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Oma1
Gene Detail
 Symbol
Name
ID
Oma1
OMA1 homolog, zinc metallopeptidase (S. cerevisiae)
MGI:1914263
Synonyms 2010001O09Rik
Feature Type protein coding gene
Genetic Map
Chromosome 4
47.60 cM, cytoband C6
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr4:103313812-103371868 bp, + strand
From VEGA annotation of GRCm38

  58057 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:12070  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Oma1

Human
homologs
Human Homolog OMA1, OMA1 zinc metallopeptidase
NCBI Gene ID 115209
neXtProt AC  NX_Q96E52
Human Synonyms  2010001O09Rik, DAB1, MPRP-1, peptidase, YKR087C, ZMPOMA1
Human Chr (Location)  1p32.2-p32.1; chr1:58480719-58546774 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted allele exhibit increased susceptibility to diet-induced obesity and defective thermogenesis.
 
Interactions
Oma1 interacts with 63 markers (Mir16-1, Mir27a, Mir27b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process cristae formation, diet induced thermogenesis, ...
Component integral component of membrane, membrane, ...
Function hydrolase activity, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (73)    Tissues (7)    Images (37)
Theiler Stages: 23
Assay TypeResults
RNA in situ 73
cDNA source data(39)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(39) cDNA(39)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000008073 (Evidence)
Ensembl Gene ModelENSMUSG00000035069 (Evidence)
Entrez Gene67013 (Evidence)
UniGene30021
DFCITC1578955, TC1614786
DoTSDT.101702884, DT.486236, DT.94127607
EC3.4.24.-
Consensus CDS ProjectCCDS18412.1
International Mouse Knockout Project StatusOma1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008073 VEGA Gene Model | MGI Sequence Detail 58057 C57BL/6J ±  kb
transcript OTTMUST00000018318 VEGA | MGI Sequence Detail 1915 Not Applicable 
polypeptide OTTMUSP00000008428 VEGA | MGI Sequence Detail 521 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(12) UniProt(1)
Polymorphisms SNPs within 2kb(439 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001915 Peptidase M48
Protein Ontology PR:000011635 metalloendopeptidase OMA1, mitochondrial
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:210969 Xiao X, et al., OMA1 mediates OPA1 proteolysis and mitochondrial fragmentation in experimental models of ischemic kidney injury. Am J Physiol Renal Physiol. 2014 Jun 1;306(11):F1318-26
All references(33)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory