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Pfdn1
Gene Detail
Symbol

Name
ID
Pfdn1
prefoldin 1
MGI:1914449
Synonyms
2700086I23Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 18
19.46 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr18:36403679-36454495 bp, - strand
From NCBI annotation of GRCm38

  50817 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37644  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: prefoldin subunit 1
Gene Tree: Pfdn1

Human
homologs
Human Homolog PFDN1, prefoldin subunit 1
NCBI Gene ID 5201
neXtProt AC  NX_O60925
Human Synonyms  PDF, PFD1
Human Chr (Location)  5q31; chr5:140245050-140303104 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(694) : Gene trapped(691) Targeted(3)
 
Mice homozygous for a gene trapped allele display reduced birth size, slow weight gain, loss of neuron tracts in the brain, uncoordinated movement, impaired B and T cell development and function, mucus clearance defects, hydrocephaly, and premature death preceded by physical wasting.
 
Interactions
Pfdn1 interacts with 97 markers (Mir10a, Mir10b, Mir17, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process actin cytoskeleton organization, B cell activation, ...
Component prefoldin complex
Function unfolded protein binding
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (7)    Tissues (7)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 7
cDNA source data(112)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(112) cDNA(112)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000024346 (Evidence)
Entrez Gene67199 (Evidence)
UniGene30184
DFCITC1576413
DoTSDT.110770901, DT.536055, DT.97402876, DT.94371722
NIA Mouse Gene IndexU038334
Consensus CDS ProjectCCDS29152.1
International Mouse Knockout Project StatusPfdn1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 67199 NCBI Gene Model | MGI Sequence Detail 50817 C57BL/6J ±  kb
transcript NM_026027 RefSeq | MGI Sequence Detail 1077 C57BL/6 
polypeptide Q9CWM4 UniProt | EBI | MGI Sequence Detail 122 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(2) UniProt(7)
Polymorphisms
SNPs within 2kb(181 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR009053 Prefoldin
InterPro IPR002777 Prefoldin beta-like
Protein Ontology PR:000012572 prefoldin subunit 1
Graphical View of Protein Domain Structure
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(36)
Other
accession IDs
MGI:2147167, MGI:2147328

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory