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Trim59 Gene Detail
Summary
  • Symbol
    Trim59
  • Name
    tripartite motif-containing 59
  • Synonyms
    2310035M22Rik, 2700022F13Rik, Mrf1, TSBF1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914199
    NCBI Gene: 66949
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:68942625-68952075 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 32.16 cM, cytoband E2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    285 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914199
 protein coding gene Chr3:68942621-68952088 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027292
 protein coding gene Chr3:68260029-68271162 (-)
A/J MGP_AJ_G0027254
 protein coding gene Chr3:66221025-66233017 (-)
AKR/J MGP_AKRJ_G0027222
 protein coding gene Chr3:67638724-67651525 (-)
BALB/cJ MGP_BALBcJ_G0027265
 protein coding gene Chr3:66099164-66112932 (-)
C3H/HeJ MGP_C3HHeJ_G0027009
 protein coding gene Chr3:67880460-67892837 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027711
 protein coding gene Chr3:70809087-70819286 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025064
 protein coding gene Chr3:62487070-62499270 (-)
CAST/EiJ MGP_CASTEiJ_G0026456
 protein coding gene Chr3:67832751-67845564 (-)
CBA/J MGP_CBAJ_G0026984
 protein coding gene Chr3:72993374-73004800 (-)
DBA/2J MGP_DBA2J_G0027120
 protein coding gene Chr3:65728952-65740380 (-)
FVB/NJ MGP_FVBNJ_G0027088
 protein coding gene Chr3:64350522-64360155 (-)
LP/J MGP_LPJ_G0027228
 protein coding gene Chr3:69193505-69203011 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027107
 protein coding gene Chr3:77605911-77619824 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027769
 protein coding gene Chr3:67530551-67540908 (-)
PWK/PhJ MGP_PWKPhJ_G0026190
 protein coding gene Chr3:65454852-65466927 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026006
 protein coding gene Chr3:66633701-66645118 (-)
WSB/EiJ MGP_WSBEiJ_G0026534
 protein coding gene Chr3:67685208-67695300 (-)



Homology
more
  • Human Ortholog
    TRIM59, tripartite motif containing 59
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TRIM59, tripartite motif containing 59
  • Synonyms
    IFT80L, MRF1, RNF104, TRIM57, TSBF1
  • Links
    NCBI Gene ID: 286827
    UniProt: Q8IWR1

  • Chr Location
    3q25.33; chr3:160432445-160485773 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 2 alleles in 2 genetic backgrounds
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit embryonic lethality associated with failure of primary germ layer formation, small embryonic epiblasts, absent mesoderm, and abnormal inner cell mass differentiation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    821
  • Tissues
    84
  • cDNA Data
    120
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 66949 NCBI Gene Model | MGI Sequence Detail 9451 C57BL/6J ±  kb
    transcript NM_001428934 RefSeq | MGI Sequence Detail 3098 C57BL/6  
    polypeptide Q922Y2 UniProt | EBI | MGI Sequence Detail 403 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 120
      cDNA 120

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1919808
    References
    more
    • Summaries
      All 58
      Developmental Gene Expression 8
      Diseases 1
      Gene Ontology 10
      Phenotypes 20
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:351304 Wang H, et al., TRIM59 deficiency promotes M1 macrophage activation and inhibits colorectal cancer through the STAT1 signaling pathway. Sci Rep. 2024 Jul 12;14(1):16081
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    03/25/2025
    MGI 6.24     		The Jackson Laboratory