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Oma1
Gene Detail
Symbol

Name
ID
Oma1
OMA1 homolog, zinc metallopeptidase (S. cerevisiae)
MGI:1914263
Synonyms
2010001O09Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 4
47.60 cM, cytoband C6
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr4:103313812-103371868 bp, + strand
From VEGA annotation of GRCm38

  58057 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:12070  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: OMA1
Gene Tree: Oma1

Human
homologs
OMA1, OMA1 zinc metallopeptidase
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 115209
neXtProt AC: NX_Q96E52

Human Synonyms: 2010001O09Rik, DAB1, MPRP-1, peptidase, YKR087C, ZMPOMA1

Human Chr (Location): 1p32.2-p32.1; chr1:58480719-58546799 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Targeted(9)
Genomic Mutations involving Oma1 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a targeted allele exhibit increased susceptibility to diet-induced obesity and defective thermogenesis.
 
Interactions
Oma1 interacts with 63 markers (Mir16-1, Mir27a, Mir27b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process cristae formation, diet induced thermogenesis, ...
Component integral component of membrane, membrane, ...
Function hydrolase activity, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (73)    Tissues (7)    Images (37)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 73
cDNA source data(39)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(39) cDNA(39)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000008073 (Evidence)
Ensembl Gene Model ENSMUSG00000035069 (Evidence)
Entrez Gene 67013 (Evidence)
UniGene 30021
DFCI TC1578955, TC1614786
DoTS DT.101702884, DT.94127607, DT.486236
EC 3.4.24.-
Consensus CDS Project CCDS18412.1
International Mouse Phenotyping Consortium Status Oma1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008073 VEGA Gene Model | MGI Sequence Detail 58057 C57BL/6J ±  kb
transcript OTTMUST00000018318 VEGA | MGI Sequence Detail 1915 Not Applicable 
polypeptide OTTMUSP00000008428 VEGA | MGI Sequence Detail 521 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(13) UniProt(1)
Polymorphisms
SNPs within 2kb(439 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001915 Peptidase M48
Protein Ontology PR:000011635 metalloendopeptidase OMA1, mitochondrial
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:215813 Anand R, et al., The i-AAA protease YME1L and OMA1 cleave OPA1 to balance mitochondrial fusion and fission. J Cell Biol. 2014 Mar 17;204(6):919-29
All references(35)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory