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Mastl
Gene Detail
 Symbol
Name
ID
Mastl
microtubule associated serine/threonine kinase-like
MGI:1914371
Synonyms 2700091H24Rik, THC2
Feature Type protein coding gene
Genetic Map
Chromosome 2
15.23 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr2:23115606-23156024 bp, - strand
From VEGA annotation of GRCm38

  40419 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:12086  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Mastl

Human
homologs
Human Homolog MASTL, microtubule associated serine/threonine kinase-like
NCBI Gene ID 84930
neXtProt AC  NX_Q96GX5
Human Synonyms  GREATWALL, GW, GWL, hGWL, MAST-L, THC2
Human Chr (Location)  10p12.1; chr10:27154824-27186919 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human MASTL
Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Gene trapped(8) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null mutation display embryonic lethality and mitotic abnormalities.
 
Interactions
Mastl interacts with 354 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process cell cycle, cell division, ...
Component centrosome, cleavage furrow, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (9)    Tissues (5)    Images (5)
Theiler Stages: 23
Assay TypeResults
RNA in situ 9
cDNA source data(48)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(48) cDNA(48)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000011632 (Evidence)
Ensembl Gene ModelENSMUSG00000026779 (Evidence)
Entrez Gene67121 (Evidence)
UniGene253721
DFCITC1580427, TC1595854, TC1636829, TC1663520, TC1681105
DoTSDT.110668451, DT.110668461, DT.528477, DT.55224616, DT.94126043, DT.94253997
NIA Mouse Gene IndexU043837
EC2.7.11.1
Consensus CDS ProjectCCDS15727.1
International Mouse Knockout Project StatusMastl
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000011632 VEGA Gene Model | MGI Sequence Detail 40419 C57BL/6J ±  kb
transcript OTTMUST00000027217 VEGA | MGI Sequence Detail 5590 Not Applicable 
polypeptide OTTMUSP00000012380 VEGA | MGI Sequence Detail 865 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(4) UniProt(1)
Polymorphisms SNPs within 2kb(113 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000961 AGC-kinase, C-terminal
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000010199 microtubule-associated serine/threonine-protein kinase-like
References (Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:201971 Alvarez-Fernandez M, et al., Greatwall is essential to prevent mitotic collapse after nuclear envelope breakdown in mammals. Proc Natl Acad Sci U S A. 2013 Oct 22;110(43):17374-9
All references(42)
Other
accession IDs
MGI:2147807

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory