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Rras2
Gene Detail
Symbol

Name
ID
Rras2
related RAS viral (r-ras) oncogene homolog 2
MGI:1914172
Synonyms
2610016H24Rik, TC21
Feature Type
protein coding gene
Genetic Map
Chromosome 7
59.29 cM, cytoband F2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr7:114046785-114117781 bp, - strand
From Ensembl annotation of GRCm38

  70997 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:6945  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: ras protein
Gene Tree: Rras2

Human
homologs
Human Homolog RRAS2, related RAS viral (r-ras) oncogene homolog 2
NCBI Gene ID 22800
neXtProt AC  NX_P62070
Human Synonyms  TC21
Human Chr (Location)  11p15.2; chr11:14277920-14364506 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(35) : Gene trapped(32) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygote and heterozygote null mice are lymphopenic, resulting from diminished homeostatic proliferation and impaired T cell and B cell survival. Mice homozygous for a gene trap insertion exhibit retinal degeneration, and increased total body mass and total body fat.
 
Interactions
Rras2 interacts with 310 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process cellular process, GTP catabolic process, ...
Component extracellular vesicular exosome, focal adhesion, ...
Function GTP binding, nucleotide binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (17)    Tissues (13)    Images (5)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 7
RNA in situ 5
Western blot 5
cDNA source data(70)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(70) cDNA(70)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000055723 (Evidence)
Entrez Gene66922 (Evidence)
UniGene276572
DFCITC1577712
DoTSDT.530836, DT.94135473
NIA Mouse Gene IndexU029145
Consensus CDS ProjectCCDS21758.1
International Mouse Knockout Project StatusRras2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000055723 Ensembl Gene Model | MGI Sequence Detail 70997 C57BL/6J ±  kb
transcript ENSMUST00000069449 Ensembl | MGI Sequence Detail 2272 Not Applicable 
polypeptide ENSMUSP00000069752 Ensembl | MGI Sequence Detail 204 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(4) UniProt(2)
Polymorphisms
SNPs within 2kb(589 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR001806 Small GTPase superfamily
InterPro IPR020849 Small GTPase superfamily, Ras type
InterPro IPR005225 Small GTP-binding protein domain
Protein Ontology PR:000014302 ras-related protein R-Ras2
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:198767 Iwasawa N, et al., R-Ras controls axon branching through afadin in cortical neurons. Mol Biol Cell. 2012 Jul;23(14):2793-804
All references(48)
Other
accession IDs
MGI:2142366

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory