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Trim35 Gene Detail
Summary
  • Symbol
    Trim35
  • Name
    tripartite motif-containing 35
  • Synonyms
    0710005M05Rik, A430106H13Rik, Hls5, Mair, mKIAA1098
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914104
    NCBI Gene: 66854
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:66534480-66548873 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 34.44 cM, cytoband D1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    67 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914104
protein coding gene Chr14:66534474-66548873 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021494
protein coding gene Chr14:60969863-60984254 (+)
A/J MGP_AJ_G0021453
protein coding gene Chr14:59519284-59533677 (+)
AKR/J MGP_AKRJ_G0021429
protein coding gene Chr14:61592448-61606855 (+)
BALB/cJ MGP_BALBcJ_G0021459
protein coding gene Chr14:59489334-59503735 (+)
C3H/HeJ MGP_C3HHeJ_G0021236
protein coding gene Chr14:61275963-61290354 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021898
protein coding gene Chr14:63780255-63794648 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019438
protein coding gene Chr14:57454394-57469413 (+)
CAST/EiJ MGP_CASTEiJ_G0020753
protein coding gene Chr14:57751049-57765483 (+)
CBA/J MGP_CBAJ_G0021203
protein coding gene Chr14:65716514-65730906 (+)
DBA/2J MGP_DBA2J_G0021326
protein coding gene Chr14:59172941-59187326 (+)
FVB/NJ MGP_FVBNJ_G0021305
protein coding gene Chr14:58584221-58598610 (+)
LP/J MGP_LPJ_G0021401
protein coding gene Chr14:62016109-62030498 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021334
protein coding gene Chr14:64766041-64780442 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021921
protein coding gene Chr14:60790267-60804704 (+)
PWK/PhJ MGP_PWKPhJ_G0020497
protein coding gene Chr14:55907307-55921653 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020330
protein coding gene Chr14:56752423-56766769 (+)
WSB/EiJ MGP_WSBEiJ_G0020806
protein coding gene Chr14:61092652-61107050 (+)



Homology
more
  • Human Ortholog
    TRIM35, tripartite motif containing 35
  • Vertebrate Orthologs
    21
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TRIM35, tripartite motif containing 35
  • Synonyms
    HLS5, MAIR
  • Links
    NCBI Gene ID: 23087
    neXtProt AC: NX_Q9UPQ4
    UniProt: Q9UPQ4

  • Chr Location
    8p21.2; chr8:27284886-27311319 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased serum interferon-beta levels in response to vesicular stomatitis virus infection and show increased susceptibility to influenza A virus infection.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022043 Ensembl Gene Model | MGI Sequence Detail 14394 C57BL/6J ±  kb
    transcript ENSMUST00000022623 Ensembl | MGI Sequence Detail 3678 Not Applicable  
    polypeptide ENSMUSP00000022623 Ensembl | MGI Sequence Detail 516 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      cDNA 22

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1925036, MGI:2145786
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 7
      Gene Ontology 7
      Phenotypes 6
    • Earliest
      J:65653 Wertz K, et al., Large-scale screen for genes involved in gonad development. Mech Dev. 2000 Nov;98(1-2):51-70
    • Latest
      J:303214 Sun N, et al., TRIM35 mediates protection against influenza infection by activating TRAF3 and degrading viral PB2. Protein Cell. 2020 Dec;11(12):894-914

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    11/30/2021
    MGI 6.17
    The Jackson Laboratory