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Ndc80 Gene Detail
Summary
  • Symbol
    Ndc80
  • Name
    NDC80 kinetochore complex component
  • Synonyms
    2610020P18Rik, HEC1, Kntc2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914302
    NCBI Gene: 67052
  • Gene Overview
    MyGene.info: NDC80
Location & Maps
more
  • Sequence Map
    Chr17:71496100-71526857 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      30758 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    NDC80, NDC80, kinetochore complex component
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NDC80, NDC80, kinetochore complex component
    Orthology source: HGNC, HomoloGene
  • Synonyms
    HEC, HEC1, HsHec1, hsNDC80, KNTC2, TID3
  • Links
    NCBI Gene ID: 10403
    neXtProt AC: NX_O14777

  • Chr Location
    18p11.32; chr18:2571511-2616635 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 38141
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: NDC80
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotype references
  • All Mutations and Alleles
    13
  • Gene trapped
    11
  • Targeted
    2
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 67052 NCBI Gene Model | MGI Sequence Detail 30758 C57BL/6J ±  kb
transcript NM_023294 RefSeq | MGI Sequence Detail 2201 C57BL/6  
polypeptide Q9D0F1 UniProt | EBI | MGI Sequence Detail 642 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    193 from dbSNP Build 142
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000011050 kinetochore protein NDC80
  • InterPro Domains
    IPR005550 Kinetochore protein Ndc80
Molecular
Reagents
less
  • All nucleic 58
    cDNA 58

    Microarray probesets 3
Other
Accession IDs
less
MGI:3034956
References
more
  • Summaries
    All 34
    Gene Ontology 5
    Phenotypes 6
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:196442 Gui L, et al., Hec1-dependent cyclin B2 stabilization regulates the G2-M transition and early prometaphase in mouse oocytes. Dev Cell. 2013 Apr 15;25(1):43-54

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory