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Cdt1
Gene Detail
Symbol

Name
ID
Cdt1
chromatin licensing and DNA replication factor 1
MGI:1914427
Synonyms
2610318F11Rik, Ris2
Feature Type
protein coding gene
Genetic Map
Chromosome 8
71.91 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr8:122568015-122573128 bp, + strand
From Ensembl annotation of GRCm38

  5114 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32650  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CDT1
Gene Tree: Cdt1

Human
homologs
CDT1, chromatin licensing and DNA replication factor 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 81620
neXtProt AC: NX_Q9H211

Human Synonyms: DUP, RIS2

Human Chr (Location): 16q24.3; chr16:88803778-88809258 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human CDT1

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Cdt1 interacts with 65 markers (Mir19a, Mir19b-1, Mir19b-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process cell cycle, DNA replication, ...
Component nucleoplasm, nucleus
Function DNA binding, protein binding
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (43)    Tissues (9)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 40
RT-PCR 3
cDNA source data(112)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase cdt1 ; ZFIN cdt1    NEW 
Molecular
reagents
All nucleic(113) cDNA(112) Primer pair(1)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000006585 (Evidence)
Entrez Gene 67177 (Evidence)
UniGene 21873
DFCI TC1572631, TC1595378, TC1597941, TC1718956
DoTS DT.101278617, DT.533047, DT.94278451
NIA Mouse Gene Index U009914
PDB 2KLO, 2RQQ, 2ZXX, 3A4C
Consensus CDS Project CCDS22741.1
International Mouse Phenotyping Consortium Status Cdt1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000006585 Ensembl Gene Model | MGI Sequence Detail 5114 C57BL/6J ±  kb
transcript ENSMUST00000006760 Ensembl | MGI Sequence Detail 2189 Not Applicable 
polypeptide ENSMUSP00000006760 Ensembl | MGI Sequence Detail 557 Not Applicable 

For the selected sequences
All sequences(49) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(100 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR014939 CDT1 Geminin-binding domain-like
Protein Ontology PR:000005293 DNA replication factor Cdt1
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:170314 Albino D, et al., Gene expression profiling identifies eleven DNA repair genes down-regulated during mouse neural crest cell migration. Int J Dev Biol. 2011;55(1):65-72
All references(40)
Other
accession IDs
MGI:2142800, MGI:2142842

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory