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Mtap Gene Detail
Summary
  • Symbol
    Mtap
  • Name
    methylthioadenosine phosphorylase
  • Synonyms
    1300019I21Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914152
    NCBI Gene: 66902
  • Gene Overview
    MyGene.info: MTAP
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:89137370-89181090 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 42.15 cM, cytoband C4
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    163 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914152
protein coding gene Chr4:89137122-89181090 (.)
129S1/SvImJ MGP_129S1SvImJ_G0028440
protein coding gene Chr4:89074897-89136176 (+)
A/J MGP_AJ_G0028402
protein coding gene Chr4:85948355-85993918 (+)
AKR/J MGP_AKRJ_G0028350
protein coding gene Chr4:88074124-88126461 (+)
BALB/cJ MGP_BALBcJ_G0028421
protein coding gene Chr4:86180963-86226733 (+)
C3H/HeJ MGP_C3HHeJ_G0028133
protein coding gene Chr4:88821604-88871991 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028860
protein coding gene Chr4:92455634-92505076 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026155
protein coding gene Chr4:81894817-81937625 (+)
CAST/EiJ MGP_CASTEiJ_G0027574
protein coding gene Chr4:86658769-86709690 (+)
CBA/J MGP_CBAJ_G0028103
protein coding gene Chr4:95320726-95378693 (+)
DBA/2J MGP_DBA2J_G0028253
protein coding gene Chr4:85703908-85748254 (+)
FVB/NJ MGP_FVBNJ_G0028220
protein coding gene Chr4:84639359-84683781 (+)
LP/J MGP_LPJ_G0028353
protein coding gene Chr4:89362203-89411678 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028249
protein coding gene Chr4:100309104-100356046 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028898
protein coding gene Chr4:88226179-88277595 (+)
PWK/PhJ MGP_PWKPhJ_G0027298
protein coding gene Chr4:83995960-84045286 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027119
protein coding gene Chr4:85757767-85804766 (+)
WSB/EiJ MGP_WSBEiJ_G0027652
protein coding gene Chr4:88439045-88487087 (+)



Homology
more
  • Human Ortholog
    MTAP, methylthioadenosine phosphorylase
  • Vertebrate Orthologs
    9
  • Human Ortholog
    MTAP, methylthioadenosine phosphorylase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BDMF, c86fus, DMSFH, DMSMFH, HEL-249, LGMBF, MSAP
  • Links
    NCBI Gene ID: 4507
    neXtProt AC: NX_Q13126
    UniProt: Q13126

  • Chr Location
    9p21.3; chr9:21802636-21865971 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 1838
    1 human;1 mouse;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: MTAP
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trapped allele die by E8.5. Heterozygotes display no significant hearing loss up to 6 months of age.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 66902 NCBI Gene Model | MGI Sequence Detail 43721 C57BL/6J ±  kb
    transcript NM_024433 RefSeq | MGI Sequence Detail 2558 C57BL/6  
    polypeptide Q9CQ65 UniProt | EBI | MGI Sequence Detail 283 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 105
      cDNA 105

      Microarray probesets 6
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 4
      Gene Ontology 6
      Phenotypes 12
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:203713 Kadariya Y, et al., Germline Mutations in Cooperate with to Accelerate Tumorigenesis in Mice. PLoS One. 2013;8(6):e67635

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.
    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory