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Mastl
Gene Detail
Symbol

Name
ID
Mastl
microtubule associated serine/threonine kinase-like
MGI:1914371
Synonyms
2700091H24Rik, THC2
Feature Type
protein coding gene
Genetic Map
Chromosome 2
15.23 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr2:23115606-23156024 bp, - strand
From VEGA annotation of GRCm38

  40419 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:12086  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: MASTL
Gene Tree: Mastl

Human
homologs
MASTL, microtubule associated serine/threonine kinase-like
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 84930
neXtProt AC: NX_Q96GX5

Human Synonyms: GREATWALL, GW, GWL, hGWL, MAST-L, THC2

Human Chr (Location): 10p12.1; chr10:27154824-27186920 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human MASTL

Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Gene trapped(8) Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a null mutation display embryonic lethality and mitotic abnormalities.
 
Interactions
Mastl interacts with 354 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process activation of anaphase-promoting complex activity involved in meiotic cell cycle, cell cycle, ...
Component centrosome, cleavage furrow, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (9)    Tissues (5)    Images (5)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 9
cDNA source data(48)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase mastl ; ZFIN mastl    NEW 
Molecular
reagents
All nucleic(48) cDNA(48)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000011632 (Evidence)
Ensembl Gene Model ENSMUSG00000026779 (Evidence)
Entrez Gene 67121 (Evidence)
UniGene 253721
DFCI TC1580427, TC1595854, TC1636829, TC1663520, TC1681105
DoTS DT.110668451, DT.110668461, DT.528477, DT.55224616, DT.94126043, DT.94253997
NIA Mouse Gene Index U043837
EC 2.7.11.1
Consensus CDS Project CCDS15727.1
International Mouse Phenotyping Consortium Status Mastl
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000011632 VEGA Gene Model | MGI Sequence Detail 40419 C57BL/6J ±  kb
transcript OTTMUST00000027217 VEGA | MGI Sequence Detail 5590 Not Applicable 
polypeptide OTTMUSP00000012380 VEGA | MGI Sequence Detail 865 Not Applicable 

For the selected sequences
All sequences(48) RefSeq(6) UniProt(1)
Polymorphisms
SNPs within 2kb(113 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000961 AGC-kinase, C-terminal
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000010199 microtubule-associated serine/threonine-protein kinase-like
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:215974 Adhikari D, et al., Mastl is required for timely activation of APC/C in meiosis I and Cdk1 reactivation in meiosis II. J Cell Biol. 2014 Sep 29;206(7):843-53
All references(41)
Other
accession IDs
MGI:2147807

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory