Rnf141 MGI Mouse Gene Detail - MGI:1914400

Symbol

Rnf141
Name

ring finger protein 141
Synonyms

2610110L04Rik, ZFP36, ZNF230

Feature Type

protein coding gene
IDs

MGI:1914400
NCBI Gene: 67150
Alliance

genome feature page
Transcription Start Sites

1 TSS

Sequence Map

Chr7:110399639-110443664 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 57.87 cM, cytoband F2
Mapping Data

3 experiments

SNPs within 2kb

1160 from dbSNP Build 142
Strain Annotations

27

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914400	protein coding gene	Chr7:110398676-110443664 (-)
129S1/SvImJ	ENSMUSGG00200054544	protein coding gene	Chr7:96957341-96967593 (-)
129S1/SvImJ	ENSMUSG00200032798	protein coding gene	Chr7:96972477-96979463 (-)
A/J	ENSMUSGG00195055202	protein coding gene	Chr7:101452330-101462580 (-)
A/J	ENSMUSG00195031694	protein coding gene	Chr7:101467464-101474440 (-)
AKR/J	ENSMUSG00220033134	protein coding gene	Chr7:94871003-94877979 (-)
AKR/J	ENSMUSGG00220054581	protein coding gene	Chr7:94855869-94866119 (-)
BALB/cJ	ENSMUSG00180037454	protein coding gene	Chr7:98144042-98151028 (-)
BALB/cJ	ENSMUSGG00180055068	protein coding gene	Chr7:98128906-98139158 (-)
C3H/HeJ	ENSMUSG00175047998	protein coding gene	Chr7:98779917-98786901 (-)
C3H/HeJ	ENSMUSGG00175054567	protein coding gene	Chr7:98764779-98775033 (-)
C57BL/6NJ	ENSMUSG00215049000	protein coding gene	Chr7:98084725-98091713 (-)
C57BL/6NJ	ENSMUSGG00215055267	protein coding gene	Chr7:98069589-98079841 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030326	protein coding gene	Chr7:113082883-113126847 (-)
CAST/EiJ	no annotation
CBA/J	ENSMUSG00210042060	protein coding gene	Chr7:98606957-98613943 (-)
CBA/J	ENSMUSGG00210054499	protein coding gene	Chr7:98591821-98602073 (-)
DBA/2J	ENSMUSGG00185057699	protein coding gene	Chr7:102941972-102952224 (-)
DBA/2J	ENSMUSG00185020716	protein coding gene	Chr7:102957108-102964094 (-)
FVB/NJ	ENSMUSG00205046285	protein coding gene	Chr7:98569349-98576335 (-)
FVB/NJ	ENSMUSGG00205054062	protein coding gene	Chr7:98554213-98564465 (-)
JF1/MsJ	no annotation
LP/J	ENSMUSGG00230055868	protein coding gene	Chr7:109043070-109053322 (-)
LP/J	ENSMUSG00230044287	protein coding gene	Chr7:109058206-109065192 (-)
NOD/ShiLtJ	ENSMUSG00190040734	protein coding gene	Chr7:98772271-98778731 (-)
NOD/ShiLtJ	ENSMUSGG00190055071	protein coding gene	Chr7:98757271-98767535 (-)
NZO/HlLtJ	ENSMUSG00225015815	protein coding gene	Chr7:107275787-107282781 (-)
NZO/HlLtJ	ENSMUSGG00225055604	protein coding gene	Chr7:107260652-107270902 (-)
PWK/PhJ	no annotation
SPRET/EiJ	ENSMSPG00010039405	protein coding gene	Chr7:98256434-98286922 (-)
WSB/EiJ	no annotation

Human Ortholog

RNF141, ring finger protein 141

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RNF141, ring finger protein 141
Synonyms

RFP141, ZFP26, ZNF230
Links

HGNC:21159

NCBI Gene ID: 50862

UniProt: Q8WVD5
Chr Location

11p15.4; chr11:10511673-10541334 (-) GRCh38

MGI Vertebrate Homology

Rnf141 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RNF141
Gene Tree

Rnf141

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

1
Endonuclease-mediated

1
Radiation induced

1
Targeted

3
Genomic Mutations

2 involving Rnf141
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

12 strains or lines available

Mice homozygous for a targeted allele exhibit decreased litter size but normal spermatogeness and testes weight.

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All GO Annotations

7
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

694
Tissues

62
cDNA Data

123
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA RNF141

Xenbase rnf141

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All Sequences

112
RefSeq

36
UniProt

9
CCDS

CCDS40086.1

Ensembl

ENSMUSG00000030788 (Evidence)
NCBI Gene

67150

			Length	Strain/Species	Flank
genomic	ENSMUSG00000030788	Ensembl Gene Model \| MGI Sequence Detail	44026	C57BL/6J	± kb
transcript	ENSMUST00000177236	Ensembl \| MGI Sequence Detail	4032	Not Applicable
polypeptide	ENSMUSP00000134781	Ensembl \| MGI Sequence Detail	230	Not Applicable

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UniProt

9 Sequences
Protein Ontology

PR:000014087 RING finger protein 141

(term hierarchy)
InterPro Domains

IPR047126 RING finger protein 141-like

IPR043400 RNF141, RING finger, HC subclass

IPR013083 Zinc finger, RING/FYVE/PHD-type

IPR001841 Zinc finger, RING-type

IPR017907 Zinc finger, RING-type, conserved site

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All nucleic 124

cDNA 123

Primer pair 1

Microarray probesets 6

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MGI:2141850, MGI:2142144

Summaries

All 43

Developmental Gene Expression 4

Gene Ontology 5

Phenotypes 12
Earliest

J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
Latest

J:198086 Liu Y, et al., A new mutant transcript generated in Znf230 exon 2 knockout mice reveals a potential exon structure in the targeting vector sequence. Acta Biochim Biophys Sin (Shanghai). 2013 Feb;45(2):123-8

TSS for Rnf141:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr74268	Chr7:110443583-110443658 (-)	43 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24