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Acot13
Gene Detail
Symbol

Name
ID
Acot13
acyl-CoA thioesterase 13
MGI:1914084
Synonyms
0610006O17Rik, Them2
Feature Type
protein coding gene
Genetic Map
Chromosome 13
10.69 cM, cytoband A3.2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr13:24817948-24831517 bp, - strand
From VEGA annotation of GRCm38

  13570 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:41273  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Gene Tree: Acot13

Human
homologs
Human Homolog ACOT13, acyl-CoA thioesterase 13
NCBI Gene ID 55856
neXtProt AC  NX_Q9NPJ3
Human Synonyms  PNAS-27, THEM2
Human Chr (Location)  6p22.3; chr6:24667035-24705069 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(5) Targeted(4)
 
Mice homozygous for a knock-out allele exhibit decreased body weight, reduced white adipose tissue and abnormal hepatic lipid and glucose metabolism, especially in mice fed a high fat diet.
 
Interactions
Acot13 interacts with 15 markers (Mir29b-1, Mir29b-2, Mir32, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (1 records)
Data Summary: Results (22)    Tissues (3)    Images (15)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 22
cDNA source data(76)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(77) Genomic(1) cDNA(76)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000000608 (Evidence)
Ensembl Gene ModelENSMUSG00000006717 (Evidence)
Entrez Gene66834 (Evidence)
UniGene2125
DFCITC1576814
DoTSDT.494319
NIA Mouse Gene IndexU034628
EC3.1.2.-
PDB2CY9
Consensus CDS ProjectCCDS26380.1
International Mouse Knockout Project StatusAcot13
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000608 VEGA Gene Model | MGI Sequence Detail 13570 C57BL/6J ±  kb
transcript OTTMUST00000001206 VEGA | MGI Sequence Detail 721 Not Applicable 
polypeptide OTTMUSP00000000564 VEGA | MGI Sequence Detail 140 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(2) UniProt(3)
Polymorphisms
SNPs within 2kb(197 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003736 Phenylacetic acid degradation-related domain
InterPro IPR006683 Thioesterase superfamily
Protein Ontology PR:000029260 acyl-coenzyme A thioesterase 13
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:204997 Kang HW, et al., Thioesterase superfamily member 2/Acyl-CoA thioesterase 13 (Them2/Acot13) regulates adaptive thermogenesis in mice. J Biol Chem. 2013 Nov 15;288(46):33376-86
All references(40)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory