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Plin3 Gene Detail
Summary
  • Symbol
    Plin3
  • Name
    perilipin 3
  • Synonyms
    1300012C15Rik, M6prbp1, Tip47
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914155
    NCBI Gene: 66905
  • Gene Overview
    MyGene.info: PLIN3
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:56278962-56290511 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 29.25 cM, cytoband D
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914155
protein coding gene Chr17:56278962-56290511 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023922
protein coding gene Chr17:57957714-57972913 (-)
A/J MGP_AJ_G0023880
protein coding gene Chr17:56376121-56388794 (-)
AKR/J MGP_AKRJ_G0023849
protein coding gene Chr17:57062308-57078332 (-)
BALB/cJ MGP_BALBcJ_G0023881
protein coding gene Chr17:56199428-56211571 (-)
C3H/HeJ MGP_C3HHeJ_G0023645
protein coding gene Chr17:57777118-57789423 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024327
protein coding gene Chr17:60227039-60238464 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021773
protein coding gene Chr17:52865835-52877594 (-)
CAST/EiJ MGP_CASTEiJ_G0023127
protein coding gene Chr17:58078210-58091345 (-)
CBA/J MGP_CBAJ_G0023621
protein coding gene Chr17:62556654-62571048 (-)
DBA/2J MGP_DBA2J_G0023749
protein coding gene Chr17:55086833-55098619 (-)
FVB/NJ MGP_FVBNJ_G0023715
protein coding gene Chr17:54617775-54629548 (-)
LP/J MGP_LPJ_G0023831
protein coding gene Chr17:58644600-58656563 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023743
protein coding gene Chr17:62069535-62084503 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024371
protein coding gene Chr17:57434168-57446650 (-)
PWK/PhJ MGP_PWKPhJ_G0022873
protein coding gene Chr17:54436804-54448141 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022684
protein coding gene Chr17:54191821-54204059 (-)
WSB/EiJ MGP_WSBEiJ_G0023193
protein coding gene Chr17:58037320-58051797 (-)



Homology
more
  • Human Ortholog
    PLIN3, perilipin 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PLIN3, perilipin 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    M6PRBP1, PP17, TIP47
  • Links
    NCBI Gene ID: 10226
    neXtProt AC: NX_O60664
    UniProt: O60664

  • Chr Location
    19p13.3; chr19:4838334-4867768 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display enhanced cold tolerance and increased beige adipocyte formation and thermogenic activity.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 66905 NCBI Gene Model | MGI Sequence Detail 11550 C57BL/6J ±  kb
    transcript NM_025836 RefSeq | MGI Sequence Detail 2159 C57BL/6  
    polypeptide Q9DBG5 UniProt | EBI | MGI Sequence Detail 437 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 116
      cDNA 116

      Microarray probesets 2
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 5
      Gene Ontology 3
      Phenotypes 9
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:261132 Lee YK, et al., Perilipin 3 Deficiency Stimulates Thermogenic Beige Adipocytes Through PPARalpha Activation. Diabetes. 2018 May;67(5):791-804

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory