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Ddx18 Gene Detail
Summary
  • Symbol
    Ddx18
  • Name
    DEAD (Asp-Glu-Ala-Asp) box polypeptide 18
  • Synonyms
    2310005B10Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914192
    NCBI Gene: 66942
Location & Maps
more
  • Sequence Map
    Chr1:121553835-121567989 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      14155 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 52.98 cM, cytoband E2
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    DDX18, DEAD-box helicase 18
  • Vertebrate Orthologs
    9
  • Human Ortholog
    DDX18, DEAD-box helicase 18
    Orthology source: HomoloGene
  • Synonyms
    MrDb
  • Links
    NCBI Gene ID: 8886
    neXtProt AC: NX_Q9NVP1

  • Chr Location
    2q14.1; chr2:117814679-117832377 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotype references
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    2
  • Gene trapped
    4
  • Radiation induced
    1
  • Genomic Mutations
    3 involving Ddx18
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019928 VEGA Gene Model | MGI Sequence Detail 14155 C57BL/6J ±  kb
transcript OTTMUST00000047501 VEGA | MGI Sequence Detail 2258 Not Applicable  
polypeptide OTTMUSP00000021484 VEGA | MGI Sequence Detail 660 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    171 from dbSNP Build 142
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000006356 ATP-dependent RNA helicase DDX18
  • EC
  • InterPro Domains
    IPR000629 ATP-dependent RNA helicase DEAD-box, conserved site
    IPR011545 DEAD/DEAH box helicase domain
    IPR025313 Domain of unknown function DUF4217
    IPR001650 Helicase, C-terminal
    IPR014001 Helicase superfamily 1/2, ATP-binding domain
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR014014 RNA helicase, DEAD-box type, Q motif
Molecular
Reagents
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  • All nucleic 96
    cDNA 96

    Microarray probesets 6
References
more
  • Summaries
    All 26
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 5
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory