Cab39l MGI Mouse Gene Detail - MGI:1914081 - calcium binding protein 39-like

Symbol

Cab39l
Name

calcium binding protein 39-like
Synonyms

1500031K13Rik, 2810425O13Rik, 4930520C08Rik, MO2L

Feature Type

protein coding gene
IDs

MGI:1914081
NCBI Gene: 69008
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr14:59678400-59786353 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 31.48 cM
Mapping Data

2 experiments

SNPs within 2kb

2510 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914081	protein coding gene	Chr14:59678400-59823213 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021425	protein coding gene	Chr14:53742057-53864503 (+)
A/J	MGP_AJ_G0021384	protein coding gene	Chr14:52614933-52724827 (+)
AKR/J	MGP_AKRJ_G0021359	protein coding gene	Chr14:54474929-54598357 (+)
BALB/cJ	MGP_BALBcJ_G0021389	protein coding gene	Chr14:52576391-52686733 (+)
C3H/HeJ	MGP_C3HHeJ_G0021167	protein coding gene	Chr14:54133478-54255524 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021828	protein coding gene	Chr14:56413408-56543067 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019368	protein coding gene	Chr14:50672456-50762563 (+)
CAST/EiJ	MGP_CASTEiJ_G0020683	protein coding gene	Chr14:50545754-50664663 (+)
CBA/J	MGP_CBAJ_G0021134	protein coding gene	Chr14:58006245-58136706 (+)
DBA/2J	MGP_DBA2J_G0021257	protein coding gene	Chr14:52285069-52396840 (+)
FVB/NJ	MGP_FVBNJ_G0021235	protein coding gene	Chr14:51699813-51807697 (+)
LP/J	MGP_LPJ_G0021331	protein coding gene	Chr14:54771564-54891118 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021264	protein coding gene	Chr14:57420726-57543734 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021851	protein coding gene	Chr14:53622618-53736158 (+)
PWK/PhJ	MGP_PWKPhJ_G0020427	protein coding gene	Chr14:48924055-49037418 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020260	protein coding gene	Chr14:49630859-49740933 (+)
WSB/EiJ	MGP_WSBEiJ_G0020736	protein coding gene	Chr14:53938833-54056558 (+)

Human Ortholog

CAB39L, calcium binding protein 39 like

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CAB39L, calcium binding protein 39 like
Synonyms

bA103J18.3, MLAA-34, MO25-BETA, MO2L
Links

HGNC:20290

NCBI Gene ID: 81617

UniProt: Q9H9S4
Chr Location

13q14.2; chr13:49308650-49444064 (-) GRCh38

MGI Vertebrate Homology

Cab39l stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CAB39L
Gene Tree

Cab39l

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Phenotype Summary

4 phenotypes from 2 alleles in 2 genetic backgrounds
20 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

23
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

13
Targeted

6
Genomic Mutations

1 involving Cab39l
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

31 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice show dysregulated basal-to-luminal urothelial differentiation, with expansion of the basal undifferentiated layer of the bladder urothelium, and show increased susceptibility to tobacco-related carcinogen BBN-induced basal bladder cancer.

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All GO Annotations

2
GO References

1

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

797
Tissues

60
cDNA Data

99
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cab39l

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All Sequences

66
RefSeq

14
UniProt

3
CCDS

CCDS27171.1

Ensembl

ENSMUSG00000021981 (Evidence)
NCBI Gene

69008

			Length	Strain/Species	Flank
genomic	69008	NCBI Gene Model \| MGI Sequence Detail	107954	C57BL/6J	± kb
transcript	NM_001360591	RefSeq \| MGI Sequence Detail	3113	C57BL/6
polypeptide	Q9DB16	UniProt \| EBI \| MGI Sequence Detail	337	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000004928 calcium-binding protein 39-like

(term hierarchy)
InterPro Domains

IPR011989 Armadillo-like helical

IPR016024 Armadillo-type fold

IPR013878 Mo25-like

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All nucleic 99

cDNA 99

Microarray probesets 6

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MGI:1916258, MGI:1922871, MGI:2145574

Summaries

All 44

Developmental Gene Expression 3

Gene Ontology 1

Phenotypes 20
Earliest

J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
Latest

J:358384 Ferdaus MZ, et al., Kinase Scaffold Cab39 Is Necessary for Phospho-Activation of the Thiazide-Sensitive NCC. Hypertension. 2024 Apr;81(4):801-810

TSS for Cab39l:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr125903	Chr14:59678021-59678031 (+)	-374 bp
Tssr125904	Chr14:59678396-59678445 (+)	21 bp
Tssr125905	Chr14:59716284-59716301 (+)	37,893 bp
Tssr125906	Chr14:59716313-59716372 (+)	37,943 bp
Tssr125907	Chr14:59716381-59716440 (+)	38,011 bp
Tssr125908	Chr14:59716463-59716481 (+)	38,072 bp
Tssr125909	Chr14:59728697-59728712 (+)	50,305 bp
Tssr125910	Chr14:59739335-59739352 (+)	60,944 bp
Tssr125911	Chr14:59764180-59764201 (+)	85,791 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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