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Mtap Gene Detail
Summary
  • Symbol
    Mtap
  • Name
    methylthioadenosine phosphorylase
  • Synonyms
    1300019I21Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914152
    NCBI Gene: 66902
  • Gene Overview
    MyGene.info: MTAP
Location & Maps
more
  • Sequence Map
    Chr4:89137122-89181081 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      43960 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 42.15 cM, cytoband C4
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    MTAP, methylthioadenosine phosphorylase
  • Vertebrate Orthologs
    9
  • Human Ortholog
    MTAP, methylthioadenosine phosphorylase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BDMF, c86fus, DMSFH, DMSMFH, HEL-249, LGMBF, MSAP
  • Links
    NCBI Gene ID: 4507
    neXtProt AC: NX_Q13126

  • Chr Location
    9p21.3; chr9:21802636-21865971 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 1838
    1 human;1 mouse;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: MTAP
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Chemically induced (other)
    2
  • Gene trapped
    6
  • Radiation induced
    1
  • Targeted
    1
  • Genomic Mutations
    3 involving Mtap
  • Incidental Mutations
Mice homozygous for a gene trapped allele die by E8.5. Heterozygotes display no significant hearing loss up to 6 months of age.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000007694 VEGA Gene Model | MGI Sequence Detail 43960 C57BL/6J ±  kb
transcript OTTMUST00000017624 VEGA | MGI Sequence Detail 2797 Not Applicable  
polypeptide OTTMUSP00000008137 VEGA | MGI Sequence Detail 283 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    165 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 104
    cDNA 104

    Microarray probesets 6
References
more
  • Summaries
    All 37
    Developmental Gene Expression 4
    Gene Ontology 5
    Phenotypes 12
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:203713 Kadariya Y, et al., Germline Mutations in Cooperate with to Accelerate Tumorigenesis in Mice. PLoS One. 2013;8(6):e67635

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory