Serbp1 MGI Mouse Gene Detail - MGI:1914120 - serpine1 mRNA binding protein 1

Symbol

Serbp1
Name

serpine1 mRNA binding protein 1
Synonyms

1200009K13Rik, 9330147J08Rik

Feature Type

protein coding gene
IDs

MGI:1914120
NCBI Gene: 66870
Alliance

gene page
Transcription Start Sites

15 TSS

Sequence Map

Chr6:67243963-67266286 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 30.80 cM
Mapping Data

2 experiments

SNPs within 2kb

627 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914120	protein coding gene	Chr6:67215160-67274720 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0030844	protein coding gene	Chr6:67221632-67285319 (+)
A/J	MGP_AJ_G0030814	protein coding gene	Chr6:64318589-64385104 (+)
AKR/J	MGP_AKRJ_G0030742	protein coding gene	Chr6:66344656-66405149 (+)
BALB/cJ	MGP_BALBcJ_G0030825	protein coding gene	Chr6:64698422-64759486 (+)
C3H/HeJ	MGP_C3HHeJ_G0030887	protein coding gene	Chr6:117735844-117796926 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0031283	protein coding gene	Chr6:68833692-68893963 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028472	protein coding gene	Chr6:61492131-61553384 (+)
CAST/EiJ	MGP_CASTEiJ_G0029933	protein coding gene	Chr6:66628965-66693157 (+)
CBA/J	MGP_CBAJ_G0030512	protein coding gene	Chr6:71640435-71706299 (+)
DBA/2J	MGP_DBA2J_G0030664	protein coding gene	Chr6:63988764-64048780 (+)
FVB/NJ	MGP_FVBNJ_G0030617	protein coding gene	Chr6:63492755-63553070 (+)
LP/J	MGP_LPJ_G0030743	protein coding gene	Chr6:67182460-67251872 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030652	protein coding gene	Chr6:75365146-75446247 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031309	protein coding gene	Chr6:66254971-66319680 (+)
PWK/PhJ	MGP_PWKPhJ_G0029648	protein coding gene	Chr6:63181877-63242978 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0029477	protein coding gene	Chr6:65830174-65893870 (+)
WSB/EiJ	MGP_WSBEiJ_G0030015	protein coding gene	Chr6:66590119-66655151 (+)

Human Ortholog

SERBP1, SERPINE1 mRNA binding protein 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SERBP1, SERPINE1 mRNA binding protein 1
Synonyms

CGI-55, CHD3IP, HABP4L, Hero45, PAI-RBP1, PAIRBP1
Links

HGNC:17860

NCBI Gene ID: 26135

UniProt: Q8NC51
Chr Location

1p31.3; chr1:67407810-67430415 (-) GRCh38

MGI Vertebrate Homology

Serbp1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: SERBP1
Gene Tree

Serbp1

less

Phenotype Summary

8 phenotype references

All Mutations and Alleles

83
Endonuclease-mediated

2
Gene trapped

79
Targeted

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

33 strains or lines available

less

All GO Annotations

46
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

719
Tissues

7
cDNA Data

28
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase serbp1

ZFIN serbp1a

less

All Sequences

103
RefSeq

8
UniProt

11
CCDS

CCDS20219.1, CCDS85060.1, CCDS85061.1, CCDS85062.1

Ensembl

ENSMUSG00000036371 (Evidence)
NCBI Gene

66870

			Length	Strain/Species	Flank
genomic	66870	NCBI Gene Model \| MGI Sequence Detail	22324	C57BL/6J	± kb
transcript	NM_025814	RefSeq \| MGI Sequence Detail	6685	C57BL/6
polypeptide	Q9CY58	UniProt \| EBI \| MGI Sequence Detail	407	Not Applicable

less

UniProt

11 Sequences
Protein Ontology

PR:000014665 SERPINE1 mRNA-binding protein 1

(term hierarchy)
PDB

7LS1, 7LS2
InterPro Domains

IPR006861 Hyaluronan/mRNA-binding protein

IPR032381 Intracellular hyaluronan-binding protein 4, N-terminal domain

IPR039764 RNA binding protein HABP4/SERBP1-like
GlyGen

Q9CY58 1 site, 1 O-linked glycan (1 site)

less

All nucleic 29

cDNA 28

Primer pair 1

Microarray probesets 7

less

MGI:2141530, MGI:2444088

Summaries

All 42

Developmental Gene Expression 3

Gene Ontology 9

Phenotypes 8
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Serbp1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr56889	Chr6:67243971-67244005 (+)	25 bp
Tssr56890	Chr6:67247423-67247427 (+)	3,462 bp
Tssr56891	Chr6:67248177-67248214 (+)	4,233 bp
Tssr56892	Chr6:67248241-67248262 (+)	4,289 bp
Tssr56893	Chr6:67248892-67248904 (+)	4,935 bp
Tssr56894	Chr6:67248911-67248940 (+)	4,963 bp
Tssr56895	Chr6:67248941-67248966 (+)	4,991 bp
Tssr56896	Chr6:67249143-67249180 (+)	5,199 bp
Tssr56897	Chr6:67249872-67249897 (+)	5,922 bp
Tssr56898	Chr6:67254742-67254791 (+)	10,804 bp
Tssr56899	Chr6:67254796-67254817 (+)	10,844 bp
Tssr56900	Chr6:67255201-67255204 (+)	11,240 bp
Tssr56901	Chr6:67259071-67259075 (+)	15,110 bp
Tssr56902	Chr6:67260917-67260965 (+)	16,978 bp
Tssr56903	Chr6:67262315-67262319 (+)	18,354 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/18/2025 MGI 6.24