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Khdc3
Gene Detail
Symbol

Name
ID
Khdc3
KH domain containing 3, subcortical maternal complex member
MGI:1914241
Synonyms
2410004A20Rik, ecat1, FILIA
Feature Type
protein coding gene
Genetic Map
Chromosome 9
40.08 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr9:73101836-73104438 bp, + strand
From VEGA annotation of GRCm38

  2603 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:49842  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: KHDC3L
Gene Tree: Khdc3

Human
homologs
KHDC3L, KH domain containing 3-like, subcortical maternal complex member
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 154288
neXtProt AC: NX_Q587J8

Human Synonyms: C6orf221, ECAT1, HYDM2

Human Chr (Location): 6q13; chr6:73362211-73364175 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human KHDC3L

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
 
Homozygous null mice display a maternal effect defect in embryogenesis with delayed embryonic development and spindle abnormalities resulting in decreased litter sizes for homozygous females.
 
Interactions
Khdc3 interacts with 89 markers (Mir7-1, Mir22, Mir26a-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process cell cycle, mitotic spindle assembly, ...
Component apical cortex, cell cortex, ...
Function protein binding, RNA binding
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (62)    Tissues (20)    Images (8)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 14
Northern blot 12
RT-PCR 36
cDNA source data(7)
Other mouse links: GEO   Expression Atlas
Molecular
reagents
All nucleic(8) cDNA(7) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000037515 (Evidence)
Ensembl Gene Model ENSMUSG00000092622 (Evidence)
Entrez Gene 66991 (Evidence)
DFCI TC1579965
DoTS DT.101212212, DT.488698
NIA Mouse Gene Index U188888
PDB 3V69
Consensus CDS Project CCDS23336.1
International Mouse Phenotyping Consortium Status Khdc3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037515 VEGA Gene Model | MGI Sequence Detail 2603 C57BL/6J ±  kb
transcript OTTMUST00000096717 VEGA | MGI Sequence Detail 1681 Not Applicable 
polypeptide OTTMUSP00000054060 VEGA | MGI Sequence Detail 440 Not Applicable 

For the selected sequences
All sequences(45) RefSeq(8) UniProt(2)
Polymorphisms
SNPs within 2kb(38 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000033493 KH domain-containing protein 3
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:184300 Wang J, et al., The N-terminus of FILIA forms an atypical KH domain with a unique extension involved in interaction with RNA. PLoS One. 2012;7(1):e30209
All references(32)
Other
accession IDs
MGI:2143072

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory