Lpar6 MGI Mouse Gene Detail - MGI:1914418 - lysophosphatidic acid receptor 6

Lpar6 Gene Detail

Symbol

Lpar6
Name

lysophosphatidic acid receptor 6
Synonyms

2610302I02Rik, P2ry5, P2y5

Feature Type

protein coding gene
IDs

MGI:1914418
NCBI Gene: 67168
Gene Overview

MyGene.info: LPAR6

Sequence Map

Chr14:73237895-73243294 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

5400 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 38.75 cM
Mapping Data

1 experiment

Human Ortholog

LPAR6, lysophosphatidic acid receptor 6

Vertebrate Orthologs

10

Human Ortholog

LPAR6, lysophosphatidic acid receptor 6
Orthology source: HomoloGene, HGNC
Synonyms

ARWH1, HYPT8, LAH3, P2RY5, P2Y5
Links

HGNC:15520

NCBI Gene ID: 10161

neXtProt AC: NX_P43657
Chr Location

13q14; chr13:48411045-48444704 (-) GRCh38.p2

HomoloGene

Vertebrate Homology Class 55925
1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
HCOP

human homology predictions: LPAR6
Protein SuperFamily

LPAR4-like receptor
Gene Tree

Lpar6

Diseases

1 with human LPAR6 associations

				Human Disease	Mouse Models
				Hypotrichosis 8; HYPT8 OMIM: 278150

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

17
Chemically induced (other)

1
Gene trapped

10
Targeted

6
Genomic Mutations

1 involving Lpar6
Incidental Mutations

APF , CvDC

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All GO Annotations

15
GO References

4

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

66
Tissues

45
cDNA Data

54
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO
Other Vertebrate Links

Xenbase lpar6

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Lpar6 interacts with 165 markers (Mir1b, Mir17, Mir19a, ...) View All

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All Sequences

22
RefSeq

2
UniProt

1
CCDS

CCDS27268.1
UniGene

390681

			Length	Strain/Species	Flank
genomic	OTTMUSG00000036134	VEGA Gene Model \| MGI Sequence Detail	5400	C57BL/6J	± kb
transcript	OTTMUST00000092880	VEGA \| MGI Sequence Detail	5400	Not Applicable
polypeptide	OTTMUSP00000051426	VEGA \| MGI Sequence Detail	344	Not Applicable

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SNPs within 2kb

89 from dbSNP Build 142

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UniProt

1 Sequence
Protein Ontology

PR:000001632 oleoyl-L-alpha-lysophosphatidic acid receptor
InterPro Domains

IPR017452 GPCR, rhodopsin-like, 7TM

IPR000276 G protein-coupled receptor, rhodopsin-like

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All nucleic 55

cDNA 54

Primer pair 1

Microarray probesets 4

Summaries

All 35

Developmental Gene Expression 3

Gene Ontology 4

Phenotypes 11
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:230717 Takeda A, et al., Fibroblastic reticular cell-derived lysophosphatidic acid regulates confined intranodal T-cell motility. Elife. 2016;5:e10561

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 09/27/2016 MGI 6.05