + strand
From VEGA annotation of GRCm38

  29654 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32354  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Nde1

Human
homologs
Human Homolog NDE1, nudE neurodevelopment protein 1
NCBI Gene ID 54820
neXtProt AC  NX_Q9NXR1
Human Synonyms  HOM-TES-87, LIS4, MHAC, NDE, NUDE, NUDE1
Human Chr (Location)  16p13.11; chr16:15643267-15726353 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human NDE1
Mutations,
alleles, and
phenotypes
All mutations/alleles(52) : Gene trapped(48) Targeted(4)
Incidental mutations (data from Mutagenetix )
 
Homozygous null mutants have a small brain with fewer neurons in the cerebral cortex and very thin superficial cortical layers.
 
Interactions
Nde1 interacts with 190 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (38 annotations)
Process cell cycle, cell differentiation, ...
Component cell, centrosome, ...
Function identical protein binding, microtubule binding, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (291)    Tissues (18)    Images (26)
Theiler Stages: 1, 5, 23, 24, 28
Assay TypeResults
RNA in situ 276
Western blot 12
RT-PCR 3
cDNA source data(111)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(112) cDNA(111) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000027034 (Evidence)
Ensembl Gene ModelENSMUSG00000022678 (Evidence)
Entrez Gene67203 (Evidence)
UniGene24105
DFCITC1572834, TC1594596, TC1676319, TC1689631, TC1710685
DoTSDT.110726689, DT.40179647, DT.491142, DT.94148831
NIA Mouse Gene IndexU016840, U188509
Consensus CDS ProjectCCDS37263.2, CCDS49770.1, CCDS70688.1
International Mouse Knockout Project StatusNde1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027034 VEGA Gene Model | MGI Sequence Detail 29654 C57BL/6J ±  kb
transcript OTTMUST00000066825 VEGA | MGI Sequence Detail 2287 Not Applicable 
polypeptide OTTMUSP00000033544 VEGA | MGI Sequence Detail 344 Not Applicable 

For the selected sequences
All sequences(79) RefSeq(10) UniProt(3)
Polymorphisms SNPs within 2kb(165 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006964 NUDE protein, C-terminal
Protein Ontology PR:000011051 nuclear distribution protein nudE homolog 1
References (Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:197131 Lanctot AA, et al., Spatially dependent dynamic MAPK modulation by the nde1-lis1-brap complex patterns Mammalian CNS. Dev Cell. 2013 May 13;25(3):241-55
All references(52)
Other
accession IDs
MGI:2146576, MGI:2146676

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/19/2014
MGI 5.19
The Jackson Laboratory