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Rnf141 Gene Detail
Summary
  • Symbol
    Rnf141
  • Name
    ring finger protein 141
  • Synonyms
    2610110L04Rik, ZFP36, ZNF230
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914400
    NCBI Gene: 67150
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:110800432-110844457 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 57.87 cM, cytoband F2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    509 from dbSNP Build 142
  • Strain Annotations
    16
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914400
protein coding gene Chr7:110799469-110844457 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032860
protein coding gene Chr7:114305028-114350077 (-)
A/J no annotation
AKR/J MGP_AKRJ_G0032775
protein coding gene Chr7:114259471-114306921 (-)
BALB/cJ MGP_BALBcJ_G0032848
protein coding gene Chr7:111157710-111201667 (-)
C3H/HeJ MGP_C3HHeJ_G0032558
protein coding gene Chr7:114274186-114320178 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033354
protein coding gene Chr7:119034836-119080844 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030326
protein coding gene Chr7:113082883-113126847 (-)
CAST/EiJ MGP_CASTEiJ_G0031886
protein coding gene Chr7:105862152-105907255 (-)
CBA/J MGP_CBAJ_G0032531
protein coding gene Chr7:122919713-122968611 (-)
DBA/2J MGP_DBA2J_G0032683
protein coding gene Chr7:109560083-109604063 (-)
FVB/NJ MGP_FVBNJ_G0032636
protein coding gene Chr7:109416932-109460987 (-)
LP/J MGP_LPJ_G0032777
protein coding gene Chr7:115825076-115868796 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032668
protein coding gene Chr7:124585892-124631152 (-)
NZO/HlLtJ no annotation
PWK/PhJ MGP_PWKPhJ_G0031593
protein coding gene Chr7:102402531-102446512 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031441
protein coding gene Chr7:100029525-100077832 (-)
WSB/EiJ MGP_WSBEiJ_G0031999
protein coding gene Chr7:114137193-114182983 (-)



Homology
more
  • Human Ortholog
    RNF141, ring finger protein 141
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RNF141, ring finger protein 141
    Orthology source: HomoloGene, HGNC
  • Synonyms
    RFP141, ZFP26, ZNF230
  • Links
    NCBI Gene ID: 50862
    neXtProt AC: NX_Q8WVD5
    UniProt: Q8WVD5

  • Chr Location
    11p15.4; chr11:10511678-10541227 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted allele exhibit decreased litter size but normal spermatogeness and testes weight.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000030788 Ensembl Gene Model | MGI Sequence Detail 44026 C57BL/6J ±  kb
transcript ENSMUST00000106682 Ensembl | MGI Sequence Detail 1101 Not Applicable  
polypeptide ENSMUSP00000102293 Ensembl | MGI Sequence Detail 230 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 124
    cDNA 123
    Primer pair 1

    Microarray probesets 6
Other
Accession IDs
less
MGI:2141850, MGI:2142144
References
more
  • Summaries
    All 40
    Developmental Gene Expression 4
    Gene Ontology 4
    Phenotypes 11
  • Earliest
    J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
  • Latest
    J:198086 Liu Y, et al., A new mutant transcript generated in Znf230 exon 2 knockout mice reveals a potential exon structure in the targeting vector sequence. Acta Biochim Biophys Sin (Shanghai). 2013 Feb;45(2):123-8

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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Funding Information
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last database update
10/01/2019
MGI 6.14
The Jackson Laboratory