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Clec14a Gene Detail
Summary
  • Symbol
    Clec14a
  • Name
    C-type lectin domain family 14, member a
  • Synonyms
    1200003C23Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914114
    NCBI Gene: 66864
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:58264720-58269258 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 25.65 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    58 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914114
protein coding gene Chr12:58264720-58269290 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019764
protein coding gene Chr12:57458609-57463147 (-)
A/J MGP_AJ_G0019723
protein coding gene Chr12:55346737-55351278 (-)
AKR/J MGP_AKRJ_G0019698
protein coding gene Chr12:57114865-57119403 (-)
BALB/cJ MGP_BALBcJ_G0019703
protein coding gene Chr12:55712629-55717170 (-)
C3H/HeJ MGP_C3HHeJ_G0019508
protein coding gene Chr12:57187651-57192192 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020155
protein coding gene Chr12:59160830-59165368 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017775
protein coding gene Chr12:53760508-53765055 (-)
CAST/EiJ MGP_CASTEiJ_G0019060
protein coding gene Chr12:52110563-52115104 (-)
CBA/J MGP_CBAJ_G0019477
protein coding gene Chr12:61269434-61273975 (-)
DBA/2J MGP_DBA2J_G0019593
protein coding gene Chr12:55257874-55262415 (-)
FVB/NJ MGP_FVBNJ_G0019581
protein coding gene Chr12:54532087-54536628 (-)
LP/J MGP_LPJ_G0019665
protein coding gene Chr12:57448452-57452990 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019619
protein coding gene Chr12:62881429-62886755 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020189
protein coding gene Chr12:56559013-56563551 (-)
PWK/PhJ MGP_PWKPhJ_G0018827
protein coding gene Chr12:49648989-49653531 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018620
protein coding gene Chr12:50968856-50973359 (-)
WSB/EiJ MGP_WSBEiJ_G0019111
protein coding gene Chr12:57120685-57125223 (-)



Homology
more
  • Human Ortholog
    CLEC14A, C-type lectin domain containing 14A
  • Vertebrate Orthologs
    7
  • Human Ortholog
    CLEC14A, C-type lectin domain containing 14A
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C14orf27, CEG1, EGFR-5
  • Links
    NCBI Gene ID: 161198
    neXtProt AC: NX_Q86T13
    UniProt: Q86T13

  • Chr Location
    14q21.1; chr14:38254000-38256370 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    8 phenotype references
No notable pheontype was detected in a high-throughput screen of homozygous mutant mice.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 66864 NCBI Gene Model | MGI Sequence Detail 4539 C57BL/6J ±  kb
transcript NM_025809 RefSeq | MGI Sequence Detail 4539 C57BL/6  
polypeptide Q8VCP9 UniProt | EBI | MGI Sequence Detail 459 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 35
    cDNA 35

    Microarray probesets 4
Other
Accession IDs
less
MGI:2144870
References
more
  • Summaries
    All 33
    Developmental Gene Expression 3
    Gene Ontology 4
    Phenotypes 8
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:239835 Lee S, et al., Carbohydrate-binding protein CLEC14A regulates VEGFR-2- and VEGFR-3-dependent signals during angiogenesis and lymphangiogenesis. J Clin Invest. 2017 Feb 01;127(2):457-471

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
08/06/2019
MGI 6.14
The Jackson Laboratory