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Duoxa2
Gene Detail
 Symbol
Name
ID
Duoxa2
dual oxidase maturation factor 2
MGI:1914061
Synonyms 9030623N16Rik
Feature Type protein coding gene
Genetic Map
Chromosome 2
60.62 cM, cytoband F1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:122298900-122302885 bp, + strand
From VEGA annotation of GRCm38

  3986 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:57037  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 chicken; 1 zebrafish

Gene Tree: Duoxa2

Human
homologs
Human Homolog DUOXA2, dual oxidase maturation factor 2
NCBI Gene ID 405753
neXtProt AC  NX_Q1HG44
Human Synonyms  SIMNIPHOM, TDH5
Human Chr (Location)  15q15.1; chr15:45114325-45118106 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human DUOXA2
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
 
Mice homozygous for a knock-out allele of Duoxa1 and 2 exhibit severe hypothyrodism with severe postnatal growth, delayed eye opening, enlarged thyroid, enlarged adenohypophysis, respiratory distress and death at weaning when weaned at 21 days.
 
Interactions
Duoxa2 interacts with 56 markers (Mir1b, Mir31, Mir101a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process hydrogen peroxide metabolic process, protein transport, ...
Component endoplasmic reticulum, endoplasmic reticulum membrane, ...
Function molecular_function
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(6)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(6) cDNA(6)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000015566 (Evidence)
Ensembl Gene ModelENSMUSG00000027225 (Evidence)
Entrez Gene66811 (Evidence)
UniGene171333
DFCITC1587007
DoTSDT.60104516
NIA Mouse Gene IndexU002373
Consensus CDS ProjectCCDS16660.1
International Mouse Knockout Project StatusDuoxa2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015566 VEGA Gene Model | MGI Sequence Detail 3986 C57BL/6J ±  kb
transcript OTTMUST00000036988 VEGA | MGI Sequence Detail 1592 Not Applicable 
polypeptide OTTMUSP00000016596 VEGA | MGI Sequence Detail 320 Not Applicable 

For the selected sequences
All sequences(17) RefSeq(2) UniProt(1)
Polymorphisms SNPs within 2kb(76 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018469 Dual oxidase maturation factor
Protein Ontology PR:000006730 dual oxidase maturation factor 2
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:205165 Chang S, et al., Dual oxidase regulates neutrophil recruitment in allergic airways. Free Radic Biol Med. 2013 Dec;65:38-46
All references(29)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory