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Mettl6 Gene Detail
Summary
  • Symbol
    Mettl6
  • Name
    methyltransferase 6, methylcytidine
  • Synonyms
    1600013P15Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914261
    NCBI Gene: 67011
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:31195535-31216997 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 14, 19.12 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    57 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914261
protein coding gene Chr14:31180775-31217007 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021129
protein coding gene Chr14:24666229-24683375 (-)
A/J MGP_AJ_G0021077
protein coding gene Chr14:23734788-23751496 (-)
AKR/J MGP_AKRJ_G0021054
protein coding gene Chr14:24858455-24874685 (-)
BALB/cJ MGP_BALBcJ_G0021081
protein coding gene Chr14:23866045-23883150 (-)
C3H/HeJ MGP_C3HHeJ_G0020864
protein coding gene Chr14:24729436-24746070 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021513
protein coding gene Chr14:25640616-25658636 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019076
protein coding gene Chr14:23806785-23820928 (-)
CAST/EiJ MGP_CASTEiJ_G0020389
protein coding gene Chr14:24512529-24528609 (-)
CBA/J MGP_CBAJ_G0020831
protein coding gene Chr14:26611415-26633509 (-)
DBA/2J MGP_DBA2J_G0020953
protein coding gene Chr14:23772589-23789291 (-)
FVB/NJ MGP_FVBNJ_G0020937
protein coding gene Chr14:23725131-23742389 (-)
LP/J MGP_LPJ_G0021022
protein coding gene Chr14:24991695-25009564 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020963
protein coding gene Chr14:25870215-25886825 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021546
protein coding gene Chr14:24625327-24642020 (-)
PWK/PhJ MGP_PWKPhJ_G0020137
protein coding gene Chr14:23225179-23245809 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019961
protein coding gene Chr14:24226135-24244959 (-)
WSB/EiJ MGP_WSBEiJ_G0020444
protein coding gene Chr14:24688545-24705273 (-)



Homology
more
  • Human Ortholog
    METTL6, methyltransferase 6, tRNA N3-cytidine
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    METTL6, methyltransferase 6, tRNA N3-cytidine
  • Synonyms
    hMETTL6
  • Links
    NCBI Gene ID: 131965
    neXtProt AC: NX_Q8TCB7
    UniProt: Q8TCB7

  • Chr Location
    3p25.1; chr3:15381275-15440566 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit reduced 3-methylcytidine (m3C) methyltransferases modification of tRNA.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021891 Ensembl Gene Model | MGI Sequence Detail 21463 C57BL/6J ±  kb
transcript ENSMUST00000055303 Ensembl | MGI Sequence Detail 3946 Not Applicable  
polypeptide ENSMUSP00000077138 Ensembl | MGI Sequence Detail 282 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000010351 tRNA N(3)-methylcytidine methyltransferase METTL6
  • EC
  • InterPro Domains
    IPR013217 Methyltransferase type 12
    IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily
    IPR026113 tRNA N(3)-methylcytidine methyltransferase METTL2/6/8-like
Molecular
Reagents
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  • All nucleic 58
    cDNA 58

    Microarray probesets 4
Other
Accession IDs
less
MGI:2145663, MGI:2145737
References
more
  • Summaries
    All 34
    Developmental Gene Expression 3
    Gene Ontology 3
    Phenotypes 9
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:299743 Ignatova VV, et al., METTL6 is a tRNA m(3)C methyltransferase that regulates pluripotency and tumor cell growth. Sci Adv. 2020 Aug;6(35):eaaz4551

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory