Pfdn1 MGI Mouse Gene Detail - MGI:1914449

Symbol

Pfdn1
Name

prefoldin 1
Synonyms

2700086I23Rik

Feature Type

protein coding gene
IDs

MGI:1914449
NCBI Gene: 67199
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr18:36536732-36587548 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 18, 19.46 cM
Mapping Data

2 experiments

SNPs within 2kb

182 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914449	protein coding gene	Chr18:36536729-36587577 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0024277	protein coding gene	Chr18:34795592-34853200 (-)
A/J	MGP_AJ_G0024243	protein coding gene	Chr18:33579179-33630597 (-)
AKR/J	MGP_AKRJ_G0024211	protein coding gene	Chr18:34505835-34560089 (-)
BALB/cJ	MGP_BALBcJ_G0024243	protein coding gene	Chr18:33627791-33681315 (-)
C3H/HeJ	MGP_C3HHeJ_G0024010	protein coding gene	Chr18:34582486-34633286 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0024684	protein coding gene	Chr18:36014315-36076211 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022124	protein coding gene	Chr18:33671821-33724477 (-)
CAST/EiJ	MGP_CASTEiJ_G0023485	protein coding gene	Chr18:34577870-34633883 (-)
CBA/J	MGP_CBAJ_G0023978	protein coding gene	Chr18:37095152-37151706 (-)
DBA/2J	MGP_DBA2J_G0024110	protein coding gene	Chr18:33202910-33253936 (-)
FVB/NJ	MGP_FVBNJ_G0024077	protein coding gene	Chr18:32902217-32952723 (-)
LP/J	MGP_LPJ_G0024192	protein coding gene	Chr18:34828518-34881813 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024105	protein coding gene	Chr18:38296865-38365174 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024733	protein coding gene	Chr18:34381108-34445311 (-)
PWK/PhJ	MGP_PWKPhJ_G0023229	protein coding gene	Chr18:33448877-33499586 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0023036	protein coding gene	Chr18:34635503-34691405 (-)
WSB/EiJ	MGP_WSBEiJ_G0023548	protein coding gene	Chr18:34305331-34360320 (-)

Human Ortholog

PFDN1, prefoldin subunit 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PFDN1, prefoldin subunit 1
Synonyms

PDF, PFD1
Links

HGNC:8866

NCBI Gene ID: 5201

neXtProt AC: NX_O60925

UniProt: O60925
Chr Location

5q31.3; chr5:140245035-140303113 (-) GRCh38

MGI Vertebrate Homology

Pfdn1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PFDN1
Gene Tree

Pfdn1

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Phenotype Summary

41 phenotypes from 2 alleles in 2 genetic backgrounds
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

612
Endonuclease-mediated

1
Gene trapped

608
Targeted

3
Find Mice (IMSR)

173 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a gene trapped allele display reduced birth size, slow weight gain, loss of neuron tracts in the brain, uncoordinated movement, impaired B and T cell development and function, mucus clearance defects, hydrocephaly, and premature deathpreceded by physical wasting.

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All GO Annotations

15
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

713
Tissues

7
cDNA Data

113
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase pfdn1

ZFIN pfdn1

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All Sequences

48
RefSeq

2
UniProt

6
CCDS

CCDS29152.1

Ensembl

ENSMUSG00000024346 (Evidence)
NCBI Gene

67199

			Length	Strain/Species	Flank
genomic	67199	NCBI Gene Model \| MGI Sequence Detail	50817	C57BL/6J	± kb
transcript	NM_026027	RefSeq \| MGI Sequence Detail	1077	C57BL/6
polypeptide	Q9CWM4	UniProt \| EBI \| MGI Sequence Detail	122	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000012572 prefoldin subunit 1

(term hierarchy)
InterPro Domains

IPR009053 Prefoldin

IPR002777 Prefoldin beta-like

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All nucleic 113

cDNA 113

Microarray probesets 5

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MGI:2147167, MGI:2147328

Summaries

All 36

Developmental Gene Expression 2

Gene Ontology 4

Phenotypes 13
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

TSS for Pfdn1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr152935	Chr18:36587576-36587588 (-)	-34 bp
Tssr152934	Chr18:36587540-36587569 (-)	-7 bp
Tssr152933	Chr18:36586883-36586888 (-)	662 bp
Tssr152932	Chr18:36549646-36549651 (-)	37,899 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23