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Rars Gene Detail
Summary
  • Symbol
    Rars
  • Name
    arginyl-tRNA synthetase
  • Synonyms
    2610011N19Rik, 2610037E21Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914297
    NCBI Gene: 104458
  • Gene Overview
    MyGene.info: RARS
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:35808381-35834506 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 21.96 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    175 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914297
protein coding gene Chr11:35808381-35834528 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018157
protein coding gene Chr11:34219501-34249223 (-)
A/J MGP_AJ_G0018130
protein coding gene Chr11:32934978-32961126 (-)
AKR/J MGP_AKRJ_G0018094
protein coding gene Chr11:33926181-33952325 (-)
BALB/cJ MGP_BALBcJ_G0018099
protein coding gene Chr11:33098450-33124598 (-)
C3H/HeJ MGP_C3HHeJ_G0017912
protein coding gene Chr11:33886332-33912475 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018553
protein coding gene Chr11:35259799-35285924 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016208
protein coding gene Chr11:31387269-31416776 (-)
CAST/EiJ MGP_CASTEiJ_G0017476
protein coding gene Chr11:33870201-33898115 (-)
CBA/J MGP_CBAJ_G0017885
protein coding gene Chr11:36944817-36970965 (-)
DBA/2J MGP_DBA2J_G0017995
protein coding gene Chr11:32678634-32704777 (-)
FVB/NJ MGP_FVBNJ_G0017989
protein coding gene Chr11:32530306-32556423 (-)
LP/J MGP_LPJ_G0018067
protein coding gene Chr11:34429742-34455890 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018013
protein coding gene Chr11:37672027-37699718 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018592
protein coding gene Chr11:33952115-33978502 (-)
PWK/PhJ MGP_PWKPhJ_G0017257
protein coding gene Chr11:32766031-32792715 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017049
protein coding gene Chr11:33718183-33746835 (-)
WSB/EiJ MGP_WSBEiJ_G0017525
protein coding gene Chr11:33724832-33750947 (-)



Homology
more
  • Human Ortholog
    RARS, arginyl-tRNA synthetase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RARS, arginyl-tRNA synthetase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ArgRS, DALRD1, HLD9
  • Links
    NCBI Gene ID: 5917
    neXtProt AC: NX_P54136
    UniProt: P54136

  • Chr Location
    5q34; chr5:168486458-168519306 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 68281
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: RARS
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human RARS associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000018848 Ensembl Gene Model | MGI Sequence Detail 26126 C57BL/6J ±  kb
transcript ENSMUST00000018992 Ensembl | MGI Sequence Detail 2109 Not Applicable  
polypeptide ENSMUSP00000018992 Ensembl | MGI Sequence Detail 660 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000013742 arginine--tRNA ligase, cytoplasmic
  • EC
  • InterPro Domains
    IPR009080 Aminoacyl-tRNA synthetase, class Ia, anticodon-binding
    IPR001412 Aminoacyl-tRNA synthetase, class I, conserved site
    IPR001278 Arginine-tRNA ligase
    IPR035684 Arginyl-tRNA synthetase, catalytic core domain
    IPR005148 Arginyl tRNA synthetase N-terminal domain
    IPR036695 Arginyl tRNA synthetase N-terminal domain superfamily
    IPR008909 DALR anticodon binding
    IPR014729 Rossmann-like alpha/beta/alpha sandwich fold
Molecular
Reagents
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  • All nucleic 251
    cDNA 249
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
less
MGI:1924077, MGI:2144362, MGI:2144591
References
more
  • Summaries
    All 39
    Developmental Gene Expression 2
    Gene Ontology 8
    Phenotypes 10
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory