About   Help   FAQ
Oma1 Gene Detail
Summary
  • Symbol
    Oma1
  • Name
    OMA1 zinc metallopeptidase
  • Synonyms
    2010001O09Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914263
    NCBI Gene: 67013
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:103313812-103371868 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 47.60 cM, cytoband C6
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    446 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914263
protein coding gene Chr4:103313209-103371869 (.)
129S1/SvImJ MGP_129S1SvImJ_G0028508
protein coding gene Chr4:103731742-103797533 (+)
A/J MGP_AJ_G0028471
protein coding gene Chr4:100109245-100167970 (+)
AKR/J MGP_AKRJ_G0028418
protein coding gene Chr4:102543445-102608413 (+)
BALB/cJ MGP_BALBcJ_G0028490
protein coding gene Chr4:100306886-100366697 (+)
C3H/HeJ MGP_C3HHeJ_G0028204
protein coding gene Chr4:103317186-103374615 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028930
protein coding gene Chr4:107643360-107707123 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026221
protein coding gene Chr4:95462186-95517374 (+)
CAST/EiJ MGP_CASTEiJ_G0027640
protein coding gene Chr4:101081705-101144166 (+)
CBA/J MGP_CBAJ_G0028173
protein coding gene Chr4:111050936-111123910 (+)
DBA/2J MGP_DBA2J_G0028321
protein coding gene Chr4:99773686-99830337 (+)
FVB/NJ MGP_FVBNJ_G0028288
protein coding gene Chr4:98616161-98672984 (+)
LP/J MGP_LPJ_G0028422
protein coding gene Chr4:104009022-104063228 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028315
protein coding gene Chr4:116495930-116558772 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028965
protein coding gene Chr4:102752262-102821583 (+)
PWK/PhJ MGP_PWKPhJ_G0027366
protein coding gene Chr4:97975878-98034397 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027190
protein coding gene Chr4:100167573-100228681 (+)
WSB/EiJ MGP_WSBEiJ_G0027720
protein coding gene Chr4:102926139-102986640 (+)



Homology
more
  • Human Ortholog
    OMA1, OMA1 zinc metallopeptidase
  • Vertebrate Orthologs
    9
  • Human Ortholog
    OMA1, OMA1 zinc metallopeptidase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    2010001O09Rik, DAB1, MPRP1, MPRP-1, peptidase, YKR087C, ZMPOMA1
  • Links
    NCBI Gene ID: 115209
    neXtProt AC: NX_Q96E52
    UniProt: Q96E52

  • Chr Location
    1p32.2-p32.1; chr1:58480719-58546799 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 12070
    1 human;1 mouse;1 rat;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: OMA1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    29 phenotypes from 1 allele in 1 genetic background
    2 phenotypes from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted allele exhibit increased susceptibility to diet-induced obesity and defective thermogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000035069 Ensembl Gene Model | MGI Sequence Detail 58057 C57BL/6J ±  kb
    transcript ENSMUST00000035780 Ensembl | MGI Sequence Detail 1915 Not Applicable  
    polypeptide ENSMUSP00000045269 Ensembl | MGI Sequence Detail 521 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 40
      cDNA 40

      Microarray probesets 3
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 2
      Gene Ontology 6
      Phenotypes 15
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:260499 Acin-Perez R, et al., Ablation of the stress protease OMA1 protects against heart failure in mice. Sci Transl Med. 2018 Mar 28;10(434)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory