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Mis12 Gene Detail
Summary
  • Symbol
    Mis12
  • Name
    MIS12 kinetochore complex component
  • Synonyms
    2510025F08Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914389
    NCBI Gene: 67139
  • Gene Overview
    MyGene.info: MIS12
Location & Maps
more
  • Sequence Map
    Chr11:71019611-71027371 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      7761 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 43.21 cM, cytoband B4
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    MIS12, MIS12, kinetochore complex component
  • Vertebrate Orthologs
    11
  • Human Ortholog
    MIS12, MIS12, kinetochore complex component
    Orthology source: HomoloGene, HGNC
  • Synonyms
    2510025F08Rik, hMis12, KNTC2AP, MTW1
  • Links
    NCBI Gene ID: 79003
    neXtProt AC: NX_Q9H081

  • Chr Location
    17p13.2; chr17:5486374-5490814 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 11429
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;2 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: MIS12
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotype references
  • All Mutations and Alleles
    14
  • Chemically induced (other)
    1
  • Gene trapped
    10
  • Targeted
    3
  • Genomic Mutations
    2 involving Mis12
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006078 VEGA Gene Model | MGI Sequence Detail 7761 C57BL/6J ±  kb
transcript OTTMUST00000013726 VEGA | MGI Sequence Detail 1416 Not Applicable  
polypeptide OTTMUSP00000006364 VEGA | MGI Sequence Detail 206 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    106 from dbSNP Build 142
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000010420 protein MIS12
  • InterPro Domains
    IPR008685 Centromere protein Mis12
Molecular
Reagents
less
  • All nucleic 10
    cDNA 10

    Microarray probesets 3
Other
Accession IDs
less
MGI:2144440
References
more
  • Summaries
    All 33
    Gene Ontology 5
    Phenotypes 15
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory