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Tanc1
Gene Detail
Symbol

Name
ID
Tanc1
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1
MGI:1914110
Synonyms
1200003E16Rik, mKIAA1728
Feature Type
protein coding gene
Genetic Map
Chromosome 2
33.93 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:59612042-59845717 bp, + strand
From VEGA annotation of GRCm38

  233676 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:18946  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: TANC1
Gene Tree: Tanc1

Human
homologs
TANC1, tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 85461
neXtProt AC: NX_Q9C0D5

Human Synonyms: ROLSB, TANC

Human Chr (Location): 2q24.2; chr2:158968634-159232663 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(776) : Gene trapped(776)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a gene trap vector exhibit decreased spine density in the CA3 region and impaired spatial memory.
 
Interactions
Tanc1 interacts with 312 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process dendritic spine maintenance, myoblast fusion, ...
Component axon terminus, cell junction, ...
Function molecular_function
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (44)    Tissues (5)    Images (19)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 44
cDNA source data(17)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase tanc1    NEW 
Molecular
reagents
All nucleic(17) cDNA(17)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000012709 (Evidence)
Ensembl Gene Model ENSMUSG00000035168 (Evidence)
Entrez Gene 66860 (Evidence)
DFCI TC1575754, TC1595239
DoTS DT.101389557, DT.101389559, DT.530845, DT.101724509, DT.94201598
NIA Mouse Gene Index U001802
Consensus CDS Project CCDS16054.1, CCDS71057.1
International Mouse Phenotyping Consortium Status Tanc1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012709 VEGA Gene Model | MGI Sequence Detail 233676 C57BL/6J ±  kb
transcript OTTMUST00000089438 VEGA | MGI Sequence Detail 7246 Not Applicable 
polypeptide OTTMUSP00000048878 VEGA | MGI Sequence Detail 1856 Not Applicable 

For the selected sequences
All sequences(83) RefSeq(18) UniProt(6)
Polymorphisms
SNPs within 2kb(1838 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002110 Ankyrin repeat
InterPro IPR020683 Ankyrin repeat-containing domain
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR011990 Tetratricopeptide-like helical
InterPro IPR019734 Tetratricopeptide repeat
InterPro IPR013026 Tetratricopeptide repeat-containing domain
InterPro IPR013105 Tetratricopeptide TPR2
Protein Ontology PR:000016046 protein TANC1
References
(Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:184397 Avirneni-Vadlamudi U, et al., Drosophila and mammalian models uncover a role for the myoblast fusion gene TANC1 in rhabdomyosarcoma. J Clin Invest. 2012 Jan 3;122(1):403-7
All references(36)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory