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Magt1 Gene Detail
Summary
  • Symbol
    Magt1
  • Name
    magnesium transporter 1
  • Synonyms
    2410001C15Rik, 2610529C04Rik, 2810482I07Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914325
    NCBI Gene: 67075
  • Gene Overview
    MyGene.info: MAGT1
  • Alliance
Location & Maps
more
  • Sequence Map
    ChrX:105968084-106011906 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      43823 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome X, 47.36 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    MAGT1, magnesium transporter 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    MAGT1, magnesium transporter 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    bA217H1.1, IAP, MRX95, OST3B, PRO0756, XMEN
  • Links
    NCBI Gene ID: 84061
    neXtProt AC: NX_Q9H0U3
    UniProt: Q9H0U3

  • Chr Location
    Xq21.1; chrX:77826364-77895568 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Magt1 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Male mice hemizygous for one gene trap allele exhibit decreased T cell number and increased B cell numbers with increased activation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018276 VEGA Gene Model | MGI Sequence Detail 43823 C57BL/6J ±  kb
transcript OTTMUST00000044163 VEGA | MGI Sequence Detail 4531 Not Applicable  
polypeptide OTTMUSP00000019852 VEGA | MGI Sequence Detail 368 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    155 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • InterPro Domains
    IPR006844 Magnesium transporter protein 1
    IPR021149 Oligosaccharyl transferase complex, subunit OST3/OST6
    IPR036249 Thioredoxin-like superfamily
Molecular
Reagents
less
  • All nucleic 13
    cDNA 13

    Microarray probesets 5
Other
Accession IDs
less
MGI:1914493, MGI:1917001
References
more
  • Summaries
    All 32
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 3
    Phenotypes 10
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:260923 Gotru SK, et al., Cutting Edge: Imbalanced Cation Homeostasis in MAGT1-Deficient B Cells Dysregulates B Cell Development and Signaling in Mice. J Immunol. 2018 Apr 15;200(8):2529-2534

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
06/05/2018
MGI 6.12
The Jackson Laboratory