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Tmtc2 Gene Detail
Summary
  • Symbol
    Tmtc2
  • Name
    transmembrane and tetratricopeptide repeat containing 2
  • Synonyms
    8430438D04Rik, D330034A10Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914057
    NCBI Gene: 278279
  • Gene Overview
    MyGene.info: TMTC2
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:105187663-105574451 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 54.72 cM, cytoband D1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4792 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914057
protein coding gene Chr10:105187663-105574479 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017702
protein coding gene Chr10:107268818-107676834 (-)
A/J MGP_AJ_G0017679
protein coding gene Chr10:103287756-103678680 (-)
AKR/J MGP_AKRJ_G0017641
protein coding gene Chr10:106292681-106707172 (-)
BALB/cJ MGP_BALBcJ_G0017643
protein coding gene Chr10:103668794-104071792 (-)
C3H/HeJ MGP_C3HHeJ_G0017468
protein coding gene Chr10:106327637-106741118 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018100
protein coding gene Chr10:111012544-111430173 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015779
protein coding gene Chr10:98336115-98717959 (-)
CAST/EiJ MGP_CASTEiJ_G0017029
protein coding gene Chr10:106428305-106862624 (-)
CBA/J MGP_CBAJ_G0017437
protein coding gene Chr10:115295523-115730580 (-)
DBA/2J MGP_DBA2J_G0017542
protein coding gene Chr10:102392394-102786145 (-)
FVB/NJ MGP_FVBNJ_G0017536
protein coding gene Chr10:101473395-101867522 (-)
LP/J MGP_LPJ_G0017616
protein coding gene Chr10:107889424-108305475 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017566
protein coding gene Chr10:117586784-118025342 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018138
protein coding gene Chr10:106252848-106668851 (-)
PWK/PhJ MGP_PWKPhJ_G0016811
protein coding gene Chr10:102466775-102862799 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016601
protein coding gene Chr10:104988105-105422572 (-)
WSB/EiJ MGP_WSBEiJ_G0017089
protein coding gene Chr10:106363466-106780330 (-)



Homology
more
  • Human Ortholog
    TMTC2, transmembrane and tetratricopeptide repeat containing 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TMTC2, transmembrane and tetratricopeptide repeat containing 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    IBDBP1
  • Links
    NCBI Gene ID: 160335
    neXtProt AC: NX_Q8N394
    UniProt: Q8N394

  • Chr Location
    12q21.31; chr12:82686952-83134868 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 25521
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: TMTC2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000036019 Ensembl Gene Model | MGI Sequence Detail 386789 C57BL/6J ±  kb
transcript ENSMUST00000061506 Ensembl | MGI Sequence Detail 5629 Not Applicable  
polypeptide ENSMUSP00000061919 Ensembl | MGI Sequence Detail 836 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 32
    cDNA 32

    Microarray probesets 4
Other
Accession IDs
less
MGI:2444719
References
more
  • Summaries
    All 32
    Developmental Gene Expression 1
    Gene Ontology 2
    Phenotypes 9
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory