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Dzip1 Gene Detail
Summary
  • Symbol
    Dzip1
  • Name
    DAZ interacting protein 1
  • Synonyms
    2510025K24Rik, 2810422M04Rik, mKIAA0996
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914311
    NCBI Gene: 66573
  • Gene Overview
    MyGene.info: DZIP1
Location & Maps
more
  • Sequence Map
    Chr14:118875520-118925314 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      49795 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 62.56 cM, cytoband E4
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    DZIP1, DAZ interacting zinc finger protein 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DZIP1, DAZ interacting zinc finger protein 1
    Orthology source: HomoloGene
  • Synonyms
    DZIP, DZIPt1
  • Links
    NCBI Gene ID: 22873
    neXtProt AC: NX_Q86YF9

  • Chr Location
    13q32.1; chr13:95578202-95644706 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 45708
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: DZIP1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    1 images
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    1
  • Gene trapped
    3
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Dzip1
  • Incidental Mutations
Mice homozygous for a targeted allele lacking exons 2 and 3 exhibit partial embryonic lethality around E9.5, decreased embryo size, underdevelopment of the neural tube and somite and lack of primary cilia on MEFs.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000042156 Ensembl Gene Model | MGI Sequence Detail 49795 C57BL/6J ±  kb
transcript ENSMUST00000047208 Ensembl | MGI Sequence Detail 4476 Not Applicable  
polypeptide ENSMUSP00000039689 Ensembl | MGI Sequence Detail 852 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    426 from dbSNP Build 142
Protein
Information
less
  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000006790 zinc finger protein DZIP1
  • InterPro Domains
    IPR007087 Zinc finger, C2H2
    IPR015880 Zinc finger, C2H2-like
    IPR032714 Zinc finger protein DZIP1, N-terminal
Molecular
Reagents
less
  • All nucleic 21
    cDNA 20
    Primer pair 1

    Microarray probesets 6
Other
Accession IDs
less
MGI:1913823
References
more
  • Summaries
    All 40
    Developmental Gene Expression 9
    Gene Ontology 5
    Phenotypes 9
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:207249 Wang C, et al., Centrosomal protein DZIP1 regulates Hedgehog signaling by promoting cytoplasmic retention of transcription factor GLI3 and affecting ciliogenesis. J Biol Chem. 2013 Oct 11;288(41):29518-29

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory