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Magt1 Gene Detail
Summary
  • Symbol
    Magt1
  • Name
    magnesium transporter 1
  • Synonyms
    2410001C15Rik, 2610529C04Rik, 2810482I07Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914325
    NCBI Gene: 67075
  • Gene Overview
    MyGene.info: MAGT1
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:105968084-106011899 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 47.36 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    155 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914325
protein coding gene ChrX:105968084-106011906 (-)
129S1/SvImJ MGP_129S1SvImJ_G0036000
protein coding gene ChrX:102749881-102794161 (-)
A/J MGP_AJ_G0035979
protein coding gene ChrX:102519007-102563717 (-)
AKR/J MGP_AKRJ_G0035898
protein coding gene ChrX:105807917-105854809 (-)
BALB/cJ MGP_BALBcJ_G0035969
protein coding gene ChrX:101361881-101406216 (-)
C3H/HeJ MGP_C3HHeJ_G0035676
protein coding gene ChrX:103186817-103231346 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036496
protein coding gene ChrX:105683191-105728836 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033324
protein coding gene ChrX:99990533-100035769 (-)
CAST/EiJ MGP_CASTEiJ_G0034963
protein coding gene ChrX:87330501-87376332 (-)
CBA/J MGP_CBAJ_G0035651
protein coding gene ChrX:108998639-109044413 (-)
DBA/2J MGP_DBA2J_G0035805
protein coding gene ChrX:101812195-101856250 (-)
FVB/NJ MGP_FVBNJ_G0035746
protein coding gene ChrX:101120114-101169894 (-)
LP/J MGP_LPJ_G0035898
protein coding gene ChrX:103700648-103749795 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035778
protein coding gene ChrX:113680542-113730570 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036522
protein coding gene ChrX:102386442-102430540 (-)
PWK/PhJ MGP_PWKPhJ_G0034659
protein coding gene ChrX:84861911-84907971 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034488
protein coding gene ChrX:88069448-88114025 (-)
WSB/EiJ MGP_WSBEiJ_G0035101
protein coding gene ChrX:101087542-101133007 (-)



Homology
more
  • Human Ortholog
    MAGT1, magnesium transporter 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    MAGT1, magnesium transporter 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    bA217H1.1, IAP, MRX95, OST3B, PRO0756, XMEN
  • Links
    NCBI Gene ID: 84061
    neXtProt AC: NX_Q9H0U3
    UniProt: Q9H0U3

  • Chr Location
    Xq21.1; chrX:77826364-77895568 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Magt1 mouse models; 1 with human MAGT1 associations

Human Disease Mouse Models
      
IDs
View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Male mice hemizygous for one gene trap allele exhibit decreased T cell number and increased B cell numbers with increased activation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 67075 NCBI Gene Model | MGI Sequence Detail 43816 C57BL/6J ±  kb
transcript NM_001190409 RefSeq | MGI Sequence Detail 4524 C57BL/6  
polypeptide Q9CQY5 UniProt | EBI | MGI Sequence Detail 335 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    4 Sequences
  • InterPro Domains
    IPR006844 Magnesium transporter protein 1
    IPR021149 Oligosaccharyl transferase complex, subunit OST3/OST6
    IPR036249 Thioredoxin-like superfamily
Molecular
Reagents
less
  • All nucleic 15
    cDNA 15

    Microarray probesets 5
Other
Accession IDs
less
MGI:1914493, MGI:1917001
References
more
  • Summaries
    All 33
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 4
    Phenotypes 10
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:260923 Gotru SK, et al., Cutting Edge: Imbalanced Cation Homeostasis in MAGT1-Deficient B Cells Dysregulates B Cell Development and Signaling in Mice. J Immunol. 2018 Apr 15;200(8):2529-2534

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory