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Lpar6 Gene Detail
Summary
  • Symbol
    Lpar6
  • Name
    lysophosphatidic acid receptor 6
  • Synonyms
    2610302I02Rik, P2ry5, P2y5
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914418
    NCBI Gene: 67168
  • Gene Overview
    MyGene.info: LPAR6
Location & Maps
more
  • Sequence Map
    Chr14:73237895-73243294 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5400 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    LPAR6, lysophosphatidic acid receptor 6
  • Vertebrate Orthologs
    10
  • Human Ortholog
    LPAR6, lysophosphatidic acid receptor 6
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ARWH1, HYPT8, LAH3, P2RY5, P2Y5
  • Links
    NCBI Gene ID: 10161
    neXtProt AC: NX_P43657

  • Chr Location
    13q14; chr13:48411045-48444704 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human LPAR6 associations

Human Disease Mouse Models
       Hypotrichosis 8; HYPT8   OMIM: 278150
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    17
  • Chemically induced (other)
    1
  • Gene trapped
    10
  • Targeted
    6
  • Genomic Mutations
    1 involving Lpar6
  • Incidental Mutations
    APF , CvDC
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036134 VEGA Gene Model | MGI Sequence Detail 5400 C57BL/6J ±  kb
transcript OTTMUST00000092880 VEGA | MGI Sequence Detail 5400 Not Applicable  
polypeptide OTTMUSP00000051426 VEGA | MGI Sequence Detail 344 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    89 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000001632 oleoyl-L-alpha-lysophosphatidic acid receptor
  • InterPro Domains
    IPR017452 GPCR, rhodopsin-like, 7TM
    IPR000276 G protein-coupled receptor, rhodopsin-like
Molecular
Reagents
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  • All nucleic 55
    cDNA 54
    Primer pair 1

    Microarray probesets 4
References
more
  • Summaries
    All 33
    Developmental Gene Expression 2
    Gene Ontology 3
    Phenotypes 11
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:196844 Furuta D, et al., Lysophosphatidic acid induces neurite branch formation through LPA3. Mol Cell Neurosci. 2012 May;50(1):21-34

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory