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Cirsr Gene Detail
Summary
  • Symbol
    Cirsr
  • Name
    corepressor of RBPJ and splicing regulator
  • Synonyms
    1700023B02Rik, 2810021A19Rik, CIR, Cir1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914185
    NCBI Gene: 66935
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:73113445-73142922 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 43.54 cM, cytoband C3
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    718 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914185
 protein coding gene Chr2:73113445-73143045 (-)
129S1/SvImJ ENSMUSG00200036076
 protein coding gene Chr2:70182228-70211830 (-)
A/J ENSMUSG00195021114
 protein coding gene Chr2:70328814-70358416 (-)
AKR/J ENSMUSG00220039181
 protein coding gene Chr2:70293422-70323026 (-)
BALB/cJ ENSMUSG00180039820
 protein coding gene Chr2:70282589-70312191 (-)
C3H/HeJ ENSMUSG00175034012
 protein coding gene Chr2:70397544-70427142 (-)
C57BL/6NJ ENSMUSG00215019690
 protein coding gene Chr2:70224811-70254408 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023657
 protein coding gene Chr2:67866486-67896466 (-)
CAST/EiJ ENSTCUG00005008426
 protein coding gene Chr2:69722697-69751843 (-)
CBA/J ENSMUSG00210032601
 protein coding gene Chr2:70440286-70469859 (-)
DBA/2J ENSMUSG00185039617
 protein coding gene Chr2:70276071-70305671 (-)
FVB/NJ ENSMUSG00205020487
 protein coding gene Chr2:69738871-69768470 (-)
JF1/MsJ ENSUMUG00000006160
 protein coding gene Chr2:69936776-69965923 (-)
LP/J ENSMUSG00230021316
 protein coding gene Chr2:72081931-72111534 (-)
NOD/ShiLtJ ENSMUSG00190036100
 protein coding gene Chr2:70361566-70391163 (-)
NZO/HlLtJ ENSMUSG00225014099
 protein coding gene Chr2:79825442-79855039 (-)
PWK/PhJ ENSLUMG00010032267
 protein coding gene Chr2:70174727-70203688 (-)
SPRET/EiJ ENSMSPG00010019375
 protein coding gene Chr2:71587501-71618008 (-)
WSB/EiJ ENSIUOG00005018971
 protein coding gene Chr2:70404463-70434594 (-)



Homology
more
  • Human Ortholog
    CIRSR, corepressor of RBPJ and splicing regulator
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CIRSR, corepressor of RBPJ and splicing regulator
  • Synonyms
    CIR, CIR1, THE1B/CIR1
  • Links
    NCBI Gene ID: 9541
    UniProt: Q86X95

  • Chr Location
    2q31.1; chr2:174348022-174395712 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    32 phenotypes from 1 allele in 1 genetic background
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit a hypocellular placenta, abnormal placental labyrinth vasculature morphology, and complete preweaning lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    34
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    651
  • Tissues
    21
  • cDNA Data
    12
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 66935 NCBI Gene Model | MGI Sequence Detail 29478 C57BL/6J ±  kb
    transcript NM_025854 RefSeq | MGI Sequence Detail 2702 C57BL/6  
    polypeptide Q9DA19 UniProt | EBI | MGI Sequence Detail 450 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000005498 corepressor of RBPJ and splicing regulator
      (term hierarchy)
    • InterPro Domains
      IPR019339 CBF1-interacting co-repressor CIR, N-terminal domain
      IPR040014 Corepressor interacting with RBPJ 1
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 12

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1922067, MGI:8328342
    References
    more
    • Summaries
      All 62
      Developmental Gene Expression 4
      Gene Ontology 11
      Phenotypes 28
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:373797 Hintermann A, et al., Co-option of an ancestral cloacal regulatory landscape during digit evolution. Nature. 2025 Sep 17;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    09/01/2026
    MGI 6.24     		The Jackson Laboratory