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Tanc1 Gene Detail
Summary
  • Symbol
    Tanc1
  • Name
    tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1
  • Synonyms
    1200003E16Rik, mKIAA1728
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914110
    NCBI Gene: 66860
Location & Maps
more
  • Sequence Map
    Chr2:59612042-59845717 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      233676 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 33.93 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    TANC1, tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TANC1, tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1
    Orthology source: HomoloGene
  • Synonyms
    ROLSB, TANC
  • Links
    NCBI Gene ID: 85461
    neXtProt AC: NX_Q9C0D5

  • Chr Location
    2q24.2; chr2:158968634-159232663 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 18946
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: TANC1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    777
  • Chemically induced (other)
    1
  • Gene trapped
    776
  • Genomic Mutations
    1 involving Tanc1
  • Incidental Mutations
Mice homozygous for a gene trap vector exhibit decreased spine density in the CA3 region and impaired spatial memory.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012709 VEGA Gene Model | MGI Sequence Detail 233676 C57BL/6J ±  kb
transcript OTTMUST00000089438 VEGA | MGI Sequence Detail 7246 Not Applicable  
polypeptide OTTMUSP00000048878 VEGA | MGI Sequence Detail 1856 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1835 from dbSNP Build 142
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000016046 protein TANC1
  • InterPro Domains
    IPR002110 Ankyrin repeat
    IPR020683 Ankyrin repeat-containing domain
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR011990 Tetratricopeptide-like helical domain
    IPR019734 Tetratricopeptide repeat
    IPR013026 Tetratricopeptide repeat-containing domain
Molecular
Reagents
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  • All nucleic 17
    cDNA 17

    Microarray probesets 3
References
more
  • Summaries
    All 33
    Developmental Gene Expression 1
    Gene Ontology 3
    Phenotypes 12
  • Earliest
    J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
  • Latest
    J:184397 Avirneni-Vadlamudi U, et al., Drosophila and mammalian models uncover a role for the myoblast fusion gene TANC1 in rhabdomyosarcoma. J Clin Invest. 2012 Jan 3;122(1):403-7

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory