Trim59 MGI Mouse Gene Detail - MGI:1914199 - tripartite motif-containing 59

Trim59 Gene Detail

Symbol

Trim59
Name

tripartite motif-containing 59
Synonyms

2310035M22Rik, 2700022F13Rik, Mrf1, TSBF1

Feature Type

protein coding gene
IDs

MGI:1914199
NCBI Gene: 66949

Sequence Map

Chr3:69035288-69044755 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

9468 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 32.16 cM, cytoband E2
Mapping Data

3 experiments

Human Ortholog

TRIM59, tripartite motif containing 59

Vertebrate Orthologs

10

Human Ortholog

TRIM59, tripartite motif containing 59
Orthology source: HomoloGene, HGNC
Synonyms

IFT80L, MRF1, RNF104, TRIM57, TSBF1
Links

HGNC:30834

NCBI Gene ID: 286827

neXtProt AC: NX_Q8IWR1

UniProt: Q8IWR1
Chr Location

3q25.33; chr3:160435503-160449838 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 32644
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: TRIM59
Gene Tree

Trim59

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References

1 with disease annotations

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Phenotype Summary

12 phenotype references

All Mutations and Alleles

93
Chemically induced (other)

1
Gene trapped

88
Radiation induced

1
Targeted

3
Genomic Mutations

2 involving Trim59
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

45 strains or lines available

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All GO Annotations

17
GO References

6

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

70
Tissues

52
cDNA Data

119
Literature Summary

5

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase trim59

ZFIN trim59

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Trim59 interacts with 221 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

37
RefSeq

8
UniProt

2
CCDS

CCDS17402.1
UniGene

176695

			Length	Strain/Species	Flank
genomic	OTTMUSG00000024493	VEGA Gene Model \| MGI Sequence Detail	9468	C57BL/6J	± kb
transcript	OTTMUST00000060095	VEGA \| MGI Sequence Detail	2939	Not Applicable
polypeptide	OTTMUSP00000029298	VEGA \| MGI Sequence Detail	403	Not Applicable

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SNPs within 2kb

52 from dbSNP Build 142

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UniProt

2 Sequences
Protein Ontology

PR:000031980 tripartite motif-containing protein 59

(term hierarchy)
InterPro Domains

IPR000315 B-box-type zinc finger

IPR027370 RING-type zinc-finger, LisH dimerisation motif

IPR013083 Zinc finger, RING/FYVE/PHD-type

IPR001841 Zinc finger, RING-type

IPR017907 Zinc finger, RING-type, conserved site

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All nucleic 119

cDNA 119

Microarray probesets 5

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MGI:1919808

Summaries

All 42

Developmental Gene Expression 5

Diseases 1

Gene Ontology 6

Phenotypes 12
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:226028 Lewandowski JP, et al., Spatiotemporal regulation of GLI target genes in the mammalian limb bud. Dev Biol. 2015 Oct 1;406(1):92-103

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 06/13/2017 MGI 6.10