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Ift27 Gene Detail
Summary
  • Symbol
    Ift27
  • Name
    intraflagellar transport 27
  • Synonyms
    2600013G09Rik, Rabl4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914292
    NCBI Gene: 67042
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:78159463-78174107 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 36.92 cM, cytoband E2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    173 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914292
protein coding gene Chr15:78159463-78174108 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022036
protein coding gene Chr15:78321843-78336462 (-)
A/J MGP_AJ_G0021996
protein coding gene Chr15:75592223-75606854 (-)
AKR/J MGP_AKRJ_G0021973
protein coding gene Chr15:77668871-77683341 (-)
BALB/cJ MGP_BALBcJ_G0022004
protein coding gene Chr15:75607802-75622433 (-)
C3H/HeJ MGP_C3HHeJ_G0021775
protein coding gene Chr15:77746465-77761097 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022446
protein coding gene Chr15:81395098-81409595 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019975
protein coding gene Chr15:72157025-72172247 (-)
CAST/EiJ MGP_CASTEiJ_G0021295
protein coding gene Chr15:78357393-78373575 (-)
CBA/J MGP_CBAJ_G0021740
protein coding gene Chr15:83905189-83919806 (-)
DBA/2J MGP_DBA2J_G0021868
protein coding gene Chr15:75088792-75103412 (-)
FVB/NJ MGP_FVBNJ_G0021847
protein coding gene Chr15:74081542-74096161 (-)
LP/J MGP_LPJ_G0021937
protein coding gene Chr15:78491564-78506195 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021867
protein coding gene Chr15:89096673-89116825 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022460
protein coding gene Chr15:77775132-77789818 (-)
PWK/PhJ MGP_PWKPhJ_G0021037
protein coding gene Chr15:75072759-75087554 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020873
protein coding gene Chr15:77536598-77551222 (-)
WSB/EiJ MGP_WSBEiJ_G0021348
protein coding gene Chr15:78093612-78108246 (-)



Homology
more
  • Human Ortholog
    IFT27, intraflagellar transport 27
  • Vertebrate Orthologs
    10
  • Human Ortholog
    IFT27, intraflagellar transport 27
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BBS19, RABL4, RAYL
  • Links
    NCBI Gene ID: 11020
    neXtProt AC: NX_Q9BW83
    UniProt: Q9BW83

  • Chr Location
    22q12.3; chr22:36758202-36776133 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human IFT27 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    43 phenotypes from 2 alleles in 2 genetic backgrounds
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice die shortly after birth showing multiple structural birth defects, including heart, lung, skeletal, and brain abnormalities, associated with abnormal Hedgehog signaling. Hair follicle development is severely impaired but formation of the ciliary axoneme is normal.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000016637 Ensembl Gene Model | MGI Sequence Detail 14645 C57BL/6J ±  kb
    transcript ENSMUST00000016781 Ensembl | MGI Sequence Detail 1013 Not Applicable  
    polypeptide ENSMUSP00000016781 Ensembl | MGI Sequence Detail 186 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 61
      cDNA 61

      Microarray probesets 4
    References
    more
    • Summaries
      All 63
      Developmental Gene Expression 5
      Diseases 1
      Gene Ontology 14
      Phenotypes 29
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:260436 Desai PB, et al., Ift25 is not a cystic kidney disease gene but is required for early steps of kidney development. Mech Dev. 2018 Jun;151:10-17

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory