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Khdc3
Gene Detail
 Symbol
Name
ID
Khdc3
KH domain containing 3, subcortical maternal complex member
MGI:1914241
Synonyms 2410004A20Rik, ecat1, FILIA
Feature Type protein coding gene
Genetic Map
Chromosome 9
40.08 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr9:73101836-73104438 bp, + strand
From VEGA annotation of GRCm38

  2603 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:49842  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Khdc3

Human
homologs
Human Homolog KHDC3L, KH domain containing 3-like, subcortical maternal complex member
NCBI Gene ID 154288
neXtProt AC  NX_Q587J8
Human Synonyms  C6orf221, ECAT1, HYDM2
Human Chr (Location)  6q13; chr6:73362671-73364175 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human KHDC3L
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
 
Homozygous null mice display a maternal effect defect in embryogenesis with delayed embryonic development and spindle abnormalities resulting in decreased litter sizes for homozygous females.
 
Interactions
Khdc3 interacts with 89 markers (Mir7-1, Mir22, Mir26a-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process cell cycle, mitotic spindle assembly checkpoint, ...
Component apical cortex, cell cortex, ...
Function protein binding, RNA binding
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (62)    Tissues (20)    Images (8)
Theiler Stages: 2, 3, 23, 28
Assay TypeResults
RNA in situ 14
Northern blot 12
RT-PCR 36
cDNA source data(7)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(8) cDNA(7) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000037515 (Evidence)
Ensembl Gene ModelENSMUSG00000092622 (Evidence)
Entrez Gene66991 (Evidence)
DFCITC1579965
DoTSDT.101212212, DT.488698
NIA Mouse Gene IndexU188888
PDB3V69
Consensus CDS ProjectCCDS23336.1
International Mouse Knockout Project StatusKhdc3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037515 VEGA Gene Model | MGI Sequence Detail 2603 C57BL/6J ±  kb
transcript OTTMUST00000096717 VEGA | MGI Sequence Detail 1681 Not Applicable 
polypeptide OTTMUSP00000054060 VEGA | MGI Sequence Detail 440 Not Applicable 

For the selected sequences
All sequences(45) RefSeq(8) UniProt(2)
Polymorphisms SNPs within 2kb(38 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000033493 KH domain-containing protein 3
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:184300 Wang J, et al., The N-terminus of FILIA forms an atypical KH domain with a unique extension involved in interaction with RNA. PLoS One. 2012;7(1):e30209
All references(33)
Other
accession IDs
MGI:2143072

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory