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Trappc6a Gene Detail
Summary
  • Symbol
    Trappc6a
  • Name
    trafficking protein particle complex 6A
  • Synonyms
    1810073E21Rik, 4930519D19Rik, TRS33
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914341
    NCBI Gene: 67091
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:19508729-19516145 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 9.92 cM, cytoband A2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    36 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914341
protein coding gene Chr7:19508395-19516145 (.)
129S1/SvImJ MGP_129S1SvImJ_G0031781
protein coding gene Chr7:17524462-17537039 (+)
A/J MGP_AJ_G0031757
protein coding gene Chr7:17154473-17163157 (+)
AKR/J MGP_AKRJ_G0031683
protein coding gene Chr7:17630180-17640144 (+)
BALB/cJ MGP_BALBcJ_G0031762
protein coding gene Chr7:17361008-17368938 (+)
C3H/HeJ MGP_C3HHeJ_G0031484
protein coding gene Chr7:17892864-17901222 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032228
protein coding gene Chr7:18396443-18404352 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029294
protein coding gene Chr7:18805828-18812080 (+)
CAST/EiJ MGP_CASTEiJ_G0030828
protein coding gene Chr7:14329144-14337594 (+)
CBA/J MGP_CBAJ_G0031446
protein coding gene Chr7:19054526-19069193 (+)
DBA/2J MGP_DBA2J_G0031601
protein coding gene Chr7:17103165-17110837 (+)
FVB/NJ MGP_FVBNJ_G0031553
protein coding gene Chr7:16962024-16970561 (+)
LP/J MGP_LPJ_G0031684
protein coding gene Chr7:17844776-17855530 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031589
protein coding gene Chr7:18904260-18914434 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032256
protein coding gene Chr7:17233196-17242581 (+)
PWK/PhJ MGP_PWKPhJ_G0030551
protein coding gene Chr7:14202435-14211253 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030378
protein coding gene Chr7:11943373-11949872 (+)
WSB/EiJ MGP_WSBEiJ_G0030927
protein coding gene Chr7:17456909-17465770 (+)



Homology
more
  • Human Ortholog
    TRAPPC6A, trafficking protein particle complex 6A
  • Vertebrate Orthologs
    6
  • Human Ortholog
    TRAPPC6A, trafficking protein particle complex 6A
    Orthology source: HomoloGene, HGNC
  • Synonyms
    TRS33
  • Links
    NCBI Gene ID: 79090
    neXtProt AC: NX_O75865
    UniProt: O75865

  • Chr Location
    19q13.32; chr19:45162928-45178302 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mice exhibit pigmentation abnormalities including mosaic loss of coat pigment, patchy loss of pigmentation in the retinal pigmented epithelial layer, and abnormal melanosomes.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 67091 NCBI Gene Model | MGI Sequence Detail 7417 C57BL/6J ±  kb
transcript NM_025960 RefSeq | MGI Sequence Detail 827 C57BL/6  
polypeptide Q78XR0 UniProt | EBI | MGI Sequence Detail 159 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000016617 trafficking protein particle complex subunit 6A
  • InterPro Domains
    IPR024096 NO signalling/Golgi transport ligand-binding domain superfamily
    IPR007194 Transport protein particle (TRAPP) component
    IPR037992 TRAPP complex, Trs33 subunit
Molecular
Reagents
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  • All nucleic 8
    cDNA 8

    Microarray probesets 5
Other
Accession IDs
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MGI:1922355, MGI:2141982, MGI:3577867
References
more
  • Summaries
    All 29
    Gene Ontology 5
    Phenotypes 4
  • Earliest
    J:14372 Matthews RJ, et al., Identification of an additional member of the protein-tyrosine-phosphatase family: evidence for alternative splicing in the tyrosine phosphatase domain. Proc Natl Acad Sci U S A. 1990 Jun;87(12):4444-8
  • Latest
    J:238174 Chang JY, et al., Trafficking protein particle complex 6A delta (TRAPPC6ADelta) is an extracellular plaque-forming protein in the brain. Oncotarget. 2015 Feb 28;6(6):3578-89

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory