Cdca7 MGI Mouse Gene Detail - MGI:1914203 - cell division cycle associated 7

Symbol

Cdca7
Name

cell division cycle associated 7
Synonyms

2310021G01Rik, JPO1

Feature Type

protein coding gene
IDs

MGI:1914203
NCBI Gene: 66953
Alliance

genome feature page
Transcription Start Sites

6 TSS

Sequence Map

Chr2:72306540-72317237 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 43.35 cM
Mapping Data

2 experiments

SNPs within 2kb

321 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914203	protein coding gene	Chr2:72306503-72317237 (+)
129S1/SvImJ	ENSMUSG00200035466	protein coding gene	Chr2:69374870-69385604 (+)
A/J	ENSMUSG00195022383	protein coding gene	Chr2:69521467-69532201 (+)
AKR/J	ENSMUSG00220034987	protein coding gene	Chr2:69486108-69496838 (+)
BALB/cJ	ENSMUSG00180038409	protein coding gene	Chr2:69475225-69485959 (+)
C3H/HeJ	ENSMUSG00175032750	protein coding gene	Chr2:69590229-69600968 (+)
C57BL/6NJ	ENSMUSG00215016425	protein coding gene	Chr2:69417431-69428165 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023652	protein coding gene	Chr2:67051255-67061632 (+)
CAST/EiJ	ENSTCUG00005008739	protein coding gene	Chr2:68897820-68908540 (+)
CBA/J	ENSMUSG00210035201	protein coding gene	Chr2:69633000-69643726 (+)
DBA/2J	ENSMUSG00185039659	protein coding gene	Chr2:69468750-69479485 (+)
FVB/NJ	ENSMUSG00205032371	protein coding gene	Chr2:68931517-68942247 (+)
JF1/MsJ	ENSUMUG00000004955	protein coding gene	Chr2:69123543-69134281 (+)
LP/J	ENSMUSG00230020416	protein coding gene	Chr2:71274693-71285423 (+)
NOD/ShiLtJ	ENSMUSG00190034071	protein coding gene	Chr2:69554289-69565019 (+)
NZO/HlLtJ	ENSMUSG00225014416	protein coding gene	Chr2:79018141-79028879 (+)
PWK/PhJ	ENSLUMG00010032447	protein coding gene	Chr2:69359733-69370409 (+)
SPRET/EiJ	ENSMSPG00010033594	protein coding gene	Chr2:70769740-70780528 (+)
WSB/EiJ	ENSIUOG00005017937	protein coding gene	Chr2:69596450-69607164 (+)

Human Ortholog

CDCA7, cell division cycle associated 7

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CDCA7, cell division cycle associated 7
Synonyms

ICF3, JPO1
Links

HGNC:14628

NCBI Gene ID: 83879

UniProt: Q9BWT1
Chr Location

2q31.1; chr2:173354820-173368997 (+) GRCh38

MGI Vertebrate Homology

Cdca7 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CDCA7
Gene Tree

Cdca7

Diseases

1 with human CDCA7 associations

				Human Disease	Mouse Models
				immunodeficiency-centromeric instability-facial anomalies syndrome 3 IDs immunodeficiency-centromeric instability-facial anomalies syndrome 3 DOID:0090010 ICD10CM:D84.8 OMIM:616910

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
3 phenotypes from multigenic genotypes
23 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

23
Chemically induced (other)

1
Endonuclease-mediated

5
Gene trapped

9
Targeted

8
Genomic Mutations

7 involving Cdca7
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

29 strains or lines available

Homozygosity for the p.G305V mutation reduces global DNA methylation levels and affects expression of various genes and gene clusters.

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All GO Annotations

20
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

734
Tissues

110
cDNA Data

149
Literature Summary

13

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cdca7, cdca7e

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All Sequences

53
RefSeq

11
UniProt

2
CCDS

CCDS16121.1

Ensembl

ENSMUSG00000055612 (Evidence)
NCBI Gene

66953

			Length	Strain/Species	Flank
genomic	66953	NCBI Gene Model \| MGI Sequence Detail	10698	C57BL/6J	± kb
transcript	NM_001418562	RefSeq \| MGI Sequence Detail	2686	C57BL/6
polypeptide	Q9D0M2	UniProt \| EBI \| MGI Sequence Detail	382	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000005224 cell division cycle-associated protein 7

(term hierarchy)
PDB

8TLE, 8TLF, 8TLG, 8TLH, 8TLJ, 8TLL
InterPro Domains

IPR040221 CDCA7/CDA7L

IPR018866 Zinc-finger domain of monoamine-oxidase A repressor R1

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All nucleic 155

cDNA 149

Primer pair 3

Other 3

Antibodies 1

Microarray probesets 3

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MGI:2146580

Summaries

All 70

Developmental Gene Expression 13

Gene Ontology 8

Phenotypes 23
Earliest

J:149 Morelli L, et al., Heterogeneity of natural killer cell subsets in NK-1.1+ and NK-1.1- inbred mouse strains and their progeny. Cell Immunol. 1992 Apr 15;141(1):148-60
Latest

J:373797 Hintermann A, et al., Co-option of an ancestral cloacal regulatory landscape during digit evolution. Nature. 2025 Sep 17;

TSS for Cdca7:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr18351	Chr2:72306340-72306344 (+)	-198 bp
Tssr18352	Chr2:72306517-72306556 (+)	-3 bp
Tssr18353	Chr2:72306557-72306568 (+)	23 bp
Tssr18354	Chr2:72306569-72306603 (+)	46 bp
Tssr522	Chr2:72310376-72310392 (+)	3,844 bp
Tssr523	Chr2:72310423-72310426 (+)	3,885 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/15/2026 MGI 6.29