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Cdt1 Gene Detail
Summary
  • Symbol
    Cdt1
  • Name
    chromatin licensing and DNA replication factor 1
  • Synonyms
    2610318F11Rik, Ris2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914427
    NCBI Gene: 67177
Location & Maps
more
  • Sequence Map
    Chr8:122568015-122573128 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5114 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    CDT1, chromatin licensing and DNA replication factor 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CDT1, chromatin licensing and DNA replication factor 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    DUP, RIS2
  • Links
    NCBI Gene ID: 81620
    neXtProt AC: NX_Q9H211

  • Chr Location
    16q24.3; chr16:88803778-88809258 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human CDT1 associations

Human Disease Mouse Models
       Meier-Gorlin Syndrome 4; MGORS4   OMIM: 613804
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    2 phenotype references
  • All Mutations and Alleles
    3
  • Spontaneous
    1
  • Targeted
    2
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000006585 Ensembl Gene Model | MGI Sequence Detail 5114 C57BL/6J ±  kb
transcript ENSMUST00000006760 Ensembl | MGI Sequence Detail 2189 Not Applicable  
polypeptide ENSMUSP00000006760 Ensembl | MGI Sequence Detail 557 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    100 from dbSNP Build 137
Protein
Information
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Molecular
Reagents
less
  • All nucleic 113
    cDNA 112
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
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MGI:2142800, MGI:2142842
References
more
  • Summaries
    All 39
    Developmental Gene Expression 7
    Gene Ontology 7
    Phenotypes 2
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:223504 Coulombe P, et al., A spontaneous Cdt1 mutation in 129 mouse strains reveals a regulatory domain restraining replication licensing. Nat Commun. 2013;4:2065

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory