About   Help   FAQ
Tanc1 Gene Detail
Summary
  • Symbol
    Tanc1
  • Name
    tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1
  • Synonyms
    1200003E16Rik, mKIAA1728
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914110
    NCBI Gene: 66860
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:59612042-59846149 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 33.93 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1835 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914110
protein coding gene Chr2:59598965-59846213 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025756
protein coding gene Chr2:59155126-59402784 (+)
A/J MGP_AJ_G0025732
protein coding gene Chr2:56870158-57108396 (+)
AKR/J MGP_AKRJ_G0025702
protein coding gene Chr2:58434848-58677625 (+)
BALB/cJ MGP_BALBcJ_G0025727
protein coding gene Chr2:56980816-57217040 (+)
C3H/HeJ MGP_C3HHeJ_G0025488
protein coding gene Chr2:58541965-58784285 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026174
protein coding gene Chr2:60922763-61169087 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023578
protein coding gene Chr2:54466243-54703486 (+)
CAST/EiJ MGP_CASTEiJ_G0024952
protein coding gene Chr2:58572252-58820062 (+)
CBA/J MGP_CBAJ_G0025468
protein coding gene Chr2:63224032-63481115 (+)
DBA/2J MGP_DBA2J_G0025599
protein coding gene Chr2:56488663-56725144 (+)
FVB/NJ MGP_FVBNJ_G0025561
protein coding gene Chr2:56028641-56267794 (+)
LP/J MGP_LPJ_G0025687
protein coding gene Chr2:59012732-59254281 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025592
protein coding gene Chr2:64857570-65105391 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026231
protein coding gene Chr2:58466613-58704771 (+)
PWK/PhJ MGP_PWKPhJ_G0024693
protein coding gene Chr2:56325256-56566355 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024500
protein coding gene Chr2:58550870-58789423 (+)
WSB/EiJ MGP_WSBEiJ_G0025020
protein coding gene Chr2:58763969-59004898 (+)



Homology
more
  • Human Ortholog
    TANC1, tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TANC1, tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1
    Orthology source: HomoloGene
  • Synonyms
    ROLSB, TANC
  • Links
    NCBI Gene ID: 85461
    neXtProt AC: NX_Q9C0D5
    UniProt: Q9C0D5

  • Chr Location
    2q24.2; chr2:158968600-159232659 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 18946
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: TANC1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap vector exhibit decreased spine density in the CA3 region and impaired spatial memory.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000035168 Ensembl Gene Model | MGI Sequence Detail 234108 C57BL/6J ±  kb
    transcript ENSMUST00000139863 Ensembl | MGI Sequence Detail 7246 Not Applicable  
    polypeptide ENSMUSP00000123345 Ensembl | MGI Sequence Detail 1856 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 18

      Microarray probesets 3
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 1
      Gene Ontology 4
      Phenotypes 14
    • Earliest
      J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
    • Latest
      J:184397 Avirneni-Vadlamudi U, et al., Drosophila and mammalian models uncover a role for the myoblast fusion gene TANC1 in rhabdomyosarcoma. J Clin Invest. 2012 Jan 3;122(1):403-7

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    03/13/2019
    MGI 6.13
    The Jackson Laboratory