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Mtap
Gene Detail
Symbol

Name
ID
Mtap
methylthioadenosine phosphorylase
MGI:1914152
Synonyms
1300019I21Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 4
42.15 cM, cytoband C4
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr4:89137122-89181081 bp, + strand
From VEGA annotation of GRCm38

  43960 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1838  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: MTAP
Gene Tree: Mtap

Human
homologs
MTAP, methylthioadenosine phosphorylase
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 4507
neXtProt AC: NX_Q13126

Human Synonyms: BDMF, c86fus, DMSFH, DMSMFH, HEL-249, LGMBF, MSAP

Human Chr (Location): 9p21; chr9:21802636-21865971 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(6) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a gene trapped allele die by E8.5. Heterozygotes display no significant hearing loss up to 6 months of age.
 
Interactions
Mtap interacts with 195 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process methylation, nucleoside metabolic process, ...
Component cytoplasm, extracellular exosome, ...
Function catalytic activity, phosphorylase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (271)    Tissues (142)    Images (41)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 271
cDNA source data(103)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase mtap ; ZFIN mtap    NEW 
Molecular
reagents
All nucleic(104) cDNA(104)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000007694 (Evidence)
Ensembl Gene Model ENSMUSG00000062937 (Evidence)
Entrez Gene 66902 (Evidence)
UniGene 28500
DFCI TC1575102
DoTS DT.529888
NIA Mouse Gene Index U004487
EC 2.4.2.28
Consensus CDS Project CCDS18349.1
International Mouse Phenotyping Consortium Status Mtap
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000007694 VEGA Gene Model | MGI Sequence Detail 43960 C57BL/6J ±  kb
transcript OTTMUST00000017624 VEGA | MGI Sequence Detail 2797 Not Applicable 
polypeptide OTTMUSP00000008137 VEGA | MGI Sequence Detail 283 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(166 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR010044 Methylthioadenosine phosphorylase (MTAP)
InterPro IPR000845 Nucleoside phosphorylase domain
InterPro IPR001369 PNP/MTAP phosphorylase
InterPro IPR018099 Purine phosphorylase, family 2, conserved site
Protein Ontology PR:000010710 S-methyl-5'-thioadenosine phosphorylase
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:203713 Kadariya Y, et al., Germline Mutations in Cooperate with to Accelerate Tumorigenesis in Mice. PLoS One. 2013;8(6):e67635
All references(40)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory