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Vma21 Gene Detail
Summary
  • Symbol
    Vma21
  • Name
    VMA21 vacuolar H+-ATPase homolog (S. cerevisiae)
  • Synonyms
    2610030H06Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914298
    NCBI Gene: 67048
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:70856368-70868312 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 37.07 cM, cytoband C2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    54 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914298
 protein coding gene ChrX:70856368-70883363 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035785
 protein coding gene ChrX:67488219-67514382 (+)
A/J MGP_AJ_G0035769
 protein coding gene ChrX:67728704-67757493 (+)
AKR/J MGP_AKRJ_G0035691
 protein coding gene ChrX:69543793-69569959 (+)
BALB/cJ MGP_BALBcJ_G0035756
 protein coding gene ChrX:66785777-66809566 (+)
C3H/HeJ MGP_C3HHeJ_G0035459
 protein coding gene ChrX:68002966-68028778 (+)
C57BL/6NJ no annotation
CAROLI/EiJ MGP_CAROLIEiJ_G0033133
 protein coding gene ChrX:66960820-66984083 (+)
CAST/EiJ MGP_CASTEiJ_G0034751
 protein coding gene ChrX:53393236-53420114 (+)
CBA/J MGP_CBAJ_G0035434
 protein coding gene ChrX:71488536-71514356 (+)
DBA/2J MGP_DBA2J_G0035587
 protein coding gene ChrX:67206271-67234286 (+)
FVB/NJ MGP_FVBNJ_G0035538
 protein coding gene ChrX:66568215-66590723 (+)
LP/J MGP_LPJ_G0035676
 protein coding gene ChrX:68360737-68391817 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035573
 protein coding gene ChrX:74030418-74057489 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036307
 protein coding gene ChrX:67342851-67366996 (+)
PWK/PhJ MGP_PWKPhJ_G0034451
 protein coding gene ChrX:51410206-51434027 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034286
 protein coding gene ChrX:54308920-54332488 (+)
WSB/EiJ MGP_WSBEiJ_G0034893
 protein coding gene ChrX:66667185-66697468 (+)



Homology
more
  • Human Ortholog
    VMA21, vacuolar ATPase assembly factor VMA21
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    VMA21, vacuolar ATPase assembly factor VMA21
  • Synonyms
    MEAX, XMEA
  • Links
    NCBI Gene ID: 203547
    neXtProt AC: NX_Q3ZAQ7
    UniProt: Q3ZAQ7

  • Chr Location
    Xq28; chrX:151396515-151409364 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human VMA21 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    5
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    16
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 67048 NCBI Gene Model | MGI Sequence Detail 11945 C57BL/6J ±  kb
transcript NM_001290781 RefSeq | MGI Sequence Detail 4496 C57BL/6  
polypeptide Q78T54 UniProt | EBI | MGI Sequence Detail 101 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000030224 vacuolar ATPase assembly integral membrane protein VMA21
    (term hierarchy)
  • InterPro Domains
    IPR019013 Vacuolar ATPase assembly integral membrane protein Vma21
Molecular
Reagents
less
  • All nucleic 16
    cDNA 16

    Microarray probesets 10
Other
Accession IDs
less
MGI:2147916
References
more
  • Summaries
    All 24
    Developmental Gene Expression 1
    Gene Ontology 3
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:343515 Cocchiararo I, et al., Identification of a muscle-specific isoform of VMA21 as a potent actor in X-linked myopathy with excessive autophagy pathogenesis. Hum Mol Genet. 2023 Dec 1;32(24):3374-3389
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory