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Fbxo5
Gene Detail
Symbol

Name
ID
Fbxo5
F-box protein 5
MGI:1914391
Synonyms
2510044I10Rik, Emi1, Fbxo31
Feature Type
protein coding gene
Genetic Map
Chromosome 10
1.91 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr10:5799160-5805600 bp, - strand
From VEGA annotation of GRCm38

  6441 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8135  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: FBXO5
Gene Tree: Fbxo5

Human
homologs
FBXO5, F-box protein 5
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 26271
neXtProt AC: NX_Q9UKT4

Human Synonyms: EMI1, FBX5, Fbxo31

Human Chr (Location): 6q25.2; chr6:152970519-152983605 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(47) : Gene trapped(43) Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a null mutation display embryonic lethality before implantation, impaired embryogenesis, and mitotic abnormalities.
 
Interactions
Fbxo5 interacts with 74 markers (Mir19b-1, Mir19b-2, Mir22, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process cell cycle, cell division, ...
Component cytoplasm, cytoskeleton, ...
Function metal ion binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (74)    Tissues (25)    Images (23)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 50
Western blot 6
RT-PCR 18
cDNA source data(45)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase fbxo5    NEW 
Molecular
reagents
All nucleic(47) cDNA(45) Primer pair(2)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000022756 (Evidence)
Ensembl Gene Model ENSMUSG00000019773 (Evidence)
Entrez Gene 67141 (Evidence)
UniGene 197520
DoTS DT.91342067, DT.97408276
NIA Mouse Gene Index U031497
Consensus CDS Project CCDS56683.1
International Mouse Phenotyping Consortium Status Fbxo5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022756 VEGA Gene Model | MGI Sequence Detail 6441 C57BL/6J ±  kb
transcript OTTMUST00000054631 VEGA | MGI Sequence Detail 1940 Not Applicable 
polypeptide OTTMUSP00000026092 VEGA | MGI Sequence Detail 421 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(46 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001810 F-box domain
Protein Ontology PR:000007417 F-box only protein 5
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(43)
Other
accession IDs
MGI:2143939

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory