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Nrarp Gene Detail
Summary
  • Symbol
    Nrarp
  • Name
    Notch-regulated ankyrin repeat protein
  • Synonyms
    2700054M22Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914372
    NCBI Gene: 67122
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:25180758-25183339 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 17.05 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    11 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914372
protein coding gene Chr2:25180758-25183339 (.)
129S1/SvImJ MGP_129S1SvImJ_G0025421
protein coding gene Chr2:23039771-23042352 (+)
A/J MGP_AJ_G0025398
protein coding gene Chr2:22145633-22148214 (+)
AKR/J MGP_AKRJ_G0025368
protein coding gene Chr2:22899640-22902221 (+)
BALB/cJ MGP_BALBcJ_G0025394
protein coding gene Chr2:22267949-22270530 (+)
C3H/HeJ MGP_C3HHeJ_G0025155
protein coding gene Chr2:22829313-22831894 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025838
protein coding gene Chr2:23776322-23778903 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023249
protein coding gene Chr2:21076801-21079380 (+)
CAST/EiJ MGP_CASTEiJ_G0024618
protein coding gene Chr2:22713125-22715706 (+)
CBA/J MGP_CBAJ_G0025133
protein coding gene Chr2:24613863-24616444 (+)
DBA/2J MGP_DBA2J_G0025266
protein coding gene Chr2:22001912-22004493 (+)
FVB/NJ MGP_FVBNJ_G0025228
protein coding gene Chr2:21740690-21743271 (+)
LP/J MGP_LPJ_G0025352
protein coding gene Chr2:22991033-22993614 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025259
protein coding gene Chr2:24818411-24820992 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025897
protein coding gene Chr2:22846379-22848960 (+)
PWK/PhJ MGP_PWKPhJ_G0024366
protein coding gene Chr2:21812881-21815461 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024166
protein coding gene Chr2:22994577-22997156 (+)
WSB/EiJ MGP_WSBEiJ_G0024687
protein coding gene Chr2:22916650-22919231 (+)



Homology
more
  • Human Ortholog
    NRARP, NOTCH regulated ankyrin repeat protein
  • Vertebrate Orthologs
    9
  • Human Ortholog
    NRARP, NOTCH regulated ankyrin repeat protein
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 441478
    neXtProt AC: NX_Q7Z6K4
    UniProt: Q7Z6K4

  • Chr Location
    9q34.3; chr9:137299631-137302251 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    25 phenotypes from 3 alleles in 6 genetic backgrounds
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit delayed retinal vascularization due to increased vascular regression. Mice homozygous for a different knock-out allele exhibit vertebral and rib fusions.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 67122 NCBI Gene Model | MGI Sequence Detail 2582 C57BL/6J ±  kb
    transcript NM_025980 RefSeq | MGI Sequence Detail 2590 AKR/J  
    polypeptide Q91ZA8 UniProt | EBI | MGI Sequence Detail 114 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 54
      cDNA 49
      Primer pair 2
      Other 3

      Microarray probesets 5
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 25
      Gene Ontology 9
      Phenotypes 6
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:239835 Lee S, et al., Carbohydrate-binding protein CLEC14A regulates VEGFR-2- and VEGFR-3-dependent signals during angiogenesis and lymphangiogenesis. J Clin Invest. 2017 Feb 01;127(2):457-471

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory