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Tanc1
Gene Detail
 Symbol
Name
ID
Tanc1
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1
MGI:1914110
Synonyms 1200003E16Rik, mKIAA1728
Feature Type protein coding gene
Genetic Map
Chromosome 2
33.93 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:59612042-59845717 bp, + strand
From VEGA annotation of GRCm38

  233676 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:18946  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Tanc1

Human
homologs
Human Homolog TANC1, tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1
NCBI Gene ID 85461
neXtProt AC  NX_Q9C0D5
Human Synonyms  ROLSB, TANC
Human Chr (Location)  2q24.2; chr2:158968634-159232659 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(776) : Gene trapped(776)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a gene trap vector exhibit decreased spine density in the CA3 region and impaired spatial memory.
 
Interactions
Tanc1 interacts with 313 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process dendritic spine maintenance, myoblast fusion, ...
Component axon terminus, cell junction, ...
Function molecular_function
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (44)    Tissues (5)    Images (19)
Theiler Stages: 23
Assay TypeResults
RNA in situ 44
cDNA source data(16)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(16) cDNA(16)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000012709 (Evidence)
Ensembl Gene ModelENSMUSG00000035168 (Evidence)
Entrez Gene66860 (Evidence)
DFCITC1575754, TC1595239
DoTSDT.101389557, DT.101389559, DT.101724509, DT.530845, DT.94201598
NIA Mouse Gene IndexU001802
Consensus CDS ProjectCCDS16054.1, CCDS71057.1
International Mouse Knockout Project StatusTanc1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012709 VEGA Gene Model | MGI Sequence Detail 233676 C57BL/6J ±  kb
transcript OTTMUST00000089438 VEGA | MGI Sequence Detail 7246 Not Applicable 
polypeptide OTTMUSP00000048878 VEGA | MGI Sequence Detail 1856 Not Applicable 

For the selected sequences
All sequences(81) RefSeq(18) UniProt(5)
Polymorphisms SNPs within 2kb(1838 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002110 Ankyrin repeat
InterPro IPR020683 Ankyrin repeat-containing domain
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR011990 Tetratricopeptide-like helical
InterPro IPR019734 Tetratricopeptide repeat
InterPro IPR013026 Tetratricopeptide repeat-containing domain
InterPro IPR013105 Tetratricopeptide TPR2
Protein Ontology PR:000016046 protein TANC1
References (Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:184397 Avirneni-Vadlamudi U, et al., Drosophila and mammalian models uncover a role for the myoblast fusion gene TANC1 in rhabdomyosarcoma. J Clin Invest. 2012 Jan 3;122(1):403-7
All references(38)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory