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Serbp1 Gene Detail
Summary
  • Symbol
    Serbp1
  • Name
    serpine1 mRNA binding protein 1
  • Synonyms
    1200009K13Rik, 9330147J08Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914120
    NCBI Gene: 66870
  • Gene Overview
    MyGene.info: SERBP1
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:67266979-67289302 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 30.80 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    137 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914120
 protein coding gene Chr6:67238176-67297736 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030844
 protein coding gene Chr6:67221632-67285319 (+)
A/J MGP_AJ_G0030814
 protein coding gene Chr6:64318589-64385104 (+)
AKR/J MGP_AKRJ_G0030742
 protein coding gene Chr6:66344656-66405149 (+)
BALB/cJ MGP_BALBcJ_G0030825
 protein coding gene Chr6:64698422-64759486 (+)
C3H/HeJ MGP_C3HHeJ_G0030887
 protein coding gene Chr6:117735844-117796926 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031283
 protein coding gene Chr6:68833692-68893963 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028472
 protein coding gene Chr6:61492131-61553384 (+)
CAST/EiJ MGP_CASTEiJ_G0029933
 protein coding gene Chr6:66628965-66693157 (+)
CBA/J MGP_CBAJ_G0030512
 protein coding gene Chr6:71640435-71706299 (+)
DBA/2J MGP_DBA2J_G0030664
 protein coding gene Chr6:63988764-64048780 (+)
FVB/NJ MGP_FVBNJ_G0030617
 protein coding gene Chr6:63492755-63553070 (+)
LP/J MGP_LPJ_G0030743
 protein coding gene Chr6:67182460-67251872 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030652
 protein coding gene Chr6:75365146-75446247 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031309
 protein coding gene Chr6:66254971-66319680 (+)
PWK/PhJ MGP_PWKPhJ_G0029648
 protein coding gene Chr6:63181877-63242978 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029477
 protein coding gene Chr6:65830174-65893870 (+)
WSB/EiJ MGP_WSBEiJ_G0030015
 protein coding gene Chr6:66590119-66655151 (+)



Homology
more
  • Human Ortholog
    SERBP1, SERPINE1 mRNA binding protein 1
  • Vertebrate Orthologs
    3
  • Human Ortholog
    SERBP1, SERPINE1 mRNA binding protein 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CGI-55, CHD3IP, HABP4L, PAIRBP1, PAI-RBP1
  • Links
    NCBI Gene ID: 26135
    neXtProt AC: NX_Q8NC51
    UniProt: Q8NC51

  • Chr Location
    1p31.3; chr1:67407810-67430440 (-)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    9
  • Tissues
    4
  • cDNA Data
    27
  • Literature Summary
    2
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 66870 NCBI Gene Model | MGI Sequence Detail 22324 C57BL/6J ±  kb
transcript NM_025814 RefSeq | MGI Sequence Detail 6685 C57BL/6  
polypeptide Q9CY58 UniProt | EBI | MGI Sequence Detail 407 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    11 Sequences
  • Protein Ontology
    PR:000014665 plasminogen activator inhibitor 1 RNA-binding protein
    (term hierarchy)
  • InterPro Domains
    IPR006861 Hyaluronan/mRNA-binding protein
    IPR032381 Intracellular hyaluronan-binding protein 4, N-terminal domain
    IPR027205 Plasminogen activator inhibitor 1 RNA-binding protein
    IPR039764 RNA binding protein HABP4/SERBP1
Molecular
Reagents
less
  • All nucleic 28
    cDNA 27
    Primer pair 1

    Microarray probesets 7
Other
Accession IDs
less
MGI:2141530, MGI:2444088
References
more
  • Summaries
    All 34
    Developmental Gene Expression 2
    Gene Ontology 3
    Phenotypes 7
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:241613 Guo X, et al., VCP recruitment to mitochondria causes mitophagy impairment and neurodegeneration in models of Huntington's disease. Nat Commun. 2016 Aug 26;7:12646
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
10/15/2019
MGI 6.14 		The Jackson Laboratory