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Tcf25 Gene Detail
Summary
  • Symbol
    Tcf25
  • Name
    transcription factor 25 (basic helix-loop-helix)
  • Synonyms
    1100001J13Rik, 1810041K11Rik, D8Ertd325e, mKIAA1049, Nulp1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914105
    NCBI Gene: 66855
  • Alliance
    genome feature page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:124100492-124130574 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 72.10 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1071 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914105
 protein coding gene Chr8:124097511-124130913 (+)
129S1/SvImJ ENSMUSG00200042181
 protein coding gene Chr8:118428976-118459283 (+)
A/J ENSMUSG00195025310
 protein coding gene Chr8:118722542-118752626 (+)
AKR/J ENSMUSG00220039308
 protein coding gene Chr8:118918054-118948306 (+)
BALB/cJ ENSMUSG00180023704
 protein coding gene Chr8:118768524-118798609 (+)
C3H/HeJ ENSMUSG00175028260
 protein coding gene Chr8:118829965-118860216 (+)
C57BL/6NJ ENSMUSG00215028163
 protein coding gene Chr8:118406796-118436879 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031688
 protein coding gene Chr8:114544734-114577045 (+)
CAST/EiJ ENSTCUG00005034284
 protein coding gene Chr8:118145455-118176419 (+)
CBA/J ENSMUSG00210032647
 protein coding gene Chr8:118757065-118787367 (+)
DBA/2J ENSMUSG00185034237
 protein coding gene Chr8:124862002-124892304 (+)
FVB/NJ ENSMUSG00205032034
 protein coding gene Chr8:117725470-117755775 (+)
JF1/MsJ ENSUMUG00000017136
 protein coding gene Chr8:127161897-127191887 (+)
LP/J ENSMUSG00230028773
 protein coding gene Chr8:128480372-128510679 (+)
NOD/ShiLtJ ENSMUSG00190018494
 protein coding gene Chr8:118859706-118889763 (+)
NZO/HlLtJ ENSMUSG00225042580
 protein coding gene Chr8:131864577-131894658 (+)
PWK/PhJ ENSLUMG00010032343
 protein coding gene Chr8:118566543-118596510 (+)
SPRET/EiJ ENSMSPG00010037470
 protein coding gene Chr8:120755960-120786156 (+)
WSB/EiJ ENSIUOG00005027919
 protein coding gene Chr8:119544392-119574670 (+)



Homology
more
  • Human Ortholog
    TCF25, TCF25 ribosome quality control complex subunit
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TCF25, TCF25 ribosome quality control complex subunit
  • Synonyms
    FKSG26, hKIAA1049, Hulp1, NULP1, PRO2620
  • Links
    NCBI Gene ID: 22980
    UniProt: Q9BQ70

  • Chr Location
    16q24.3; chr16:89873566-89913627 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 3 alleles in 3 genetic backgrounds
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display increased responses of the heart to induced stress.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    798
  • Tissues
    81
  • cDNA Data
    413
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000001472 Ensembl Gene Model | MGI Sequence Detail 30083 C57BL/6J ±  kb
    transcript ENSMUST00000057934 Ensembl | MGI Sequence Detail 2738 Not Applicable  
    polypeptide ENSMUSP00000056485 Ensembl | MGI Sequence Detail 676 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 417
      Genomic 1
      cDNA 414
      Primer pair 1
      Other 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1196305, MGI:1919548
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 5
      Gene Ontology 8
      Phenotypes 6
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:371522 Ren W, et al., TCF25 serves as a nutrient sensor to orchestrate metabolic adaptation and cell death by enhancing lysosomal acidification under glucose starvation. Cell Rep. 2025 Aug 21;44(9):116186
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory