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Ndc80 Gene Detail
Summary
  • Symbol
    Ndc80
  • Name
    NDC80 kinetochore complex component
  • Synonyms
    2610020P18Rik, HEC1, Kntc2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914302
    NCBI Gene: 67052
  • Gene Overview
    MyGene.info: NDC80
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:71496100-71526857 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 41.87 cM, cytoband E2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    193 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914302
protein coding gene Chr17:71496100-71526857 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024009
protein coding gene Chr17:73951927-73986512 (-)
A/J MGP_AJ_G0023967
protein coding gene Chr17:71711890-71744947 (-)
AKR/J MGP_AKRJ_G0023936
protein coding gene Chr17:72677620-72707872 (-)
BALB/cJ MGP_BALBcJ_G0023968
protein coding gene Chr17:71607241-71672338 (-)
C3H/HeJ MGP_C3HHeJ_G0023732
protein coding gene Chr17:73636330-73671516 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024414
protein coding gene Chr17:76647869-76685732 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021859
protein coding gene Chr17:67470242-67503995 (-)
CAST/EiJ MGP_CASTEiJ_G0023213
protein coding gene Chr17:74071668-74103968 (-)
CBA/J MGP_CBAJ_G0023707
protein coding gene Chr17:79849522-79884160 (-)
DBA/2J MGP_DBA2J_G0023836
protein coding gene Chr17:70368752-70399988 (-)
FVB/NJ MGP_FVBNJ_G0023802
protein coding gene Chr17:69836555-69875498 (-)
LP/J MGP_LPJ_G0023918
protein coding gene Chr17:74694191-74726455 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023830
protein coding gene Chr17:79691224-79724727 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024458
protein coding gene Chr17:73203688-73235489 (-)
PWK/PhJ MGP_PWKPhJ_G0022959
protein coding gene Chr17:69680357-69711749 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022770
protein coding gene Chr17:69908456-69942611 (-)
WSB/EiJ MGP_WSBEiJ_G0023280
protein coding gene Chr17:74014704-74068950 (-)



Homology
more
  • Human Ortholog
    NDC80, NDC80, kinetochore complex component
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NDC80, NDC80, kinetochore complex component
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HEC, HEC1, HsHec1, hsNDC80, KNTC2, TID3
  • Links
    NCBI Gene ID: 10403
    neXtProt AC: NX_O14777
    UniProt: O14777

  • Chr Location
    18p11.32; chr18:2571511-2616635 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 38141
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: NDC80
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 67052 NCBI Gene Model | MGI Sequence Detail 30758 C57BL/6J ±  kb
transcript NM_023294 RefSeq | MGI Sequence Detail 2201 C57BL/6  
polypeptide Q9D0F1 UniProt | EBI | MGI Sequence Detail 642 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 58
    cDNA 58

    Microarray probesets 3
Other
Accession IDs
less
MGI:3034956
References
more
  • Summaries
    All 37
    Gene Ontology 6
    Phenotypes 6
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:245683 Camlin NJ, et al., Kif4 Is Essential for Mouse Oocyte Meiosis. PLoS One. 2017;12(1):e0170650

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory